Skip to main content

Table 6 Clinical endpoints and viral reactivation: adjusted analysis

From: Epstein–Barr virus, Cytomegalovirus, and Herpes Simplex-1/2 reactivations in critically ill patients with COVID-19

 

Any viral reactivation

CMV

EBV

HSV-1

In-hospital death

2.46 (1.02–5.89)

P = 0.045

Age: 1.04 (1.01–1.07), P = 0.042

SAPS: 1.34 (1.12–1.56), P = 0.034

AUC = 0.758 HL = 0.37

2.28 (0.96–5.44)

P = 0.062

Age: 1.05 (1.00–1.09), P = 0.053

SAPS: 1.39 (1.10–1.69), P = 0.032

1.16 (0.48–2.79)

P = 0.736

Age: 1.06 (0.92–1.20), P = 0.071

SAPS: 1.42 (0.82–2.08), P = 0.128

1.13 (0.49–2.60)

P = 0.736

Age: 1.05 (0.84–1.31), P = 0.375

SAPS: 1.50 (0.78–2.31), P = 0.481

ICU–BSI

2.37 (1.06–5.29)

P = 0.034

Age: 1.12 (1.05–1.20), P = 0.029

SAPS: 1.25 (1.14–1.35), P = 0.037

AUC = 0.646 HL = 0.37

2.38 (1.08–5.22)

P = 0.031

Age: 1.15 (1.08–1.23), P = 0.028

SAPS: 1.32 (1.10–1.55), P = 0.039

2.41(1.08–5.37)

P = 0.031

Age:1.07 (1.02–1.12), P = 0.047

SAPS: 1.44 (0.84–2.12), P = 0.124

1.10 (0.52–2.34)

P = 0.786

Age: 1.83 (0.95–2.78), P = 0.087

SAPS: 2.18 (0.52–3.83), P = 0.420

VAP

2.64 (1.20–5.82)

P = 0.016

Age: 1.42 (1.21–1.63), P = 0.027

SAPS: 1.74 (1.29–2.20), P = 0.019

AUC = 0.649 HL = 0.47

2.33 (1.08–5.02)

P = 0.030

Age:1.51 (1.24–1.78), P = 0.028

SAPS: 1.68 (1.29–2.01), P = 0.035

1.73 (0.79–3.74)

P = 0.164

Age: 1.37 (0.95–1.75), P = 0.058

SAPS: 1.89 (1.14–2.73), P = 0.039

1.59 (0.75–3.35)

P = 0.220

Age: 1.72 (0.75–2.57), P = 0.671

SAPS: 2.58 (0.85–4.18), P = 0.394

  1. Data are shown as odds ratio (95% confidence interval). Data are adjusted for age and SAPS score
  2. AUC Area Under the ROC Curve. HL P value associated with Hosmer–Lemeshow test. ICU–BSI (Intensive Care Unit Bloodstream Infections), VAP (Ventilator-Associated Pneumonia)