Table 1 Animal study characteristics

Cardiac output (L/min)

5.4 (5.2–5.6)

6.0 (5.6–6.3)

2.2 (1.8–2.4)

2.5 (2.3–3.3)

Heart rate (beats per minute)

75 (66–82)

83 (78–84)

70 (66–72)

78 (75–80)

60 (58–64)

70 (67–86)

57 (53–58)

64 (59–68)

53 (47–58)

65 (63–80)

50 (43–58)

63 (61–72)

Mean arterial pressure (mmHg)

72 (64–88)

73 (62–79)

36 (33–44)

43 (36–48)

71 (66–77)

57 (45–62)

82 (72–88)

65 (64–74)

84 (72–91)

69 (57–82)

72 (60–83)

63 (56–72)

Pulse pressure (mmHg)

47 (32–53)

39 (32–40)

9 (8–10)

10 (10–14)

6 (6–6)

10 (6–12)

6 (4–10)

8 (8–8)

6 (6–10)

9 (8–12)

6 (5–6)

11 (9–12)

Cardiac power output (W)

0.9 (0.7–1.0)

1.0 (0.8–1.1)

0.1 (0.1–0.2)

0.3 (0.2–0.3)

Mean pulmonary artery pressure (mmHg)

26 (26–30)

23 (20–26)

31 (26–32)

26 (23–28)

26 (18–30)

24 (18–29)

27 (17–28)

24 (21–29)

28 (20–30)

27 (24–33)

31 (23–33)

27 (22–32)

Pulmonary artery diastolic pressure (mmHg)

24 (21–27)

16 (15–19)

28 (22–30)

21 (20–22)

23 (23–28)

22 (18–26)

23 (16–23)

22 (19–25)

25 (23–28)

26 (20–30)

28 (21–28)

19 (18–30)

Left ventricle end-diastolic pressure (mmHg)

18 (17–19)

21 (20–22)

22 (21–22)

24 (20–26)

14 (11–15)

24 (20–27)

15 (13–18)

27 (24–29)

12 (11–14)

24 (23–28)

11 (10–15)

22 (18–28)

Mixed venous saturation (%)

62 (51–65)

65 (54–66)

28 (22–30)

36 (32–41)

67 (64–75)

60 (41–69)

71 (65–80)

59 (56–70)

75 (68–83)

58 (47–72)

72 (66–80)

75 (55–81)

Carotid artery flow (ml/min)

248 (226–261)

278 (249–301)

57 (24–86)

122 (98–144)

154 (116–271)

174 (162–211)

123 (116–268)

186 (174–222)

171 (141–248)

224 (176–248)

250 (134–316)

248 (208–297)

Renal venous pressure (mmHg)

6 (6–9)

10 (10–11)

7 (6–10)

13 (10–16)

6 (5–7)

8 (7–10)

6 (5–6)

11 (8–12)

7 (6–8)

10 (8–12)

7 (6–7)

11 (8–12)

Renal venous saturation (%)

82 (69–85)

75 (71–76)

39 (26–51)

30 (30–59)

87 (83–91)

77 (61–93)

87 (73–88)

57 (50–97)

86 (86–91)

84 (51–96)

74 (56–83)

71 (62–96)

Urine output (ml/h)

–

–

–

–

285 (185–475)

160 (85–270)

110 (57–330)

60 (49–72)

65 (40–272)

82 (62–102)

105 (42–273)

50 (16–144)

Norepinephrine (µg/kg/min)

0 (0–0)

0 (0–0)

0 (0–0.02)

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0.07)

0 (0–0)

0 (0–0.04)

V-A ECMO flow (L/min)

–

–

3.4 (3.4–3.4)

3.3 (3.2–3.4)

3.3 (3.1–3.4)

3.4 (3.4–3.7)

3.3 (3.0–3.5)

3.5 (3.4–3.8)

3.3 (3.1–3.6)

3.6 (3.4–4.0)

3.5 (3.0–3.7)

3.5 (3.4–4.1)

Impella flow (L/min)

–

–

–

–

1.0 (0.9–2.0)

–

1.8 (1.0–2.3)

–

1.9 (1.4–2.3)

–

1.7 (1.3–2.4)

–

Blood lacate (mmol/L)

1.3 (0.8–2.3)

0.9 (0.9–1.1)

2.5 (2.2–2.9)

2.1 (1.0–2.6)

3.4 (3.0–3.6)

2.7 (2.6–4.4)

3.7 (3.4–4.3)

3.5 (2.7–4.4)

3.4 (3.2–4.1)

4.6 (3.5–5.9)

3.5 (2.8–4.0)

4.4 (3.6–5.4)