Articles
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Citation: Intensive Care Medicine Experimental 2022 10:48
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Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells
Mitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional to the doses of noradrenaline, which patients are receiving. We compreh...
Citation: Intensive Care Medicine Experimental 2022 10:47 -
Pathophysiology of fluid administration in critically ill patients
Fluid administration is a cornerstone of treatment of critically ill patients. The aim of this review is to reappraise the pathophysiology of fluid therapy, considering the mechanisms related to the interplay ...
Citation: Intensive Care Medicine Experimental 2022 10:46 -
Dysregulated expression of amino-acid and glucose transporters on circulating plasma cells in septic shock patients: a preliminary study
Citation: Intensive Care Medicine Experimental 2022 10:44 -
Circular RNAs to predict clinical outcome after cardiac arrest
Cardiac arrest (CA) represents the third leading cause of death worldwide. Among patients resuscitated and admitted to hospital, death and severe neurological sequelae are frequent but difficult to predict. Bl...
Citation: Intensive Care Medicine Experimental 2022 10:41 -
Cerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care
Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled ca...
Citation: Intensive Care Medicine Experimental 2022 10:45 -
T cell dysregulation in inflammatory diseases in ICU
Severe inflammatory diseases, including sepsis, are characterized by an impaired host adaptive and innate immunity which results in immunosuppression, responsible for secondary infections and increased morbidi...
Citation: Intensive Care Medicine Experimental 2022 10:43 -
ESICM LIVES 2022: part 2
Citation: Intensive Care Medicine Experimental 2022 10(Suppl 2):40 -
ESICM LIVES 2022: part 1
Citation: Intensive Care Medicine Experimental 2022 10(Suppl 2):39 -
Development and validation of an early warning model for hospitalized COVID-19 patients: a multi-center retrospective cohort study
Timely identification of deteriorating COVID-19 patients is needed to guide changes in clinical management and admission to intensive care units (ICUs). There is significant concern that widely used Early warn...
Citation: Intensive Care Medicine Experimental 2022 10:38 -
Hemodynamic management of acute brain injury caused by cerebrovascular diseases: a survey of the European Society of Intensive Care Medicine
The optimal hemodynamic targets and management of patients with acute brain injury are not completely elucidated, but recent evidence points to important impact on clinical outcomes. We performed an internatio...
Citation: Intensive Care Medicine Experimental 2022 10:42 -
Comparison of two porcine acute lung injury models: a post-hoc analysis
Acute respiratory distress syndrome (ARDS) is a common disease in intensive care medicine. Despite intensive research, mortality rates are high, not even in COVID-19 ARDS. Thereby, pigs offer some advantages t...
Citation: Intensive Care Medicine Experimental 2022 10:37 -
Plasma volume expansion reveals hidden metabolic acidosis in patients with diabetic ketoacidosis
Hyperchloremic metabolic acidosis that develops during the treatment of diabetic ketoacidosis is usually attributed to the chloride content of resuscitation fluids. We explored an alternative explanation, name...
Citation: Intensive Care Medicine Experimental 2022 10:36 -
Physiologic responses to exercise in survivors of critical illness: an exploratory pilot study
ICU survivors suffer from impaired physical function and reduced exercise capacity, yet the underlying mechanisms are poorly understood. The goal of this exploratory pilot study was to investigate potential me...
Citation: Intensive Care Medicine Experimental 2022 10:35 -
Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury
Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range of conditions including sepsis. Fresh frozen plasma (FFP) restores the damaged EG to baseline thickness, however the mech...
Citation: Intensive Care Medicine Experimental 2022 10:34 -
Optimal bispectral index level of sedation and cerebral oximetry in traumatic brain injury: a non-invasive individualized approach in critical care?
Impaired cerebral autoregulation has been linked with worse outcomes, with literature suggesting that current therapy guidelines fail to significantly impact cerebrovascular reactivity. The cerebral oximetry i...
Citation: Intensive Care Medicine Experimental 2022 10:33 -
Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury
Models of hypoxemic lung injury caused by lavage-induced pulmonary surfactant depletion are prone to prompt recovery of blood oxygenation following recruitment maneuvers and have limited translational validity...
Citation: Intensive Care Medicine Experimental 2022 10:32 -
Fast versus slow infusion of 20% albumin: a randomized controlled cross-over trial in volunteers
We investigated whether plasma volume (PV) expansion of 20% albumin is larger when the fluid is administered rapidly compared with a slow infusion.
Citation: Intensive Care Medicine Experimental 2022 10:31 -
Closed-loop automated critical care as proof-of-concept study for resuscitation in a swine model of ischemia–reperfusion injury
Volume expansion and vasopressors for the treatment of shock is an intensive process that requires frequent assessments and adjustments. Strict blood pressure goals in multiple physiologic states of shock (tra...
Citation: Intensive Care Medicine Experimental 2022 10:30 -
Mouse sepsis models: don't forget ambient temperature!
Citation: Intensive Care Medicine Experimental 2022 10:29 -
Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases
Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the physiology of organ viability and in the pathophysiology of organ dysfunction, respectively. In this narrative review, we...
Citation: Intensive Care Medicine Experimental 2022 10:28 -
Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis
Sex differences in sepsis are underexplored and incompletely understood. Cardiac function in early sepsis is pivotal in determining survival; hyperdynamic left ventricular ejection fraction is associated with ...
Citation: Intensive Care Medicine Experimental 2022 10:27 -
Machine learning approaches to the human metabolome in sepsis identify metabolic links with survival
Metabolic predictors and potential mediators of survival in sepsis have been incompletely characterized. We examined whether machine learning (ML) tools applied to the human plasma metabolome could consistentl...
Citation: Intensive Care Medicine Experimental 2022 10:24 -
Extracorporeal immune cell therapy of sepsis: ex vivo results
Immune cell dysfunction plays a central role in sepsis-associated immune paralysis. The transfusion of healthy donor immune cells, i.e., granulocyte concentrates (GC) potentially induces tissue damage via loca...
Citation: Intensive Care Medicine Experimental 2022 10:26 -
The frailty, outcomes, recovery and care steps of critically ill patients (FORECAST) study: pilot study results
Frailty is common in critically ill patients and is associated with increased morbidity and mortality. There remains uncertainty as to the optimal method/timing of frailty assessment and the impact of care pro...
Citation: Intensive Care Medicine Experimental 2022 10:23 -
Respiratory system mechanics in one-lung ventilation using double-lumen tubes
Citation: Intensive Care Medicine Experimental 2022 10:25 -
Intracycle power distribution in a heterogeneous multi-compartmental mathematical model: possible links to strain and VILI
Repeated expenditure of energy and its generation of damaging strain are required to injure the lung by ventilation (VILI). Mathematical modeling of passively inflated, single-compartment lungs with uniform pa...
Citation: Intensive Care Medicine Experimental 2022 10:21 -
Simple, accurate calculation of mechanical power in pressure controlled ventilation (PCV)
Mechanical power is a promising new metric to assess energy transfer from a mechanical ventilator to a patient, which combines the contributions of multiple parameters into a single comprehensive value. Howeve...
Citation: Intensive Care Medicine Experimental 2022 10:22 -
Hydrocephalus and the neuro-intensivist: CSF hydrodynamics at the bedside
Hydrocephalus (HCP) is far more complicated than a simple disorder of cerebrospinal fluid (CSF) circulation. HCP is a common complication in patients with subarachnoid hemorrhage (SAH) and after craniectomy. C...
Citation: Intensive Care Medicine Experimental 2022 10:20 -
Flow-controlled ventilation in moderate acute respiratory distress syndrome due to COVID-19: an open-label repeated-measures controlled trial
Flow-controlled ventilation (FCV), a novel mode of mechanical ventilation characterised by constant flow during active expiration, may result in more efficient alveolar gas exchange, better lung recruitment an...
Citation: Intensive Care Medicine Experimental 2022 10:19 -
Response to the Correspondence of Helbing et al. “Mouse sepsis models: don't forget ambient temperature!”
Citation: Intensive Care Medicine Experimental 2022 10:18 -
Duodenum edema due to reduced lymphatic drainage leads to increased inflammation in a porcine endotoxemic model
Interventions, such as mechanical ventilation with high positive end-expiratory pressure (PEEP), increase inflammation in abdominal organs. This effect could be due to reduced venous return and impaired splanc...
Citation: Intensive Care Medicine Experimental 2022 10:17 -
Ventilator dysfunction due to unexpected salbutamol crystallisation while using a nebuliser: a practical advice for intensivists
Citation: Intensive Care Medicine Experimental 2022 10:16 -
Lung perfusion during veno-venous extracorporeal membrane oxygenation in a model of hypoxemic respiratory failure
Veno-venous extracorporeal membrane oxygenation (ECMO) provides blood oxygenation and carbon dioxide removal in acute respiratory distress syndrome. However, during ECMO support, the native lungs still play an...
Citation: Intensive Care Medicine Experimental 2022 10:15 -
Evaluation of an extracorporeal ozone-based bactericide system for the treatment of Escherichia coli sepsis
Sepsis is associated with substantial mortality rates. Antibiotic treatment is crucial, but global antibiotic resistance is now classified as one of the top ten global public health risks facing humanity. Ozon...
Citation: Intensive Care Medicine Experimental 2022 10:14 -
Determinants of venous return in steady-state physiology and asphyxia-induced circulatory shock and arrest: an experimental study
Mean circulatory filling pressure (Pmcf) provides information on stressed volume and is crucial for maintaining venous return. This study investigated the Pmcf and other determinants of venous return in dysrhy...
Citation: Intensive Care Medicine Experimental 2022 10:13 -
Recovery of organ-specific tissue oxygen delivery at restrictive transfusion thresholds after fluid treatment in ovine haemorrhagic shock
Fluid resuscitation is the standard treatment to restore circulating blood volume and pressure after massive haemorrhage and shock. Packed red blood cells (PRBC) are transfused to restore haemoglobin levels. R...
Citation: Intensive Care Medicine Experimental 2022 10:12 -
Analysis of acid–base disorders in an ICU cohort using a computer script
Acid–base status is important for understanding pathophysiology, making a diagnosis, planning effective treatment and monitoring progress of critically ill patients. Manual calculations are cumbersome, easily ...
Citation: Intensive Care Medicine Experimental 2022 10:11 -
Mathematical modelling of oxygenation under veno-venous ECMO configuration using either a femoral or a bicaval drainage
The bicaval drainage under veno-venous extracorporeal membrane oxygenation (VV ECMO) was compared in present experimental study to the inferior caval drainage in terms of systemic oxygenation.
Citation: Intensive Care Medicine Experimental 2022 10:10 -
Should we continue searching for the single best PEEP?
Citation: Intensive Care Medicine Experimental 2022 10:9 -
Towards a biological definition of ARDS: are treatable traits the solution?
The pathophysiology of acute respiratory distress syndrome (ARDS) includes the accumulation of protein-rich pulmonary edema in the air spaces and interstitial areas of the lung, variable degrees of epithelial ...
Citation: Intensive Care Medicine Experimental 2022 10:8 -
Comparison between two solute equations and bioimpedance for estimation of body fluid volumes
The extracellular volume (ECV) and intracellular volume (ICV) estimated by bioimpedance analysis (BIA) deviates markedly from the textbook volumes of 20% and 40% of the body weight (BW). We estimated the trans...
Citation: Intensive Care Medicine Experimental 2022 10:7 -
Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation
Interleukin-1 receptor antagonists can reduce mortality in septic shock patients with hepatobiliary dysfunction and disseminated intravascular coagulation (HBD + DIC), an organ failure pattern with inflammator...
Citation: Intensive Care Medicine Experimental 2022 10:6 -
High levels of monocytic myeloid-derived suppressor cells are associated with favorable outcome in patients with pneumonia and sepsis with multi-organ failure
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunosuppressive functions sub-classified into monocytic and polymorphonuclear MDSCs (M-MDSCs and PMN-MDSCs). Clinical studies reported...
Citation: Intensive Care Medicine Experimental 2022 10:5 -
Effects of norepinephrine infusion on cerebral energy metabolism during experimental haemorrhagic shock
The use of norepinephrine in the case of life-threatening haemorrhagic shock is well established but widely discussed. The present study was designed to compare the effects of early norepinephrine treatment vs...
Citation: Intensive Care Medicine Experimental 2022 10:4 -
Influence of noise manipulation on retention in a simulated ICU ward round: an experimental pilot study
Noise exposure leads to a reduction in cognitive abilities in diverse settings, however, only limited data exist examining the effects of environmental ICU noise on the cognitive performance of ICU professiona...
Citation: Intensive Care Medicine Experimental 2022 10:3 -
Structural equation modelling the relationship between anti-fungal prophylaxis and Pseudomonas bacteremia in ICU patients
Animal models implicate candida colonization facilitating invasive bacterial infections. The clinical relevance of this microbial interaction remains undefined and difficult to study directly. Observations fro...
Citation: Intensive Care Medicine Experimental 2022 10:2 -
The effect of shock duration on trauma-induced coagulopathy in a murine model
Trauma-induced coagulopathy (TIC) is a life-threatening condition associated with high morbidity and mortality. TIC can present with different coagulation defects. In this study, the aim was to determine the e...
Citation: Intensive Care Medicine Experimental 2022 10:1 -
Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges
Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. Wh...
Citation: Intensive Care Medicine Experimental 2021 9:61 -
Towards an ecological definition of sepsis: a viewpoint
In critically ill patients with sepsis, there is a grave lack of effective treatment options to address the illness-defining inappropriate host response. Currently, treatment is limited to source control and s...
Citation: Intensive Care Medicine Experimental 2021 9:63
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- ISSN: 2197-425X (electronic)