Volume 2 Supplement 1
0101. Early and severe impairment of lactate clearance in endotoxic shock is not related to liver hypoperfusion: preliminary report
© Tapia et al; licensee Springer. 2014
Published: 26 September 2014
Although the prognostic value of persistent hyperlactatemia in septic shock is unequivocal, its physiological determinants are controversial. In particular, the role of impaired hepatic clearance has been considered as relevant only in severe shock with liver ischemia or advanced cirrhosis. However, very few studies have addressed this subject.
To determine the evolution of lactate clearance  in an endotoxic sheep model.
Hyperdynamic endotoxic shock induces an early, severe and persistent impaired lactate clearance that is not related to liver hypoerfusion, O2 extraction or mitochondrial function.
FONDECYT 1130200, Chile.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.