Table 2 Lung mechanics, hemodynamics, gas exchange, acid-base status, and metabolic parameters
Vehicle | HAM1101 | p value | ||
|---|---|---|---|---|
Hemoglobin content (mg·mL−1) | Start | 90 (87, 96) | 98 (95, 105) | 0.074 |
End | 70 (66, 72) | 69 (66, 74) | 0.806 | |
Heart rate (beats·min−1) | Start | 494 (485, 515) | 430 (406, 480) | 0.248 |
End | 426 (406, 445) | 391 (349,430) | 0.290 | |
Mean arterial pressure (mmHg) | Start | 69 (65, 71) | 69 (66, 76) | 0.382 |
End | 64 (59, 69) | 67 (66, 72) | 0.441 | |
Thoracopulmonary compliance (μL·cm H2O−1) | Start | 0.10 (0.09, 0.10) | 0.10 (0.09, 0.11) | 0.382 |
End | 0.09 (0.08, 0.10) | 0.10 (0.08, 0.11) | 0.427 | |
Arterial PO2 (mmHg) | Start | 314 (293, 330) | 340 (321, 350) | 0.254 |
End | 309 (287, 326) | 301 (287, 319) | 0.838 | |
Arterial PCO2 (mmHg) | Start | 31 (27, 33) | 31 (29, 36) | 0.879 |
End | 34 (33, 36) | 31 (28, 33) | 0.072 | |
Arterial pH | Start | 7.33 (7.30, 7.35) | 7.36 (7.32, 7.38) | 0.569 |
End | 7.38 (7.31, 7.43) | 7.43 (7.39, 7.46) | 0.253 | |
Arterial base excess (mmol·mL−1) | Start | −9.0 (−10.3, −7.7) | −6.8 (−8.3, −6.2) | 0.403 |
End | −5.7 (−7.1, −1.7) | −3.9 (−4.2, −3.3) | 0.838 | |
Arterial lactate (mmol·mL−1) | Start | n.d. | n.d. | n.d. |
End | 2.0 (1.7, 2.2) | 1.6 (1.5, 1.8) | 0.025 | |
Arterial glucose (mg·dL−1) | Start | 113 (110, 117) | 115 (106, 123) | 0.540 |
End | 110 (96, 117) | 111 (109, 115) | 0.653 | |
CO2 production rate (μL·g−1·min−1) | Start | 26 (24, 28) | 24 (23, 25) | 0.082 |
End | 23 (21, 26) | 23 (22, 25) | 0.596 | |
Glucose production rate (mg·g−1·h−1) | Start | 0.37 (0.35, 0.41) | 0.34 (0.31, 0.36) | 0.178 |
End | 0.38 (0.35, 0.39) | 0.33 (0.31, 0.39) | 0.153 | |
Glucose oxidation rate (% isotope infusion) | Start | 58 (55, 62) | 55 (50, 59) | 0.224 |
End | 57 (54, 60) | 62 (58, 67) | 0.047 | |