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Journal Impact Factor 2023: 2.8

An official journal of the European Society of Intensive Care Medicine (ESICM)

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New collection: Artificial Intelligence for Acute Respiratory Failure

New Content Item (1) © © Angelov /

This thematic collection aims to curate a groundbreaking compendium of research that harnesses the power of AI to revolutionize the management and treatment of acute respiratory failure. This collection will not only showcase the cutting-edge advancements in AI applications but also highlight the unique value proposition that these technologies bring to the field of critical care medicine.

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Collection: Tissue oxygenation: how to measure, how much to target

Hemodynamic management ultimately aims to restore oxygen availability in the tissue. Some hemodynamic variables, both on a macrohemodynamic and a microcirculatory scale, remain difficult to obtain in a clinical setting, and in many instances, more research is needed to determine their relevance in a physiologic context and evaluate individualized targets. This thematic collection aims at bringing together translational and basic original research and reviews on the subject.

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Collection : Blood purification in sepsis: from bench to bedside

The idea of extracorporeal blood purification (aside from classical renal replacement therapy) to eliminate injurious mediators of the sepsis syndrome has received increasing interest over the last years. In fact, blood purification techniques, such as hemoadsorption, are already widely used in clinical practice due to its plausible theoretical rationale, despite lack of clear evidence. Moreover, some recent studies have raised important risk-benefit concerns underlining the fundamental need of further research in this field. This thematic collection invites authors to focus on both pre-clinical and clinical approaches to explore future perspectives of blood purification in the additive treatment of sepsis. The aim is not only to contribute to an improved understanding of the molecular mechanisms influenced by blood purification but also to set the stage for taking the next steps to improve the clinical management.

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ICMx Reviews


Capillary leak and endothelial permeability in critically ill patients: a current overview

Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury

Pathophysiological implications of ventriculoarterial coupling in septic shock

Impact of critical illness on cholesterol and fatty acids: insights into pathophysiology and therapeutic targets

Understanding the mechanisms of ventilator-induced lung injury using animal models

Current knowledge gaps in extracorporeal respiratory support

Extracorporeal cardiopulmonary resuscitation in 2023

Distinct host-response signatures in circulatory shock: a narrative review

Fluid management strategies and their interaction with mechanical ventilation: from experimental studies to clinical practice

Research priorities for therapeutic plasma exchange in critically ill patients

Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis

Bioengineered extracellular vesicles: future of precision medicine for sepsis

Physiological adaptations during weaning from veno-venous extracorporeal membrane oxygenation

Electroencephalographic monitoring of brain activity during cardiac arrest: a narrative review


Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review

Pathophysiology of fluid administration in critically ill patients

T cell dysregulation in inflammatory diseases in ICU

Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases

Hydrocephalus and the neuro-intensivist: CSF hydrodynamics at the bedside

Towards a biological definition of ARDS: are treatable traits the solution?


Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges

Towards an ecological definition of sepsis: a viewpoint

Molecular mechanisms of postintensive care syndrome

The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis

Sepsis: deriving biological meaning and clinical applications from high-dimensional data

The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients


Ischaemic stroke-induced distal organ damage: pathophysiology and new therapeutic strategies

Fluids in ARDS: more pros than cons

Effects of higher PEEP and recruitment manoeuvres on mortality in patients with ARDS: a systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials

Extracellular vesicles as regulators of kidney function and disease

Pathophysiology and clinical consequences of arterial blood gases and pH after cardiac arrest

Role of the adaptive immune response in sepsis

Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation

H2S in acute lung injury: a therapeutic dead end (?)

Metabolic substrate utilization in stress-induced immune cells

Neuromuscular blocking agents in acute respiratory distress syndrome: updated systematic review and meta-analysis of randomized trials

Heart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models

Update of the organoprotective properties of xenon and argon: from bench to beside

Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness

Carbon monoxide in intensive care medicine—time to start the therapeutic application?!

Highly accessed papers 2023

Furosemide exacerbated the impairment of renal function, oxygenation and medullary damage in a rat model of renal ischemia/reperfusion induced AKI
Olcay Dilken, Can Ince, Aysegul Kapucu, Paul M. Heeman & Bülent Ergin
Research article  1 May 2023

Fluid management strategies and their interaction with mechanical ventilation: from experimental studies to clinical practice
Eduardo Butturini de Carvalho, Denise Battaglini, Chiara Robba, Manu L.N.G. Malbrain, Paolo Pelosi, Patricia Rieken Macedo Rocco & Pedro Leme Silva
Review  21 July 2023

Ventilation during continuous compressions or at 30:2 compression-to-ventilation ratio results in similar arterial oxygen and carbon dioxide levels in an experimental model of prolonged cardiac arrest
Jukka Kopra, Erik Litonius, Pirkka T. Pekkarinen, Merja Laitinen, Juho A. Heinonen, Luca Fontanelli, Tomi P. Mäkiaho & Markus B. Skrifvars 
Research article  6 January 2023

Pathophysiological implications of ventriculoarterial coupling in septic shock
Michael R. Pinsky & Fabio Guarracino 
Review  7 December 2023

Abstract  24 October 2023

Skip to Volume
  1. Volume 11

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    1. ESICM LIVES 2023

      Volume 11 Supplement 1

  2. Volume 10

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    1. ESICM LIVES 2022

      Volume 10 Supplement 2

    2. ESICM LIVES 2021 - Part 2

      Volume 10 Supplement 1

  3. Volume 9

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    1. ESICM LIVES 2021

      Volume 9 Supplement 1

  4. Volume 8

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    1. ESICM LIVES 2020

      Volume 8 Supplement 2

    2. The Fourth International Symposium on Acute Pulmonary Injury and Translation Research (INSPIRES IV)

      Volume 8 Supplement 1

  5. Volume 7

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    1. ESICM LIVES 2019

      Volume 7 Supplement 3

    2. Sepsis 2019

      Volume 7 Supplement 2

    3. Proceedings from the Third International Symposium on Acute Pulmonary Injury and Translational Research (INSPIRES III)

      Volume 7 Supplement 1

  6. Volume 6

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    1. ESICM LIVES 2018

      Volume 6 Supplement 2

    2. Sepsis 2018

      Volume 6 Supplement 1

  7. Volume 5

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    1. ESICM LIVES 2017

      Volume 5 Supplement 2

    2. Sepsis 2017 Paris

      Volume 5 Supplement 1

  8. Volume 4

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    1. ESICM LIVES 2016

      Volume 4 Supplement 1

  9. Volume 3

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    1. ESICM LIVES 2015

      Volume 3 Supplement 1

  10. Volume 2

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    1. ESICM LIVES 2014

      Volume 2 Supplement 1

ESICM meeting abstracts


Article-processing charges

Intensive Care Medicine Experimental levies an article-processing charge of £1690/$2490/€1990 for each article accepted for publication. For information on waivers and discounts, please visit our article-processing charge page.

Intensive Care Medicine


Aims and scope

Intensive Care Medicine Experimental (ICMx) is an open access journal specifically dedicated to translational research, aimed at bringing discoveries, potential novel treatments and improved diagnostics closer to the bedside of a critically ill patient. As such, ICMx is uniquely positioned at the intersection of clinical and basic science with a primary focus on the physiology of critical care and emergency medicine. ICMx is intended for all those involved in research aimed at improving emergency care of the critically ill.
ICMx aims at publishing research aspiring to: 1) advance understanding of critical illness pathophysiology, 2) support or enhance clinical trial design, 3) test experimental novel treatment interventions, 4) develop or refine experimental models that are relevant to critical care and acute physiologic derangements.

ICMx welcomes original studies, reviews, hypothesis papers and state-of-the-art methodology papers. We also encourage correspondence pertinent to the works published in ICMx. Editorial comments will be solicited.
  • ICMx is the official journal of the European Society of Intensive Care Medicine that is dedicated to translational research
  • ICMx is one of few journals publishing research constructing the pipeline of novel discoveries that can advance critical care
  • The board of ICMx represents physiologists, basic scientists dedicated to ICU medicine and ICU physicians, providing for an ideal platform to bring discoveries to clinical applications in critical care

Nicole Juffermans, Editor-in-Chief

University of Rotterdam, The Netherlands

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Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 2.8
    5-year Journal Impact Factor: 3.4
    Source Normalized Impact per Paper (SNIP): 0.868
    SCImago Journal Rank (SJR): 0.976

    Speed 2023
    Submission to first editorial decision (median days): 7
    Submission to acceptance (median days): 91

    Usage 2023
    Downloads: 703,771
    Altmetric mentions: 1,778