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Volume 8 Supplement 1

The Fourth International Symposium on Acute Pulmonary Injury and Translation Research (INSPIRES IV)

Research

Dresden, Germany25-26 November 2019

Publication of this supplement is funded by AMC Medical Research B.V. and University of Ulm. Peer review was organised by the conference committee. The Supplement Editors declare no competing interests.

Edited by Marcus Schultz, Marcelo Gama de Abreu and Peter Radermacher

Conference website

  1. In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction o...

    Authors: Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings and Nicole P. Juffermans

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):42

    Content type: Research

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  2. Alkaline phosphatase (AP), a dephosphorylating enzyme, is involved in various physiological processes and has been shown to have anti-inflammatory effects.

    Authors: Jenny Juschten, Sarah A. Ingelse, Lieuwe D. J. Bos, Armand R. J. Girbes, Nicole P. Juffermans, Tom van der Poll, Marcus J. Schultz and Pieter Roel Tuinman

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):46

    Content type: Research

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  3. Patients with liver diseases are at high risk for the development of acute respiratory distress syndrome (ARDS). The liver is an important organ that regulates a complex network of mediators and modulates orga...

    Authors: Raquel Herrero, Gema Sánchez, Iris Asensio, Eva López, Antonio Ferruelo, Javier Vaquero, Laura Moreno, Alba de Lorenzo, Rafael Bañares and José A. Lorente

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):48

    Content type: Research

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  4. The animal experimental counterpart of human acute respiratory distress syndrome (ARDS) is acute lung injury (ALI). Most models of ALI involve reproducing the clinical risk factors associated with human ARDS, ...

    Authors: Laura Chimenti, Luis Morales-Quinteros, Ferranda Puig, Marta Camprubi-Rimblas, Raquel Guillamat-Prats, Maria Nieves Gómez, Jessica Tijero, Lluis Blanch, Gustavo Matute-Bello and Antonio Artigas

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):62

    Content type: Research

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  5. Continuous external negative pressure (CENP) during positive pressure ventilation can recruit dependent lung regions. We hypothesised that CENP applied regionally to the thorax or the abdomen only, increases t...

    Authors: Martin Scharffenberg, Jakob Wittenstein, Moritz Herzog, Sebastian Tauer, Luigi Vivona, Raphael Theilen, Thomas Bluth, Thomas Kiss, Thea Koch, Giuseppe Fiorentino, Marcelo Gama de Abreu and Robert Huhle

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):49

    Content type: Research

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  6. Flow-controlled ventilation (FCV) allows expiratory flow control, reducing the collapse of the airways during expiration. The performance of FCV during one-lung ventilation (OLV) under intravascular normo- and...

    Authors: Jakob Wittenstein, Martin Scharffenberg, Xi Ran, Diana Keller, Pia Michler, Sebastian Tauer, Raphael Theilen, Thomas Kiss, Thomas Bluth, Thea Koch, Marcelo Gama de Abreu and Robert Huhle

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):24

    Content type: Research

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  7. Outcome prediction in patients with acute respiratory distress syndrome (ARDS) greatly improves when patients are reclassified based on predefined arterial oxygen partial pressure to fractional inspired oxygen...

    Authors: Fabienne D. Simonis, Laura R. A. Schouten, Olaf L. Cremer, David S. Y. Ong, Gabriele Amoruso, Gilda Cinella, Marcus J. Schultz and Lieuwe D. Bos

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):43

    Content type: Research

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  8. Outcome prediction in critically ill patients under invasive ventilation remains extremely challenging. The driving pressure (ΔP) and the mechanical power of ventilation (MP) are associated with patient-center...

    Authors: David M. P. van Meenen, Ary Serpa Neto, Frederique Paulus, Coen Merkies, Laura R. Schouten, Lieuwe D. Bos, Janneke Horn, Nicole P. Juffermans, Olaf L. Cremer, Tom van der Poll and Marcus J. Schultz

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):60

    Content type: Research

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  9. Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures. The complement system has been suggested to play a causative...

    Authors: Friso M. de Beer, Luuk Wieske, Gerard van Mierlo, Diana Wouters, Sacha Zeerleder, Lieuwe D. Bos, Nicole P. Juffermans, Marcus J. Schultz, Tom van der Poll, Wim K. Lagrand and Janneke Horn

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):74

    Content type: Research

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  10. Accumulated airway secretions in the endotracheal tube increase work of breathing and may favor airway colonization eventually leading to pneumonia. The aim of this preplanned substudy of the ‘Preventive Nebul...

    Authors: Sophia van der Hoeven, Lorenzo Ball, Federico Constantino, David M. van Meenen, Paolo Pelosi, Ludo F. Beenen, Marcus J. Schultz and Frederique Paulus

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):71

    Content type: Research

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  11. Glucocorticoids (GCs) are stress hormones that regulate developmental and physiological processes and are among the most potent anti-inflammatory drugs to suppress chronic and acute inflammation. GCs act throu...

    Authors: Martin Wepler, Jonathan M. Preuss, Tamara Merz, Oscar McCook, Peter Radermacher, Jan P. Tuckermann and Sabine Vettorazzi

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):37

    Content type: Review

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  12. This review addresses the plausibility of hydrogen sulfide (H2S) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. The re...

    Authors: Tamara Merz, Nicole Denoix, Martin Wepler, Holger Gäßler, David A. C. Messerer, Clair Hartmann, Thomas Datzmann, Peter Radermacher and Oscar McCook

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):33

    Content type: Review

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  13. Sepsis is a syndrome of shock and dysfunction of multiple vital organs that is caused by an uncontrolled immune response to infection and has a high mortality rate. There are no therapies for sepsis, and it ha...

    Authors: Jack Brady, Shahd Horie and John G. Laffey

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):20

    Content type: Review

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  14. In acute respiratory distress syndrome (ARDS), increased pulmonary vascular permeability makes the lung vulnerable to edema. The use of conservative as compared to liberal fluid strategies may increase the num...

    Authors: Renata de S. Mendes, Paolo Pelosi, Marcus J. Schultz, Patricia R. M. Rocco and Pedro L. Silva

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):32

    Content type: Review

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  15. Immune cell activation leads to the acquisition of new functions, such as proliferation, chemotaxis, and cytokine production. These functional changes require continuous metabolic adaption in order to sustain ...

    Authors: Xiaomin Zhang, Fabian Zink, Felix Hezel, Josef Vogt, Ulrich Wachter, Martin Wepler, Maurizio Loconte, Christine Kranz, Andreas Hellmann, Boris Mizaikoff, Peter Radermacher and Clair Hartmann

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):28

    Content type: Review

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  16. Extracellular vesicles (EVs) are small, lipid bilayer-delimited particles of cellular origin that recently gained increasing attention for their potential use as diagnostic biomarkers, and beyond that for thei...

    Authors: Felix Behrens, Johannes Holle, Wolfgang M. Kuebler and Szandor Simmons

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):22

    Content type: Review

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  17. Post cardiac arrest syndrome is associated with high morbidity and mortality, which is related not only to a poor neurological outcome but also to respiratory and cardiovascular dysfunctions. The control of ga...

    Authors: Chiara Robba, Dorota Siwicka-Gieroba, Andras Sikter, Denise Battaglini, Wojciech Dąbrowski, Marcus J. Schultz, Evert de Jonge, Chloe Grim, Patricia RM Rocco and Paolo Pelosi

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):19

    Content type: Review

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  18. Acute ischaemic stroke is associated with a high risk of non-neurological complications, which include respiratory failure, cardiovascular dysfunction, kidney and liver injury, and altered immune and endocrine...

    Authors: Chiara Robba, Denise Battaglini, Cynthia S. Samary, Pedro L. Silva, Lorenzo Ball, Patricia R. M. Rocco and Paolo Pelosi

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):23

    Content type: Review

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  19. In patients with acute respiratory distress syndrome (ARDS), lung recruitment could be maximised with the use of recruitment manoeuvres (RM) or applying a positive end-expiratory pressure (PEEP) higher than wh...

    Authors: Lorenzo Ball, Ary Serpa Neto, Valeria Trifiletti, Maura Mandelli, Iacopo Firpo, Chiara Robba, Marcelo Gama de Abreu, Marcus J. Schultz, Nicolò Patroniti, Patricia R. M. Rocco and Paolo Pelosi

    Citation: Intensive Care Medicine Experimental 2020 8(Suppl 1):39

    Content type: Review

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