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  1. Risk stratification and outcome prediction are crucial for intensive care resource planning. In addressing the large data sets of intensive care unit (ICU) patients, we employed the Explainable Boosting Machin...

    Authors: Andreas Körner, Benjamin Sailer, Sibel Sari-Yavuz, Helene A. Haeberle, Valbona Mirakaj, Alice Bernard, Peter Rosenberger and Michael Koeppen
    Citation: Intensive Care Medicine Experimental 2024 12:55
  2. Continuous monitoring of mitral annular plane systolic excursion (MAPSE) using transesophageal echocardiography (TEE) may improve the evaluation of left ventricular (LV) function in postoperative intensive car...

    Authors: Jinyang Yu, Anders Austlid Taskén, Erik Andreas Rye Berg, Tomas Dybos Tannvik, Katrine Hordnes Slagsvold, Idar Kirkeby-Garstad, Bjørnar Grenne, Gabriel Kiss and Svend Aakhus
    Citation: Intensive Care Medicine Experimental 2024 12:54
  3. Dipeptidyl peptidase 3 (DPP3) is a ubiquitous cytosolic enzyme released into the bloodstream after tissue injury, that can degrade angiotensin II. High concentrations of circulating DPP3 (cDPP3) have been asso...

    Authors: Bruno Garcia, Benoit ter Schiphorst, Karine Santos, Fuhong Su, Laurence Dewachter, Francisco Vasques-Nóvoa, Estela Rocha-Oliveira, Roberto Roncon-Albuquerque Jr., Theo Uba, Oliver Hartmann, Adrien Picod, Feriel Azibani, Jacques Callebert, Serge Goldman, Filippo Annoni, Raphaël Favory…
    Citation: Intensive Care Medicine Experimental 2024 12:53
  4. Recirculation is a common problem in venovenous extracorporeal membrane oxygenation (VV ECMO) and may limit the effect of ECMO treatment due to less efficient blood oxygenation or unfavorable ECMO and ventilat...

    Authors: Lars Prag Antonsen, Andreas Espinoza, Per Steinar Halvorsen, Itai Schalit, Harald Bergan, Didrik Lilja and Svein Aslak Landsverk
    Citation: Intensive Care Medicine Experimental 2024 12:51
  5. Pancreatic stone protein (PSP) exhibits potential as a plasma biomarker for infection diagnosis and risk stratification in critically ill patients, but its significance in nosocomial infection and intensive ca...

    Authors: Diede Verlaan, Lennie P. G. Derde, Tom van der Poll, Marc J. M. Bonten and Olaf L. Cremer
    Citation: Intensive Care Medicine Experimental 2024 12:50
  6. We tested the ability of a physiologically driven minimally invasive closed-loop algorithm, called Resuscitation based on Functional Hemodynamic Monitoring (ReFit), to stabilize for up to 3 h a porcine model o...

    Authors: Michael R. Pinsky, Hernando Gomez, Francis X. Guyette, Leonard Weiss, Artur Dubrawski, Jim Leonard, Robert MacLachlan, Lisa Gordon, Theodore Lagattuta, David Salcido and Ronald Poropatich
    Citation: Intensive Care Medicine Experimental 2024 12:44
  7. Catecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock. However, excessive or sustained adrenergic activation drives detrimental ca...

    Authors: Christine Bode, Sebastian Preissl, Lutz Hein and Achim Lother
    Citation: Intensive Care Medicine Experimental 2024 12:48
  8. Therapeutic drug monitoring (TDM) of anti-infectives such as linezolid is routinely performed in blood of intensive care unit (ICU) patients to optimize target attainment. However, the concentration at the sit...

    Authors: Diana Rebholz, Uwe Liebchen, Michael Paal, Michael Vogeser, Johannes Starp, Caroline Gräfe, Clara I. Brozat, Felix L. Happich, Katharina Habler and Christina Scharf
    Citation: Intensive Care Medicine Experimental 2024 12:47
  9. Assessment of dynamic parameters to guide fluid administration is one of the mainstays of current resuscitation strategies. Each test has its own limitations, but passive leg raising (PLR) has emerged as one o...

    Authors: Mario Bruna, Sebastian Alfaro, Felipe Muñoz, Liliana Cisternas, Cecilia Gonzalez, Rodrigo Conlledo, Rodrigo Ulloa-Morrison, Marcos Huilcaman, Jaime Retamal, Ricardo Castro, Philippe Rola, Adrian Wong, Eduardo R. Argaiz, Roberto Contreras, Glenn Hernandez and Eduardo Kattan
    Citation: Intensive Care Medicine Experimental 2024 12:46
  10. Lung volume optimization maneuvers (LVOM) are necessary to make physiologic use of high-frequency oscillatory ventilation (HFOV), but lung behavior during such maneuvers has not been studied to determine lung ...

    Authors: Pauline de Jager, Alette A. Koopman, Dick G. Markhorst and Martin C. J. Kneyber
    Citation: Intensive Care Medicine Experimental 2024 12:42
  11. The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired ...

    Authors: Rolf Erlebach, Alix Buhlmann, Rea Andermatt, Benjamin Seeliger, Klaus Stahl, Christian Bode, Reto Schuepbach, Pedro David Wendel-Garcia and Sascha David
    Citation: Intensive Care Medicine Experimental 2024 12:41
  12. To assess the incidences of Herpes Simplex-1 and 2 (HSV-1, HSV-2), Cytomegalovirus (CMV), Epstein–Barr Virus (EBV) reactivations in critically ill COVID-19 patients. To determine the association between viral ...

    Authors: Alessia Mattei, Lorenzo Schiavoni, Elisabetta Riva, Massimo Ciccozzi, Roberta Veralli, Angela Urselli, Vincenzo Citriniti, Antonio Nenna, Giuseppe Pascarella, Fabio Costa, Rita Cataldo, Felice Eugenio Agrò and Massimiliano Carassiti
    Citation: Intensive Care Medicine Experimental 2024 12:40
  13. In selected cases of cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is combined with trans valvular micro axial flow pumps (ECMELLA). Observational studies indicate that ECMELL...

    Authors: Emilie Gregers, Peter H. Frederiksen, Nanna L. J. Udesen, Louise Linde, Ann Banke, Amalie L. Povlsen, Jeppe P. Larsen, Christian Hassager, Lisette O. Jensen, Jens F. Lassen, Henrik Schmidt, Hanne B. Ravn, Peter M. H. Heegaard and Jacob E. Møller
    Citation: Intensive Care Medicine Experimental 2024 12:39
  14. The use of hemoadsorption (HA) has become popular in the treatment of vasoplegic states associated with massive cytokine release, including septic shock. However, this approach does not seem to be based on rob...

    Authors: Vaclav Tegl, Jan Horak, Lukas Nalos, Michala Horakova, Milan Stengl, Martin Matejovic and Jan Benes
    Citation: Intensive Care Medicine Experimental 2024 12:38
  15. Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in cl...

    Authors: Bashar N. Hilderink, Reinier F. Crane, Bas van den Bogaard, Janesh Pillay and Nicole P. Juffermans
    Citation: Intensive Care Medicine Experimental 2024 12:37
  16. In refractory out-of-hospital cardiac arrest, the patient is commonly transported to hospital with mechanical continuous chest compressions (CCC). Limited data are available on the optimal ventilation strategy...

    Authors: Jukka Kopra, Erik Litonius, Pirkka T. Pekkarinen, Merja Laitinen, Juho A. Heinonen, Luca Fontanelli and Markus B. Skrifvars
    Citation: Intensive Care Medicine Experimental 2024 12:36
  17. The same principle behind pulse wave analysis can be applied on the pulmonary artery (PA) pressure waveform to estimate right ventricle stroke volume (RVSV). However, the PA pressure waveform might be influenc...

    Authors: Arnoldo Santos, M. Ignacio Monge-García, João Batista Borges, Jaime Retamal, Gerardo Tusman, Anders Larsson and Fernando Suarez-Sipmann
    Citation: Intensive Care Medicine Experimental 2024 12:34
  18. Liver function of intensive care patients is routinely monitored by static blood pathology. For specific indications, liver specific cytochrome activity may be measured by the commercially available maximum li...

    Authors: Thomas Köhler, Elke Schwier, Janina Praxenthaler, Carmen Kirchner, Günther Winde, Björn Koos and Dietrich Henzler
    Citation: Intensive Care Medicine Experimental 2024 12:33
  19. Reinforcement learning (RL) holds great promise for intensive care medicine given the abundant availability of data and frequent sequential decision-making. But despite the emergence of promising algorithms, R...

    Authors: Luca F. Roggeveen, Ali el Hassouni, Harm-Jan de Grooth, Armand R. J. Girbes, Mark Hoogendoorn and Paul W. G. Elbers
    Citation: Intensive Care Medicine Experimental 2024 12:32
  20. The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney f...

    Authors: Simone Gattarello, Fabio Lombardo, Federica Romitti, Rosanna D’Albo, Mara Velati, Isabella Fratti, Tommaso Pozzi, Rosmery Nicolardi, Antonio Fioccola, Mattia Busana, Francesca Collino, Peter Herrmann, Luigi Camporota, Michael Quintel, Onnen Moerer, Leif Saager…
    Citation: Intensive Care Medicine Experimental 2024 12:31
  21. Mechanical power (MP) is the energy delivered by the ventilator to the respiratory system and combines factors related to the development of ventilator-induced lung injury (VILI). Flow-controlled ventilation (...

    Authors: Julien P. Van Oosten, Juliette E. Francovich, Peter Somhorst, Philip van der Zee, Henrik Endeman, Diederik A. M. P. J. Gommers and Annemijn H. Jonkman
    Citation: Intensive Care Medicine Experimental 2024 12:30
  22. Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predi...

    Authors: Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J. Dwivedi, Ji Zhou, Manoj M. Lalu, Asher A. Mendelson, Braedon McDonald, Colin A. Kretz, Alison E. Fox-Robichaud and Patricia C. Liaw
    Citation: Intensive Care Medicine Experimental 2024 12:28
  23. Aim of this study was to evaluate feasibility and effects of individualised flow-controlled ventilation (FCV), based on compliance guided pressure settings, compared to standard of pressure-controlled ventilat...

    Authors: Julia Abram, Patrick Spraider, Julian Wagner, Gabriel Putzer, Manuela Ranalter, Sarah Rinner, Andrea Katharina Lindner, Bernhard Glodny, Tobias Hell, Tom Barnes, Dietmar Enk and Judith Martini
    Citation: Intensive Care Medicine Experimental 2024 12:27
  24. Coronary artery calcification (CAC) is associated with poor outcome in critically ill patients. A deterioration in cardiac conduction and loss of myocardial tissue could be an underlying cause. Vectorcardiogra...

    Authors: Eda Aydeniz, Frank van Rosmalen, Jip de Kok, Bibi Martens, Alma M. A. Mingels, Mustafa Emin Canakci, Casper Mihl, Kevin Vernooy, Frits W. Prinzen, Joachim E. Wildberger, Iwan C. C. van der Horst, Bas C. T. van Bussel and Rob G. H. Driessen
    Citation: Intensive Care Medicine Experimental 2024 12:26
  25. Expiratory time constant (τ) objectively assesses the speed of exhalation and can guide adjustments of the respiratory rate and the I:E ratio with the goal of achieving complete exhalation. Multiple methods of ob...

    Authors: Filip Depta, Caitlyn M. Chiofolo, Nicolas W. Chbat, Neil R. Euliano, Michael A. Gentile, Dušan Rybár, Viliam Donič and Marko Zdravkovic
    Citation: Intensive Care Medicine Experimental 2024 12:25
  26. Glucocorticoids are commonly used in patients with or at-risk for acute respiratory distress syndrome (ARDS), but optimal use remains unclear despite well-conducted clinical trials. We performed a secondary an...

    Authors: Nameer Al-Yousif, Seyed M. Nouraie, Matthew J. Broerman, Yingze Zhang, Tomeka L. Suber, John Evankovich, William G. Bain, Georgios D. Kitsios, Bryan J. McVerry and Faraaz A. Shah
    Citation: Intensive Care Medicine Experimental 2024 12:24
  27. Disorders of the gut microbiome could be responsible for the progression of multiple organ dysfunction syndrome. In this study, we examined the effect of esmolol on the gut microbiome in a rat model of sepsis ...

    Authors: Bo Yao, Fu-hua Wang, Xiao-ning Han, Jun Yang, Ping Xue, Qi Qi, Guang-yao Wei and Jin-yan Xing
    Citation: Intensive Care Medicine Experimental 2024 12:22
  28. Obtaining a properly fitting non-invasive ventilation (NIV) mask to treat acute respiratory failure is a major challenge, especially in young children and patients with craniofacial abnormalities. Personalizat...

    Authors: Rosemijne R. W. P. Pigmans, Rozalinde Klein-Blommert, Monica C. van Gestel, Dick G. Markhorst, Peter Hammond, Pim Boomsma, Tim Daams, Julia M. A. de Jong, Paul M. Heeman, Job B. M. van Woensel, Coen D. Dijkman and Reinout A. Bem
    Citation: Intensive Care Medicine Experimental 2024 12:21
  29. Lung- and diaphragm-protective (LDP) ventilation may prevent diaphragm atrophy and patient self-inflicted lung injury in acute respiratory failure, but feasibility is uncertain. The objectives of this study we...

    Authors: Damian Ratano, Binghao Zhang, Jose Dianti, Dimitrios Georgopoulos, Laurent J. Brochard, Timothy C. Y. Chan and Ewan C. Goligher
    Citation: Intensive Care Medicine Experimental 2024 12:20
  30. Acute respiratory distress syndrome (ARDS) is a form of respiratory failure stemming from various underlying conditions that ultimately lead to inflammation and lung fibrosis. Bromodomain and Extra-Terminal mo...

    Authors: Manuela Iten, Camille Gschwend, Alessandro Ostini, David Robert Cameron, Christine Goepfert, David Berger and Matthias Haenggi
    Citation: Intensive Care Medicine Experimental 2024 12:19
  31. Several studies have demonstrated associations between greater rate/volume of intravenous (IV) fluid administration and poorer clinical outcomes. One postulated mechanism for harm from exogenous fluids is shed...

    Authors: Sara Sukudom, Lisa Smart and Stephen Macdonald
    Citation: Intensive Care Medicine Experimental 2024 12:16
  32. Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the “obesity paradox...

    Authors: Mikaela Eng, Keshikaa Suthaaharan, Logan Newton, Fatima Sheikh and Alison Fox-Robichaud
    Citation: Intensive Care Medicine Experimental 2024 12:15

    The Correction to this article has been published in Intensive Care Medicine Experimental 2024 12:52

  33. Authors: Raghavan Murugan, Kianoush Kashani and Paul M. Palevsky
    Citation: Intensive Care Medicine Experimental 2024 12:17

    The original article was published in Intensive Care Medicine Experimental 2024 12:18

    The Correspondence to this article has been published in Intensive Care Medicine Experimental 2024 12:18

  34. ECPELLA, a combination of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) and Impella, a percutaneous left ventricular (LV) assist device, has emerged as a novel therapeutic option in patients wi...

    Authors: Hiroki Matsushita, Keita Saku, Takuya Nishikawa, Shohei Yokota, Kei Sato, Hidetaka Morita, Yuki Yoshida, Masafumi Fukumitsu, Kazunori Uemura, Toru Kawada and Ken Yamaura
    Citation: Intensive Care Medicine Experimental 2024 12:13
  35. Exhaled volatile organic compounds (VOCs), particularly hydrocarbons from oxidative stress-induced lipid peroxidation, are associated with hyperoxia exposure. However, important heterogeneity amongst identifie...

    Authors: Thijs A. Lilien, Dominic W. Fenn, Paul Brinkman, Laura A. Hagens, Marry R. Smit, Nanon F. L. Heijnen, Job B. M. van Woensel, Lieuwe D. J. Bos and Reinout A. Bem
    Citation: Intensive Care Medicine Experimental 2024 12:14
  36. How assisted spontaneous breathing should be used during acute respiratory distress syndrome is questioned. Recent evidence suggests that high positive end-expiratory pressure (PEEP) may limit the risk of pati...

    Authors: Hannes Widing, Mariangela Pellegrini, Elena Chiodaroli, Per Persson, Katarina Hallén and Gaetano Perchiazzi
    Citation: Intensive Care Medicine Experimental 2024 12:10
  37. Continuous renal replacement therapy (CRRT) support is crucial for critically ill patients and it is underexplored in specific situations. Experimental CRRT offers a means to gain insights into these scenarios...

    Authors: Yuri de Albuquerque Pessoa dos Santos, Viviane Flor Park, Luis Carlos Maia Cardozo Junior, Bruno Adler Maccagnan Pinheiro Besen, Pedro Vitale Mendes and Marcelo Park
    Citation: Intensive Care Medicine Experimental 2024 12:9
  38. The models used to investigate the pathophysiological mechanisms of acute critical illness are not limited to mammalian species. The zebrafish (Danio rerio) is a popular model organism for studying diseases due t...

    Authors: Kensuke Fujii, Kazuma Yamakawa, Yuriko Takeda, Natsuko Okuda, Akira Takasu and Fumihito Ono
    Citation: Intensive Care Medicine Experimental 2024 12:8
  39. Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair and vascular endothelial-protect...

    Authors: Tomotaka Miura, Tomoki Okuda, Kodai Suzuki, Hideshi Okada, Hiroyuki Tomita, Chihiro Takada, Kosuke Mori, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Yohei Fukuda, Hirotsugu Fukuda, Ayane Nishio, Yuki Kawasaki, Ayumi Kuroda, Keiko Suzuki…
    Citation: Intensive Care Medicine Experimental 2024 12:7
  40. Lung weight is an important study endpoint to assess lung edema in porcine experiments on acute respiratory distress syndrome and ventilatory induced lung injury. Evidence on the relationship between lung–body...

    Authors: Antonio Fioccola, Rosmery Valentina Nicolardi, Tommaso Pozzi, Isabella Fratti, Federica Romitti, Francesca Collino, Verena Reupke, Gianluigi Li Bassi, Alessandro Protti, Alessandro Santini, Massimo Cressoni, Mattia Busana, Onnen Moerer, Luigi Camporota and Luciano Gattinoni
    Citation: Intensive Care Medicine Experimental 2024 12:6
  41. Respiratory quotient (RQ) is an important variable when assessing metabolic status in intensive care patients. However, analysis of RQ requires cumbersome technical equipment. The aim of the current study was ...

    Authors: Jacob Karlsson, Anders Svedmyr, Mats Wallin, Magnus Hallbäck and Per-Arne Lönnqvist
    Citation: Intensive Care Medicine Experimental 2024 12:11