Meeting abstracts
Intensive Care Medicine Experimental 2017 5(Suppl 2):44
Published on: 20 September 2017
This article is part of a Supplement: Volume 5 Supplement 2
Articles
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Research
Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS
Systemic inflammatory response syndrome (SIRS) is a clinical syndrome following inflammation. Clinically, it is difficult to distinguish SIRS following an infection, i.e., sepsis, from non-infectious SIRS. Mye...
Intensive Care Medicine Experimental 2017 5:43
Published on: 15 September 2017
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Fluid loading and norepinephrine infusion mask the left ventricular preload decrease induced by pleural effusion
Pleural effusion (PLE) may lead to low blood pressure and reduced cardiac output. Low blood pressure and reduced cardiac output are often treated with fluid loading and vasopressors. This study aimed to determ...
Intensive Care Medicine Experimental 2017 5:42
Published on: 11 September 2017
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Meeting abstracts
Intensive Care Medicine Experimental 2017 5(Suppl 1):37
Published on: 11 September 2017
This article is part of a Supplement: Volume 5 Supplement 1
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Research
An extracorporeal carbon dioxide removal (ECCO2R) device operating at hemodialysis blood flow rates
Extracorporeal carbon dioxide removal (ECCO2R) systems have gained clinical appeal as supplemental therapy in the treatment of acute and chronic respiratory injuries with low tidal volume or non-invasive ventilat...
Intensive Care Medicine Experimental 2017 5:41
Published on: 6 September 2017
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Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model
Mechanical ventilation with positive end expiratory pressure and low tidal volume, i.e. protective ventilation, is recommended in patients with acute respiratory distress syndrome. However, the effect of prote...
Intensive Care Medicine Experimental 2017 5:40
Published on: 31 August 2017
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Whole blood microRNA markers are associated with acute respiratory distress syndrome
MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagno...
Intensive Care Medicine Experimental 2017 5:38
Published on: 30 August 2017
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Automated bedside flow cytometer for mHLA-DR expression measurement: a comparison study with reference protocol
In various ICU conditions, measurement of diminished expression of human leukocyte antigen-DR on circulating monocytes (mHLA-DR) by flow cytometry appears to be a reliable marker of acquired immunosuppression....
Intensive Care Medicine Experimental 2017 5:39
Published on: 30 August 2017
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Hemoadsorption corrects hyperresistinemia and restores anti-bacterial neutrophil function
Mounting evidence suggests that sepsis-induced morbidity and mortality are due to both immune activation and immunosuppression. Resistin is an inflammatory cytokine and uremic toxin. Septic hyperresistinemia (...
Intensive Care Medicine Experimental 2017 5:36
Published on: 4 August 2017
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Optimal esophageal balloon volume for accurate estimation of pleural pressure at end-expiration and end-inspiration: an in vitro bench experiment
Esophageal pressure, used as a surrogate for pleural pressure, is commonly measured by air-filled balloon, and the accuracy of measurement depends on the proper balloon volume. It has been found that larger fi...
Intensive Care Medicine Experimental 2017 5:35
Published on: 2 August 2017
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Impact of membrane lung surface area and blood flow on extracorporeal CO2 removal during severe respiratory acidosis
Veno-venous extracorporeal CO2 removal (vv-ECCO2R) is increasingly being used in the setting of acute respiratory failure. Blood flow rates through the device range from 200 ml/min to more than 1500 ml/min, and t...
Intensive Care Medicine Experimental 2017 5:34
Published on: 1 August 2017
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Heart rate variability in critical care medicine: a systematic review
Heart rate variability (HRV) has been used to assess cardiac autonomic activity in critically ill patients, driven by translational and biomarker research agendas. Several clinical and technical factors can in...
Intensive Care Medicine Experimental 2017 5:33
Published on: 12 July 2017
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Sepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study
Platelets have been involved in both immune surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to...
Intensive Care Medicine Experimental 2017 5:32
Published on: 12 July 2017
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Evaluation of an ADVanced Organ Support (ADVOS) system in a two-hit porcine model of liver failure plus endotoxemia
Novel extracorporeal procedures are constantly being developed and evaluated for use in patients with sepsis. Preclinical evaluation of such procedures usually requires testing in large animal models. In the p...
Intensive Care Medicine Experimental 2017 5:31
Published on: 4 July 2017
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Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock
Cystathionine-γ-lyase (CSE) was shown to have a regulatory role in glucose metabolism. Circulatory shock can induce metabolic stress, thereby leading to hyperglycemia and mitochondrial dysfunction. In vitro da...
Intensive Care Medicine Experimental 2017 5:30
Published on: 14 June 2017
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The novel nitric oxide donor PDNO attenuates ovine ischemia-reperfusion induced renal failure
Renal ischemia-reperfusion injury is a common cause of acute kidney injury in intensive care and surgery. Recently, novel organic mononitrites of 1,2-propanediol (PDNO) were synthesized and shown to rapidly an...
Intensive Care Medicine Experimental 2017 5:29
Published on: 9 June 2017
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Effect of continuous dialysis on blood pH in acidemic hypercapnic animals with severe acute kidney injury: a randomized experimental study comparing high vs. low bicarbonate affluent
Controlling blood pH during acute ventilatory failure and hypercapnia in individuals suffering from severe acute kidney injury (AKI) and undergoing continuous renal replacement therapy (CRRT) is of paramount i...
Intensive Care Medicine Experimental 2017 5:28
Published on: 30 May 2017
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Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes
Mechanical ventilation and hyperoxia have the potential to independently promote lung injury and inflammation. Our purpose was to study both time- and dose-dependent effects of supplemental oxygen in an experi...
Intensive Care Medicine Experimental 2017 5:27
Published on: 26 May 2017
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Assessment of endothelial cell function and physiological microcirculatory reserve by video microscopy using a topical acetylcholine and nitroglycerin challenge
Assessment of the microcirculation is a promising target for the hemodynamic management of critically ill patients. However, just as the sole reliance on macrocirculatory parameters, single static parameters o...
Intensive Care Medicine Experimental 2017 5:26
Published on: 18 May 2017
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The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model
Acute respiratory distress syndrome causes a heterogeneous lung injury with normal and acutely injured lung tissue in the same lung. Improperly adjusted mechanical ventilation can exacerbate ARDS causing a sec...
Intensive Care Medicine Experimental 2017 5:25
Published on: 12 May 2017
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Systemic and microcirculatory effects of blood transfusion in experimental hemorrhagic shock
The microvascular reperfusion injury after retransfusion has not been completely characterized. Specifically, the question of heterogeneity among different microvascular beds needs to be addressed. In addition...
Intensive Care Medicine Experimental 2017 5:24
Published on: 21 April 2017
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Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis
Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing se...
Intensive Care Medicine Experimental 2017 5:23
Published on: 20 April 2017
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The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances
Hyperoxia, an arterial oxygen pressure of more than 100 mmHg or 13% O2, frequently occurs in hospitalized patients due to administration of supplemental oxygen. Increasing evidence suggests that hyperoxia induces...
Intensive Care Medicine Experimental 2017 5:22
Published on: 13 April 2017
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Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis
Recognition of cardiomyopathy in sepsis can be challenging due to the limitations of conventional measures such as ejection fraction (EF) and fractional shortening (FS) in the context of variable preload and a...
Intensive Care Medicine Experimental 2017 5:21
Published on: 12 April 2017
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Extracorporeal CO2 removal by hemodialysis: in vitro model and feasibility
Critically ill patients with acute respiratory distress syndrome and acute exacerbations of chronic obstructive pulmonary disease often develop hypercapnia and require mechanical ventilation. Extracorporeal ca...
Intensive Care Medicine Experimental 2017 5:20
Published on: 7 April 2017
