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Research
Mounting evidence suggests that sepsis-induced morbidity and mortality are due to both immune activation and immunosuppression. Resistin is an inflammatory cytokine and uremic toxin. Septic hyperresistinemia (...
Intensive Care Medicine Experimental 2017 5:36
Published on: 4 August 2017
Research
Esophageal pressure, used as a surrogate for pleural pressure, is commonly measured by air-filled balloon, and the accuracy of measurement depends on the proper balloon volume. It has been found that larger fi...
Intensive Care Medicine Experimental 2017 5:35
Published on: 2 August 2017
Research
Veno-venous extracorporeal CO2 removal (vv-ECCO2R) is increasingly being used in the setting of acute respiratory failure. Blood flow rates through the device range from 200 ml/min to more than 1500 ml/min, and t...
Intensive Care Medicine Experimental 2017 5:34
Published on: 1 August 2017
Research
Heart rate variability (HRV) has been used to assess cardiac autonomic activity in critically ill patients, driven by translational and biomarker research agendas. Several clinical and technical factors can in...
Intensive Care Medicine Experimental 2017 5:33
Published on: 12 July 2017
Research
Platelets have been involved in both immune surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to...
Intensive Care Medicine Experimental 2017 5:32
Published on: 12 July 2017
Research
Novel extracorporeal procedures are constantly being developed and evaluated for use in patients with sepsis. Preclinical evaluation of such procedures usually requires testing in large animal models. In the p...
Intensive Care Medicine Experimental 2017 5:31
Published on: 4 July 2017
Research
Cystathionine-γ-lyase (CSE) was shown to have a regulatory role in glucose metabolism. Circulatory shock can induce metabolic stress, thereby leading to hyperglycemia and mitochondrial dysfunction. In vitro da...
Intensive Care Medicine Experimental 2017 5:30
Published on: 14 June 2017
Research
Renal ischemia-reperfusion injury is a common cause of acute kidney injury in intensive care and surgery. Recently, novel organic mononitrites of 1,2-propanediol (PDNO) were synthesized and shown to rapidly an...
Intensive Care Medicine Experimental 2017 5:29
Published on: 9 June 2017
Research
Controlling blood pH during acute ventilatory failure and hypercapnia in individuals suffering from severe acute kidney injury (AKI) and undergoing continuous renal replacement therapy (CRRT) is of paramount i...
Intensive Care Medicine Experimental 2017 5:28
Published on: 30 May 2017
Research
Mechanical ventilation and hyperoxia have the potential to independently promote lung injury and inflammation. Our purpose was to study both time- and dose-dependent effects of supplemental oxygen in an experi...
Intensive Care Medicine Experimental 2017 5:27
Published on: 26 May 2017
Research
Assessment of the microcirculation is a promising target for the hemodynamic management of critically ill patients. However, just as the sole reliance on macrocirculatory parameters, single static parameters o...
Intensive Care Medicine Experimental 2017 5:26
Published on: 18 May 2017
Research
Acute respiratory distress syndrome causes a heterogeneous lung injury with normal and acutely injured lung tissue in the same lung. Improperly adjusted mechanical ventilation can exacerbate ARDS causing a sec...
Intensive Care Medicine Experimental 2017 5:25
Published on: 12 May 2017
Research
The microvascular reperfusion injury after retransfusion has not been completely characterized. Specifically, the question of heterogeneity among different microvascular beds needs to be addressed. In addition...
Intensive Care Medicine Experimental 2017 5:24
Published on: 21 April 2017
Research
Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing se...
Intensive Care Medicine Experimental 2017 5:23
Published on: 20 April 2017
Research
Hyperoxia, an arterial oxygen pressure of more than 100 mmHg or 13% O2, frequently occurs in hospitalized patients due to administration of supplemental oxygen. Increasing evidence suggests that hyperoxia induces...
Intensive Care Medicine Experimental 2017 5:22
Published on: 13 April 2017
Research
Recognition of cardiomyopathy in sepsis can be challenging due to the limitations of conventional measures such as ejection fraction (EF) and fractional shortening (FS) in the context of variable preload and a...
Intensive Care Medicine Experimental 2017 5:21
Published on: 12 April 2017
Research
Critically ill patients with acute respiratory distress syndrome and acute exacerbations of chronic obstructive pulmonary disease often develop hypercapnia and require mechanical ventilation. Extracorporeal ca...
Intensive Care Medicine Experimental 2017 5:20
Published on: 7 April 2017
Research
Quantitative lung computed tomography (CT) provides fundamental information about lung aeration in critically ill patients. We tested a scanning protocol combining reduced number of CT slices and tube current,...
Intensive Care Medicine Experimental 2017 5:19
Published on: 4 April 2017
Research
Overwhelming activation of granulocytes and monocytes is central to inflammatory responses during sepsis. Granulocyte and monocyte adsorptive apheresis (GMA) is an extracorporeal leukocyte apheresis device fil...
Intensive Care Medicine Experimental 2017 5:18
Published on: 24 March 2017
Research
Downregulation of the hydrogen sulfide (H2S)-producing enzymes cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and/or 3-mercaptopyruvate sulfurtransferase (3-MST) is associated with chronic cardiovas...
Intensive Care Medicine Experimental 2017 5:17
Published on: 21 March 2017
Research
In prolonged non-obese critically ill patients, preservation of adipose tissue is prioritized over that of the skeletal muscle and coincides with increased adipogenesis. However, we recently demonstrated that ...
Intensive Care Medicine Experimental 2017 5:16
Published on: 16 March 2017
Research
Extracellular superoxide dismutase (ECSOD) protects nitric oxide (NO) bioavailability by decreasing superoxide levels and preventing peroxynitrite generation, which is important in maintaining renal blood flow...
Intensive Care Medicine Experimental 2017 5:15
Published on: 16 March 2017
Research
Controlled mechanical ventilation (CMV) is associated with diaphragm dysfunction. Dysfunction results from muscle atrophy and injury of diaphragm muscle fibers. Enhanced proteolysis and reduced protein synthes...
Intensive Care Medicine Experimental 2017 5:14
Published on: 14 March 2017
Research
Mesenchymal stem cells (MSCs) might act as fine-tuners of inflammation during acute lung injury. We assessed the effects of adoptive transfer of MSCs in acid aspiration acute lung injury and explored the role ...
Intensive Care Medicine Experimental 2017 5:13
Published on: 6 March 2017
Research
Low hemoglobin concentration (Hb) and low mean arterial blood pressure (MAP) impact outcomes in critically ill patients. We utilized an experimental model of “normotensive” vs. “hypotensive” acute hemodilution...
Intensive Care Medicine Experimental 2017 5:12
Published on: 1 March 2017
