Articles

Regional venous–arterial CO₂ to arterial–venous O₂ content difference ratio in experimental circulatory shock and hypoxia

Venous–arterial carbon dioxide (CO₂) to arterial–venous oxygen (O₂) content difference ratio (Cv-aCO₂/Ca-vO₂) > 1 is supposed to be both sensitive and specific for anaerobic metabolism. What regional hemodynamic ...

Authors: Thiago Domingos Corrêa, Adriano José Pereira, Jukka Takala and Stephan Mathias Jakob

Veno-venous ECMO as a platform to evaluate lung lavage and surfactant replacement therapy in an animal model of severe ARDS

There are limited therapeutic options directed at the underlying pathological processes in acute respiratory distress syndrome (ARDS). Experimental therapeutic strategies have targeted the protective systems t...

Authors: Robert Qaqish, Yui Watanabe, Marcos Galasso, Cara Summers, A adil Ali, Mamoru Takahashi, Anajara Gazzalle, Mingyao Liu, Shaf Keshavjee, Marcelo Cypel and Lorenzo Del Sorbo

Neuromuscular blocking agents in acute respiratory distress syndrome: updated systematic review and meta-analysis of randomized trials

Existing clinical practice guidelines support the use of neuromuscular blocking agents (NMBA) in acute respiratory distress syndrome (ARDS); however, a recent large randomized clinical trial (RCT) has question...

Authors: Nehal Tarazan, Moayad Alshehri, Sameer Sharif, Zainab Al Duhailib, Morten Hylander Møller, Emilie Belley-Cote, Mohammed Alshahrani, John Centofanti, Lauralyn McIntyre, Bandar Baw, Maureen Meade and Waleed Alhazzani

Electrolyte-based calculation of fluid shifts after infusing 0.9% saline in severe hyperglycemia

Early treatment of severe hyperglycemia involves large shifts of body fluids that entail a risk of hemodynamic instability. We studied the feasibility of applying a new electrolyte equation that estimates the ...

Authors: Robert Svensson, Joachim Zdolsek, Marcus Malm and Robert G. Hahn

Right ventricular stroke volume assessed by pulmonary artery pulse contour analysis

Stroke volume measurement should provide estimates of acute treatment responses. The current pulse contour method estimates left ventricle stroke volume. Heart-lung interactions change right ventricular stroke...

Authors: David Berger, Jan Hobi, Per W. Möller, Matthias Haenggi, Jukka Takala and Stephan M. Jakob

Letter to the Editor: Response to Luke Fletcher and Philip Peyton regarding “Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients”

Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J. Kenneth Baillie

The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung

The ex vivo human perfused lung model has enabled optimizing donor lungs for transplantation and delineating mechanisms of lung injury. Perfusate and airspace biomarkers are a proxy of the lung response to exp...

Authors: Aleksandra Leligdowicz, James T. Ross, Nicolas Nesseler and Michael A. Matthay

Diagnostic characteristics of 11 formulae for calculating corrected flow time as measured by a wearable Doppler patch

Change of the corrected flow time (Ftc) is a surrogate for tracking stroke volume (SV) in the intensive care unit. Multiple Ftc equations have been proposed; many have not had their diagnostic characteristics ...

Authors: Jon-Émile S. Kenny, Igor Barjaktarevic, David C. Mackenzie, Andrew M. Eibl, Matthew Parrotta, Bradley F. Long and Joseph K. Eibl

The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients

Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF-α) after ex-vivo who...

Authors: Gabrielle Levin, J. Gordon Boyd, Andrew Day, Miranda Hunt, David M. Maslove, Patrick Norman, Nicole O’Callaghan, Stephanie Sibley and John Muscedere

The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1α?

Authors: Andreas Koch, Wataru Kähler, Sebastian Klapa, Bente Grams and Pieter- Jan A. M. van Ooij

A mock circulation loop to test extracorporeal CO₂ elimination setups

Extracorporeal carbon dioxide removal (ECCO₂R) is a promising yet limited researched therapy for hypercapnic respiratory failure in acute respiratory distress syndrome and exacerbated chronic obstructive pulmonar...

Authors: Leonie S. Schwärzel, Anna M. Jungmann, Nicole Schmoll, Frederik Seiler, Ralf M. Muellenbach, Joachim Schenk, Quoc Thai Dinh, Robert Bals, Philipp M. Lepper and Albert J. Omlor

Repeated measures of Heparin-binding protein (HBP) and procalcitonin during septic shock: biomarker kinetics and association with cardiovascular organ dysfunction

Heparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability and a promising prognostic biomarker in sepsis. This exploratory ...

Authors: Jonas Tverring, Niklas Nielsen, Josef Dankiewicz, Adam Linder, Fredrik Kahn and Per Åkesson

Intravenous calcium as a pressor in a swine model of hypoxic pseudo-pulseless electrical mechanical activity—a preliminary report

Pseudo-pulseless electrical activity (pseudo-PEA) is a lifeless form of profound cardiac shock characterized by measurable cardiac mechanical activity without clinically detectable pulses. Pseudo-PEA may const...

Authors: Alexander L. Lindqwister, Joshua W. Lampe, Jeffrey R. Gould, Christopher L. Kaufman, Karen L. Moodie and Norman A. Paradis

Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia

The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendor...

Authors: Nora S. Wolff, Max C. Jacobs, Bastiaan W. Haak, Joris J. T. H. Roelofs, Alex F. de Vos, Floor Hugenholtz and W. Joost Wiersinga

In vivo testing of the low-flow CO₂ removal application of a compact, platform respiratory device

Non-invasive and lung-protective ventilation techniques may improve outcomes for patients with an acute exacerbation of chronic obstructive pulmonary disease or moderate acute respiratory distress syndrome by ...

Authors: Alexandra G. May, Ryan A. Orizondo, Brian J. Frankowski, Sang-Ho Ye, Ergin Kocyildirim, William R. Wagner, Jonathan D’Cunha and William J. Federspiel

Cerebral autoregulation and neurovascular coupling are progressively impaired during septic shock: an experimental study

Alteration of the mechanisms of cerebral blood flow (CBF) regulation might contribute to the pathophysiology of sepsis-associated encephalopathy (SAE). However, previous clinical studies on dynamic cerebral au...

Authors: Lorenzo Ferlini, Fuhong Su, Jacques Creteur, Fabio Silvio Taccone and Nicolas Gaspard

Unloading using Impella CP during profound cardiogenic shock caused by left ventricular failure in a large animal model: impact on the right ventricle

This study aimed to assess right ventricular (RV) function during cardiogenic shock due to acute left ventricular (LV) failure, including during LV unloading with Impella CP and an added moderate dose of norep...

Authors: Jakob Josiassen, Ole Kristian Lerche Helgestad, Nanne Louise Junker Udesen, Ann Banke, Peter Hartmund Frederiksen, Janus Adler Hyldebrandt, Henrik Schmidt, Lisette Okkels Jensen, Christian Hassager, Hanne Berg Ravn and Jacob E. Møller

A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis

Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies ...

Authors: Jane Fisher, Chiara Pavan, Luisa S. Ohlmeier, Bo Nilson, Iben Lundgaard, Adam Linder and Peter Bentzer

CytoSorb removes MDMA in vitro, but is it an effective therapy in vivo?

3,4-Methylenedioxymethamphetamine intoxication can result in potentially lethal multi-organ failure, for which the current treatment is largely supportive. Recently, a report of the use of the CytoSorb device ...

Authors: Patrick M. Honore, Sebastien Redant and Thomas Datzmann

The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation

Positive end-expiratory pressure (PEEP) is used to optimize oxygenation by preventing alveolar collapse. However, PEEP can potentially decrease cardiac output through cardiopulmonary interactions. The effect o...

Authors: Yosef Levenbrown, Md Jobayer Hossain, James P. Keith, Katlyn Burr, Anne Hesek and Thomas Shaffer

ECMO cannula-associated infections: interest of cannula swab and subcutaneous needle aspirate samples for prediction of cannula tip culture

Authors: Hadrien Winiszewski, Charles Boyadjian, Guillaume Besch, Andrea Perrotti and Gaël Piton

Effects of intensive care unit ambient sounds on healthcare professionals: results of an online survey and noise exposure in an experimental setting

Noise levels on intensive care units (ICUs) are typically elevated. While many studies reported negative effects of ICU ambient sounds on patients, only few investigated noise as a factor to influence well-bei...

Authors: Nadine Schmidt, Stephan M. Gerber, Björn Zante, Tom Gawliczek, Alvin Chesham, Klemens Gutbrod, René M. Müri, Tobias Nef, Joerg C. Schefold and Marie-Madlen Jeitziner

The surviving sepsis campaign: basic/translational science research priorities

Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.

Authors: Clifford S. Deutschman, Judith Hellman, Ricard Ferrer Roca, Daniel De Backer and Craig M. Coopersmith

Correction to: Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients

An amendment to this paper has been published and can be accessed via the original article.

Authors: Emma M. Chang, Andrew Bretherick, Gordon B. Drummond and J. Kenneth Baillie

Water content of the endothelial glycocalyx layer estimated by volume kinetic analysis

The water volume of the endothelial glycocalyx layer has been estimated at 0.7 to 1.7 L using tracer methods of unclear value. The present study attempts to measure this fluid volume by analyzing the kinetics ...

Authors: Robert G. Hahn

Letter to the Editor: regarding “Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients”

Authors: Philip J. Peyton and Luke R. Fletcher

Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation

Primary blast lung injury (PBLI) presents as a syndrome of respiratory distress and haemoptysis resulting from explosive shock wave exposure and is a frequent cause of mortality and morbidity in both military ...

Authors: Timothy E. Scott, Anup Das, Mainul Haque, Declan G. Bates and Jonathan G. Hardman

Plasma-Lyte 148 and Plasma-Lyte 148 + 5% glucose compatibility with commonly used critical care drugs

Plasma-Lyte is a balanced, crystalloid intravenous fluid which has been shown to avoid the hyperchloremic metabolic acidosis associated with 0.9% sodium chloride. Data on physical, pH and chemical compatibilit...

Authors: Sophie Hammond, Andrew Wignell, Paul Cooling, David A. Barrett and Patrick Davies

Use of the CytoSorb adsorption device in MDMA intoxication: a first-in-man application and in vitro study

3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) abuse is frequent, and overdosing might cause severe and eventually lethal multi-organ failure. To date, there is no causal therapy of MDMA intoxication and ...

Authors: Corinna N. Lang, Michaela J. Sommer, Merja A. Neukamm, Dawid L. Staudacher, Alexander Supady, Christoph Bode, Daniel Duerschmied and Achim Lother

Analysis of blood culture in a rat model of cecal ligation and puncture induced sepsis

Authors: Prabakar Vaittinada Ayar, Hervé Jacquier, Benjamin Deniau, Feriel Azibani, Alexandre Mebazaa and Alice Blet

The importance of discovery science in the development of therapies for the critically ill

Discovery science, a term which encompasses basic, translational, and computational science with the aim to discover new therapies, has advanced critical care. By combining knowledge on inflammatory and genomi...

Authors: Nicole P. Juffermans, Peter Radermacher and John G. Laffey

Heart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used to treat patients with refractory severe heart failure. Large animal models are developed to help understand physiology an...

Authors: Silver Heinsar, Sacha Rozencwajg, Jacky Suen, Gianluigi Li Bassi, Maximilian Malfertheiner, Leen Vercaemst, Lars Mikael Broman, Matthieu Schmidt, Alain Combes, Indrek Rätsep, John F. Fraser and Jonathan E. Millar

Method of respiratory rate measurement using a unique wearable platform and an adaptive optical-based approach

An efficient and accurate method of respiratory rate measurement is still missing in hospital general wards and triage. The goal of this study is to propose a method of respiratory rate measurement that has a ...

Authors: Gurpreet Singh, Augustine Tee, Thanawin Trakoolwilaiwan, Aza Taha and Malini Olivo

In vitro characterization of PrismaLung+: a novel ECCO₂R device

Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal CO₂ removal (ECCO₂R) technologies may fac...

Authors: Ingeborg Hospach, Jacques Goldstein, Kai Harenski, John G. Laffey, Dominique Pouchoulin, Manuela Raible, Stefanie Votteler and Markus Storr

Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke

Several therapeutic strategies to rescue the brain from ischemic injury have improved outcomes after stroke; however, there is no treatment as yet for reperfusion injury, the secondary damage caused by necessa...

Authors: Bruna Pescador Mendonça, Juliano Dos Santos Cardoso, Monique Michels, Ana Carolina Vieira, Diogo Wendhausen, Andressa Manfredini, Mervyn Singer, Felipe Dal-Pizzol and Alex Dyson

New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma

Patients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these i...

Authors: Lillian Hesselink, Roy Spijkerman, Emma de Fraiture, Suzanne Bongers, Karlijn J. P. Van Wessem, Nienke Vrisekoop, Leo Koenderman, Luke P. H. Leenen and Falco Hietbrink

Update of the organoprotective properties of xenon and argon: from bench to beside

The growth of the elderly population has led to an increase in patients with myocardial infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111–115, 2019). Patients receiving treatment for ST-segment-...

Authors: Roehl Anna, Rossaint Rolf and Coburn Mark

Real-time effects of PEEP and tidal volume on regional ventilation and perfusion in experimental lung injury

Real-time bedside information on regional ventilation and perfusion during mechanical ventilation (MV) may help to elucidate the physiological and pathophysiological effects of MV settings in healthy and injur...

Authors: João Batista Borges, John N. Cronin, Douglas C. Crockett, Göran Hedenstierna, Anders Larsson and Federico Formenti

Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury

Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) resul...

Authors: Xiaoyan Wen, Shengnan Li, Alicia Frank, Xiukai Chen, David Emlet, Neil A. Hukriede and John A. Kellum

Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism

Human mesenchymal stem/stromal cells (hMSCs) represent a promising therapeutic strategy for ventilator-induced lung injury (VILI) and acute respiratory distress syndrome. Translational challenges include resto...

Authors: Shahd Horie, Sean Gaynard, Mary Murphy, Frank Barry, Michael Scully, Daniel O’Toole and John G. Laffey

Checkpoint inhibitor therapy in preclinical sepsis models: a systematic review and meta-analysis

Animal studies reporting immune checkpoint inhibitors (CPIs) improved host defense and survival during bacterial sepsis provided one basis for phase I CPI sepsis trials. We performed a systematic review and me...

Authors: Lindsay M. Busch, Junfeng Sun, Xizhong Cui, Peter Q. Eichacker and Parizad Torabi-Parizi

In vitro comparison between inspiration synchronized and continuous vibrating mesh nebulizer during trans-nasal aerosol delivery

Compared to continuous vibrating mesh nebulizer (VMN), inspiration synchronized VMN has shown increased inhaled dose during noninvasive ventilation; however, its use during aerosol delivery via high-flow nasal...

Authors: Jie Li, Wei Wu and James B. Fink

Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness

Hydrogen sulfide (H₂S) has long been known as a toxic environmental hazard. Discovery of physiological roles of H₂S as a neurotransmitter by Kimura and colleagues triggered an intensive research in the biological...

Authors: Eizo Marutani and Fumito Ichinose

Correction to: A case of intracoronary and endovenous levosimendan as a rescue therapy for refractory cardiac arrest

After publication of this supplement [1], it was brought to our attention that the author ‘L. Vegnuti’ has been erroneously omitted from the author list of the following abstract.

Authors: B. Ferro, R. Tofani, L. Vegnuti, G. Borelli, L. Gargani and P. Roncucci

Meta-analysis of targeted temperature management in animal models of cardiac arrest

Targeted temperature management (TTM) of 32 to 34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 indicated benefit on survival and neurological outcome. In ...

Authors: Hilmer Olai, Gustav Thornéus, Hannah Watson, Malcolm Macleod, Jonathan Rhodes, Hans Friberg, Niklas Nielsen, Tobias Cronberg and Tomas Deierborg

Carbon monoxide in intensive care medicine—time to start the therapeutic application?!

Carbon monoxide (CO) is not only known as a toxic gas due to its characteristics as an odorless molecule and its rapid binding to haem-containing molecules, thus inhibiting the respiratory chain in cells resul...

Authors: Ulrich Goebel and Jakob Wollborn

Aortic volume determines global end-diastolic volume measured by transpulmonary thermodilution

Global end-diastolic volume (GEDV) measured by transpulmonary thermodilution is regarded as indicator of cardiac preload. A bolus of cold saline injected in a central vein travels through the heart and lung, b...

Authors: Aleksej Akohov, Christoph Barner, Steffen Grimmer, Roland CE Francis and Stefan Wolf

Intracellular calcium signaling and phospho-antigen measurements reveal functional proximal TCR activation in lymphocytes from septic shock patients

Authors: Charles de Roquetaillade, Khalil Kandara, Morgane Gossez, Estelle Peronnet, Céline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret and Fabienne Venet

Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons

Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble...

Authors: Nina C. Weber and Benedikt Preckel

Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model

Improvement of single site cannulation for extracorporeal membrane oxygenation (ECMO) therapy is pivotal for reduction of patient morbidity and mortality in respiratory failure. To further improve the cardiopu...

Authors: Ruslan Natanov, Abdurasul Khalikov, Faikah Gueler, Ulrich Maus, Erin C. Boyle, Axel Haverich, Christian Kühn and Nodir Madrahimov