Skip to main content

Articles

Page 1 of 35

  1. Acute respiratory distress syndrome (ARDS) is a form of respiratory failure stemming from various underlying conditions that ultimately lead to inflammation and lung fibrosis. Bromodomain and Extra-Terminal mo...

    Authors: Manuela Iten, Camille Gschwend, Alessandro Ostini, David Robert Cameron, Christine Goepfert, David Berger and Matthias Haenggi
    Citation: Intensive Care Medicine Experimental 2024 12:19
  2. Several studies have demonstrated associations between greater rate/volume of intravenous (IV) fluid administration and poorer clinical outcomes. One postulated mechanism for harm from exogenous fluids is shed...

    Authors: Sara Sukudom, Lisa Smart and Stephen Macdonald
    Citation: Intensive Care Medicine Experimental 2024 12:16
  3. Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the “obesity paradox...

    Authors: Mikaela Eng, Keshikaa Suthaaharan, Logan Newton, Fatima Sheikh and Alison Fox-Robichaud
    Citation: Intensive Care Medicine Experimental 2024 12:15
  4. Authors: Raghavan Murugan, Kianoush Kashani and Paul M. Palevsky
    Citation: Intensive Care Medicine Experimental 2024 12:17

    The original article was published in Intensive Care Medicine Experimental 2024 12:18

    The Correspondence to this article has been published in Intensive Care Medicine Experimental 2024 12:18

  5. ECPELLA, a combination of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) and Impella, a percutaneous left ventricular (LV) assist device, has emerged as a novel therapeutic option in patients wi...

    Authors: Hiroki Matsushita, Keita Saku, Takuya Nishikawa, Shohei Yokota, Kei Sato, Hidetaka Morita, Yuki Yoshida, Masafumi Fukumitsu, Kazunori Uemura, Toru Kawada and Ken Yamaura
    Citation: Intensive Care Medicine Experimental 2024 12:13
  6. Exhaled volatile organic compounds (VOCs), particularly hydrocarbons from oxidative stress-induced lipid peroxidation, are associated with hyperoxia exposure. However, important heterogeneity amongst identifie...

    Authors: Thijs A. Lilien, Dominic W. Fenn, Paul Brinkman, Laura A. Hagens, Marry R. Smit, Nanon F. L. Heijnen, Job B. M. van Woensel, Lieuwe D. J. Bos and Reinout A. Bem
    Citation: Intensive Care Medicine Experimental 2024 12:14
  7. How assisted spontaneous breathing should be used during acute respiratory distress syndrome is questioned. Recent evidence suggests that high positive end-expiratory pressure (PEEP) may limit the risk of pati...

    Authors: Hannes Widing, Mariangela Pellegrini, Elena Chiodaroli, Per Persson, Katarina Hallén and Gaetano Perchiazzi
    Citation: Intensive Care Medicine Experimental 2024 12:10
  8. Continuous renal replacement therapy (CRRT) support is crucial for critically ill patients and it is underexplored in specific situations. Experimental CRRT offers a means to gain insights into these scenarios...

    Authors: Yuri de Albuquerque Pessoa dos Santos, Viviane Flor Park, Luis Carlos Maia Cardozo Junior, Bruno Adler Maccagnan Pinheiro Besen, Pedro Vitale Mendes and Marcelo Park
    Citation: Intensive Care Medicine Experimental 2024 12:9
  9. The models used to investigate the pathophysiological mechanisms of acute critical illness are not limited to mammalian species. The zebrafish (Danio rerio) is a popular model organism for studying diseases due t...

    Authors: Kensuke Fujii, Kazuma Yamakawa, Yuriko Takeda, Natsuko Okuda, Akira Takasu and Fumihito Ono
    Citation: Intensive Care Medicine Experimental 2024 12:8
  10. Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair and vascular endothelial-protect...

    Authors: Tomotaka Miura, Tomoki Okuda, Kodai Suzuki, Hideshi Okada, Hiroyuki Tomita, Chihiro Takada, Kosuke Mori, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Yohei Fukuda, Hirotsugu Fukuda, Ayane Nishio, Yuki Kawasaki, Ayumi Kuroda, Keiko Suzuki…
    Citation: Intensive Care Medicine Experimental 2024 12:7
  11. Lung weight is an important study endpoint to assess lung edema in porcine experiments on acute respiratory distress syndrome and ventilatory induced lung injury. Evidence on the relationship between lung–body...

    Authors: Antonio Fioccola, Rosmery Valentina Nicolardi, Tommaso Pozzi, Isabella Fratti, Federica Romitti, Francesca Collino, Verena Reupke, Gianluigi Li Bassi, Alessandro Protti, Alessandro Santini, Massimo Cressoni, Mattia Busana, Onnen Moerer, Luigi Camporota and Luciano Gattinoni
    Citation: Intensive Care Medicine Experimental 2024 12:6
  12. Respiratory quotient (RQ) is an important variable when assessing metabolic status in intensive care patients. However, analysis of RQ requires cumbersome technical equipment. The aim of the current study was ...

    Authors: Jacob Karlsson, Anders Svedmyr, Mats Wallin, Magnus Hallbäck and Per-Arne Lönnqvist
    Citation: Intensive Care Medicine Experimental 2024 12:11
  13. Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis a...

    Authors: Klaus Stahl, Christian Bode, Benjamin Seeliger, Pedro David Wendel-Garcia and Sascha David
    Citation: Intensive Care Medicine Experimental 2024 12:5
  14. We have previously reported a simple correction method for estimating pleural pressure (Ppl) using central venous pressure (CVP). However, it remains unclear whether this method is applicable to patients with ...

    Authors: Miyako Kyogoku, Soichi Mizuguchi, Taku Miyasho, Yusuke Endo, Yu Inata, Kazuya Tachibana, Yuji Fujino, Kazuto Yamashita and Muneyuki Takeuchi
    Citation: Intensive Care Medicine Experimental 2024 12:4
  15. Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney,...

    Authors: Regina Sordi, Luana Bojko, Filipe R. M. B. Oliveira, Thiele Osvaldt Rosales, Camila Fernandes Souza, Lucas Wenceslau Moreno, Gustavo Ferreira Alves, José Carlos Rebuglio Vellosa, Daniel Fernandes and Jose Rosa Gomes
    Citation: Intensive Care Medicine Experimental 2024 12:2
  16. Acute brain injuries, such as traumatic brain injury and ischemic and hemorragic stroke, are a leading cause of death and disability worldwide. While characterized by clearly distict primary events—vascular da...

    Authors: Chiara Robba, Elisa R. Zanier, Carmen Lopez Soto, Soojin Park, Romain Sonneville, Raimund Helbolk, Aarti Sarwal, Virginia F. J. Newcombe, Mathieu van der Jagt, Jan Gunst, Tobias Gauss, Samy Figueiredo, Jacques Duranteau, Markus B. Skrifvars, Carolina Iaquaniello, Susanne Muehlschlegel…
    Citation: Intensive Care Medicine Experimental 2024 12:1
  17. Clogging is characterized by a progressive impairment of transmembrane patency in renal replacement devices and occurs due to obstruction of pores by unknown molecules. If citrate-based anti-coagulation is use...

    Authors: Mattia M. Müller, Larina Caspar, Onur Sazpinar, Daniel A. Hofmaenner, Rolf Erlebach, Rea Andermatt, Christoph C. Ganter, Reto A. Schuepbach, Pedro D. Wendel-Garcia and Sascha David
    Citation: Intensive Care Medicine Experimental 2023 11:99
  18. Mechanical power may serve as a valuable parameter for predicting ventilation-induced injury in mechanically ventilated patients. Over time, several equations have been developed to calculate power in both vol...

    Authors: Özlem Acicbe, Canan Yazıcı Özgür, Payam Rahimi, Emral Canan, Sinan Aşar and Zafer Çukurova
    Citation: Intensive Care Medicine Experimental 2023 11:98
  19. Acute kidney injury (AKI) is frequent among critically ill patients. Renal replacement therapy (RRT) is often required to deal with severe complications of AKI. This technique is however associated with side e...

    Authors: J. Mallet, P.-A. Billiet, M. Scarton, N. Benichou, M. Bobot, K. Chaibi, A. Hertig, J. Hadchouel, D. Dreyfuss, S. Gaudry and S. Placier
    Citation: Intensive Care Medicine Experimental 2023 11:97
  20. Capillary leak syndrome (CLS) represents a phenotype of increased fluid extravasation, resulting in intravascular hypovolemia, extravascular edema formation and ultimately hypoperfusion. While endothelial perm...

    Authors: Babak Saravi, Ulrich Goebel, Lars O. Hassenzahl, Christian Jung, Sascha David, Aarne Feldheiser, Matthias Stopfkuchen-Evans and Jakob Wollborn
    Citation: Intensive Care Medicine Experimental 2023 11:96
  21. Side effects of mechanical ventilation, such as ventilator-induced diaphragmatic dysfunction (VIDD) and ventilator-induced lung injury (VILI), occur frequently in critically ill patients. Phrenic nerve stimula...

    Authors: Alessandro Panelli, Michael A. Verfuß, Martin Dres, Laurent Brochard and Stefan J. Schaller
    Citation: Intensive Care Medicine Experimental 2023 11:94
  22. We aimed to evaluate the pulmonary and cerebral effects of low-tidal volume ventilation in pressure-support (PSV) and pressure-controlled (PCV) modes at two PEEP levels in acute ischemic stroke (AIS).

    Authors: Adriana L. da Silva, Camila M. Bessa, Nazareth N. Rocha, Eduardo B. Carvalho, Raquel F. Magalhaes, Vera L. Capelozzi, Chiara Robba, Paolo Pelosi, Cynthia S. Samary, Patricia R. M. Rocco and Pedro L. Silva
    Citation: Intensive Care Medicine Experimental 2023 11:93
  23. Optimal cerebral perfusion pressure (CPPopt) has emerged as a promising personalized medicine approach to the management of moderate-to-severe traumatic brain injury (TBI). Though literature demonstrating its ...

    Authors: Kevin Y. Stein, Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Younis Ibrahim, Abrar Islam, Izabella Marquez, Fiorella Amenta, Tobias Bergmann and Frederick A. Zeiler
    Citation: Intensive Care Medicine Experimental 2023 11:92
  24. Limb ischemia or compartment syndrome, requiring surgery, are some of the frequent cannula-related complications in patients supported with veno-arterial extracorporeal membrane oxygenation (VA-ECMO). The purp...

    Authors: Mariya Maslarska, Sven Piepenburg, Dirk Westermann, Alexander Supady and Christoph Hehrlein
    Citation: Intensive Care Medicine Experimental 2023 11:91
  25. Recent data from the randomized SUSTAIN CSX trial could not confirm clinical benefits from perioperative selenium treatment in high-risk cardiac surgery patients. Underlying reasons may involve inadequate bios...

    Authors: Quirin Notz, Daren K. Heyland, Zheng-Yii Lee, Johannes Menger, Johannes Herrmann, Thilo S. Chillon, Stephen Fremes, Siamak Mohammadi, Gunnar Elke, C. David Mazer, Aileen Hill, Markus Velten, Sascha Ott, Maren Kleine-Brueggeney, Patrick Meybohm, Lutz Schomburg…
    Citation: Intensive Care Medicine Experimental 2023 11:89
  26. Direct assessment of microcirculatory function remains a critical care research tool but approaches for analysis of microcirculatory videomicroscopy clips are shifting from manual to automated algorithms, with...

    Authors: Raushan C. B. Lala, Ryan A. P. Homes, Jeffrey Lipman and Mark J. Midwinter
    Citation: Intensive Care Medicine Experimental 2023 11:88
  27. Extracellular vesicles (EVs) represent nanometer-sized, subcellular spheres, that are released from almost any cell type and carry a wide variety of biologically relevant cargo. In severe cases of coronavirus ...

    Authors: Johannes Zipperle, Johannes Oesterreicher, Matthias Hackl, Teresa Lara Krammer, Helena Thumfart, Madhusudhan Reddy Bobbili, Marion Wiegele, Johannes Grillari, Marcin F. Osuchowski, Herbert Schöchl, Wolfgang Holnthoner, Christoph J. Schlimp, Judith Schiefer, Marco Valerio Pesce, Stefan Ulbing and Johannes Gratz
    Citation: Intensive Care Medicine Experimental 2023 11:85
  28. Critical illness is characterized by a hypercatabolic response encompassing endocrine and metabolic alterations. Not only the uptake, synthesis and metabolism of glucose and amino acids is majorly affected, bu...

    Authors: Caroline Lauwers, Lauren De Bruyn and Lies Langouche
    Citation: Intensive Care Medicine Experimental 2023 11:84
  29. Mechanical ventilation is a life-saving therapy in several clinical situations, promoting gas exchange and providing rest to the respiratory muscles. However, mechanical ventilation may cause hemodynamic insta...

    Authors: Pedro Leme Silva, Martin Scharffenberg and Patricia Rieken Macedo Rocco
    Citation: Intensive Care Medicine Experimental 2023 11:82
  30. This study aimed to determine whether ultra-low tidal volume ventilation (ULTVV) applied during cardiopulmonary resuscitation (CPR) compared with standard ventilation (intermittent positive pressure ventilatio...

    Authors: Katja Mohnke, Philipp Conzelmann, Miriam Renz, Julian Riedel, René Rissel, Andrea Urmann, Johanna Hain, Bastian Duenges, Alexander Ziebart and Robert Ruemmler
    Citation: Intensive Care Medicine Experimental 2023 11:81
  31. Venous blood gas sampling has replaced arterial sampling in many critically ill patients, though interpretation of venous pCO2 still remains a challenge. Lemoël et al., Farkas and Zeserson et al. have proposed mo...

    Authors: Matthias Jörg, Malin Öster, Jens Wretborn and Daniel B. Wilhelms
    Citation: Intensive Care Medicine Experimental 2023 11:80
  32. Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some...

    Authors: Tianfeng Hua, Yuqian Chu, Minjie Wang, Yijun Zhang, Wei Shi, Qihui Huang, Liangliang Zhang and Min Yang
    Citation: Intensive Care Medicine Experimental 2023 11:78
  33. Extracorporeal life support (ECLS) for acute respiratory failure encompasses veno-venous extracorporeal membrane oxygenation (V-V ECMO) and extracorporeal carbon dioxide removal (ECCO2R). V-V ECMO is primarily us...

    Authors: Tommaso Tonetti, Alberto Zanella, David Pérez-Torres, Giacomo Grasselli and V. Marco Ranieri
    Citation: Intensive Care Medicine Experimental 2023 11:77
  34. Trauma patients frequently receive supplemental oxygen, but its hemodynamic effects in blood loss are poorly understood. We studied the effects of oxygen on the hemodynamic response and tolerance to simulated ...

    Authors: Sole Lindvåg Lie, Jonny Hisdal, Marius Rehn and Lars Øivind Høiseth
    Citation: Intensive Care Medicine Experimental 2023 11:76
  35. Ventilation during cardiopulmonary resuscitation (CPR) has long been a part of the standard treatment during cardiac arrests. Ventilation is usually given either during continuous chest compressions (CCC) or d...

    Authors: Johan Mälberg, Silvia Marchesi, Douglas Spangler, Nermin Hadziosmanovic, David Smekal and Sten Rubertsson
    Citation: Intensive Care Medicine Experimental 2023 11:75
  36. There is a need to monitor tidal volume in critically ill patients with acute respiratory failure, given its relation with adverse clinical outcome. However, quantification of tidal volume in non-intubated pat...

    Authors: Matthijs L. Janssen, Annemijn H. Jonkman, Myrte Wennen, Evert-Jan Wils, Henrik Endeman and Leo Heunks
    Citation: Intensive Care Medicine Experimental 2023 11:73
  37. Neurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus clearance. Detailed understanding of the underlying changes in brain functio...

    Authors: Salil R. Rajayer and Stephen M. Smith
    Citation: Intensive Care Medicine Experimental 2023 11:71
  38. Sepsis is characterized by highly heterogeneous immune responses associated with a spectrum of disease severity. Methods that rapidly and sensitively profile these immune responses can potentially personalize ...

    Authors: Anthony S. Bonavia, Abigail Samuelsen, Menglu Liang, Jodi Hanson, Daniel McKeone, Zissis C. Chroneos and E. Scott Halstead
    Citation: Intensive Care Medicine Experimental 2023 11:70
  39. A prompt and effective immune response is required for clearance of pathogens but exaggerated states of inflammation can cause extensive collateral damage to the host. We have previously used a rapid near-pati...

    Authors: Nazlıhan Boyacı Dündar, David Sarphie, Kenan Yüce, Ümmügülsüm Gaygısız, O. Tolga Kaskatı, Melda Türkoğlu, Gülbin Aygencel Bıkmaz, Lale Karabıyık, Kayhan Çağlar, Gülendam Bozdayı, Rubina Mian, Paul Moss and Mustafa Necmi İlhan
    Citation: Intensive Care Medicine Experimental 2023 11:69