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  1. The human gastrointestinal tract harbours a complex multi-kingdom community known as the microbiome. Dysbiosis refers to its disruption and is reportedly extreme in acute critical illness yet its clinical implica...

    Authors: Tess Evans, Umar Ali, Ryan Anderton, Edward Raby, Laurens Manning and Edward Litton
    Citation: Intensive Care Medicine Experimental 2023 11:6
  2. To date cardiac arrest (CA) remains a frequent cause of morbidity and mortality: despite advances in cardiopulmonary resuscitation (CPR), survival is still burdened by hypoxic–ischemic brain injury (HIBI), and...

    Authors: Elisabetta Roberti, Giovanni Chiarini, Nicola Latronico, Enrica Chiara Adami, Chiara Plotti, Elisa Bonetta, Federica Magri and Frank Anthony Rasulo
    Citation: Intensive Care Medicine Experimental 2023 11:4
  3. Atrial fibrillation (AF) is the most common cardiac arrhythmia in the intensive care unit and is associated with increased morbidity and mortality. New-onset atrial fibrillation (NOAF) is often initially parox...

    Authors: Brian Chen, David M. Maslove, Jeffrey D. Curran, Alexander Hamilton, Philip R. Laird, Parvin Mousavi and Stephanie Sibley
    Citation: Intensive Care Medicine Experimental 2023 11:2
  4. In refractory out-of-hospital cardiac arrest, transportation to hospital with continuous chest compressions (CCC) from a chest compression device and ventilation with 100% oxygen through an advanced airway is ...

    Authors: Jukka Kopra, Erik Litonius, Pirkka T. Pekkarinen, Merja Laitinen, Juho A. Heinonen, Luca Fontanelli, Tomi P. Mäkiaho and Markus B. Skrifvars
    Citation: Intensive Care Medicine Experimental 2023 11:3
  5. Hyper-inflammatory syndrome in children and young adult occur 2–6 weeks after COVID-19 infection or closed contact with COVID-19 persons. In this study, the laboratory data and echocardiography and abdominal u...

    Authors: Payman Sadeghi, Mojtaba Gorji, Raheleh Assari, Fatemeh Tahghighi, Seyed Reza Raeeskarami and Vahid Ziaee
    Citation: Intensive Care Medicine Experimental 2022 10:56
  6. Brain tissue oxygen tension (PbtO2) and cerebrovascular pressure reactivity monitoring have emerged as potential modalities to individualize care in moderate and severe traumatic brain injury (TBI). The relations...

    Authors: Alwyn Gomez, Mypinder Sekhon, Donald Griesdale, Logan Froese, Eleen Yang, Eric P. Thelin, Rahul Raj, Marcel Aries, Clare Gallagher, Francis Bernard, Andreas H. Kramer and Frederick A. Zeiler
    Citation: Intensive Care Medicine Experimental 2022 10:54
  7. Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combi...

    Authors: Denise Battaglini, Adriana Lopes da Silva, Nathane Santanna Felix, Gisele Rodrigues, Mariana Alves Antunes, Nazareth Novaes Rocha, Vera Luiza Capelozzi, Marcelo Marcos Morales, Fernanda Ferreira Cruz, Chiara Robba, Pedro Leme Silva, Paolo Pelosi and Patricia Rieken Macedo Rocco
    Citation: Intensive Care Medicine Experimental 2022 10:53
  8. Continuous measurement of urinary PO2 (PuO2) is being applied to indirectly monitor renal medullary PO2. However, when applied to critically ill patients with shock, its measurement may be affected by changes in ...

    Authors: Eduardo A. Osawa, Salvatore L. Cutuli, Fumitaka Yanase, Naoya Iguchi, Laurent Bitker, Alexandre T. Maciel, Yugeesh R. Lankadeva, Clive N. May, Roger G. Evans, Glenn M. Eastwood and Rinaldo Bellomo
    Citation: Intensive Care Medicine Experimental 2022 10:52
  9. Fluid resuscitation is crucial in the initial management of sepsis; however, little is known about the serial changes and overall distribution of fluids administered into the body. To identify the feasibility ...

    Authors: Hwain Jeong, Inwon Park, Jae Hyuk Lee, Dongsung Kim, Sumin Baek, Seonghye Kim and You Hwan Jo
    Citation: Intensive Care Medicine Experimental 2022 10:51
  10. This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

    Authors: Senta Jorinde Raasveld, Carolien Volleman, Alain Combes, Lars Mikael Broman, Fabio Silvio Taccone, Elma Peters, Sanne ten Berg, Charissa E. van den Brom, Holger Thiele, Roberto Lorusso, José P. S. Henriques and Alexander P. J. Vlaar
    Citation: Intensive Care Medicine Experimental 2022 10:50
  11. The gut has been hypothesized to be a protagonist tissue in multiple organ dysfunction syndrome (MODS) for the past three decades. Gastric reactance (XL) is a potential perfusion marker derived from gastric im...

    Authors: María M. Godinez-Garcia, Adrian Soto-Mota, Jorge Catrip, Ruben Gaitan, Ma del C. Lespron, Francisco J. Molina, Miguel A. Falcón, Alberto Aranda, Carlos A. Tena, Pedro Zamudio, Ivan Briseño, Rolando Alvarez and Yazmin Guillen
    Citation: Intensive Care Medicine Experimental 2022 10:49
  12. Authors: Francesca M. Stefanizzi, Lu Zhang, Antonio Salgado-Somoza, Josef Dankiewicz, Pascal Stammet, Christian Hassager, Matthew P. Wise, Hans Friberg, Tobias Cronberg, Alexander Hundt, Jesper Kjaergaard, Niklas Nielsen and Yvan Devaux
    Citation: Intensive Care Medicine Experimental 2022 10:48

    The original article was published in Intensive Care Medicine Experimental 2022 10:41

  13. Mitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional to the doses of noradrenaline, which patients are receiving. We compreh...

    Authors: Adéla Krajčová, Christine Skagen, Valér Džupa, Tomáš Urban, Arild C. Rustan, Kateřina Jiroutková, Bohumil Bakalář, G. Hege Thoresen and František Duška
    Citation: Intensive Care Medicine Experimental 2022 10:47
  14. Fluid administration is a cornerstone of treatment of critically ill patients. The aim of this review is to reappraise the pathophysiology of fluid therapy, considering the mechanisms related to the interplay ...

    Authors: Antonio Messina, Jan Bakker, Michelle Chew, Daniel De Backer, Olfa Hamzaoui, Glenn Hernandez, Sheila Nainan Myatra, Xavier Monnet, Marlies Ostermann, Michael Pinsky, Jean-Louis Teboul and Maurizio Cecconi
    Citation: Intensive Care Medicine Experimental 2022 10:46
  15. Cardiac arrest (CA) represents the third leading cause of death worldwide. Among patients resuscitated and admitted to hospital, death and severe neurological sequelae are frequent but difficult to predict. Bl...

    Authors: Francesca M. Stefanizzi, Lu Zhang, Antonio Salgado-Somoza, Josef Dankiewicz, Pascal Stammet, Christian Hassager, Matthew P. Wise, Hans Friberg, Tobias Cronberg, Alexander Hundt, Jesper Kjaergaard, Niklas Nielsen and Yvan Devaux
    Citation: Intensive Care Medicine Experimental 2022 10:41

    The Correction to this article has been published in Intensive Care Medicine Experimental 2022 10:48

  16. Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled ca...

    Authors: Lauge Vammen, Cecilie Munch Johannsen, Andreas Magnussen, Amalie Povlsen, Søren Riis Petersen, Arezo Azizi, Michael Pedersen, Anders Rosendal Korshøj, Steffen Ringgaard, Bo Løfgren, Lars W. Andersen and Asger Granfeldt
    Citation: Intensive Care Medicine Experimental 2022 10:45
  17. Severe inflammatory diseases, including sepsis, are characterized by an impaired host adaptive and innate immunity which results in immunosuppression, responsible for secondary infections and increased morbidi...

    Authors: Marta Luperto and Lara Zafrani
    Citation: Intensive Care Medicine Experimental 2022 10:43
  18. Timely identification of deteriorating COVID-19 patients is needed to guide changes in clinical management and admission to intensive care units (ICUs). There is significant concern that widely used Early warn...

    Authors: Jim M. Smit, Jesse H. Krijthe, Andrei N. Tintu, Henrik Endeman, Jeroen Ludikhuize, Michel E. van Genderen, Shermarke Hassan, Rachida El Moussaoui, Peter E. Westerweel, Robbert J. Goekoop, Geeke Waverijn, Tim Verheijen, Jan G. den Hollander, Mark G. J. de Boer, Diederik A. M. P. J. Gommers, Robin van der Vlies…
    Citation: Intensive Care Medicine Experimental 2022 10:38
  19. The optimal hemodynamic targets and management of patients with acute brain injury are not completely elucidated, but recent evidence points to important impact on clinical outcomes. We performed an internatio...

    Authors: Antonio Messina, Federico Villa, Giulia Lionetti, Laura Galarza, Geert Meyfroidt, Mathieu van der Jagt, Xavier Monnet, Paolo Pelosi, Maurizio Cecconi and Chiara Robba
    Citation: Intensive Care Medicine Experimental 2022 10:42
  20. Acute respiratory distress syndrome (ARDS) is a common disease in intensive care medicine. Despite intensive research, mortality rates are high, not even in COVID-19 ARDS. Thereby, pigs offer some advantages t...

    Authors: René Rissel, Miriam Renz, Katja Mohnke, Julian Riedel, Katharina Ritter, Alexander Ziebart, Robert Ruemmler, Erik K. Hartmann and Jens Kamuf
    Citation: Intensive Care Medicine Experimental 2022 10:37
  21. Hyperchloremic metabolic acidosis that develops during the treatment of diabetic ketoacidosis is usually attributed to the chloride content of resuscitation fluids. We explored an alternative explanation, name...

    Authors: Robert Svensson, Robert G. Hahn, Joachim H. Zdolsek and Hans Bahlmann
    Citation: Intensive Care Medicine Experimental 2022 10:36
  22. ICU survivors suffer from impaired physical function and reduced exercise capacity, yet the underlying mechanisms are poorly understood. The goal of this exploratory pilot study was to investigate potential me...

    Authors: Matthew F. Mart, E. Wesley Ely, James J. Tolle, Mayur B. Patel and Nathan E. Brummel
    Citation: Intensive Care Medicine Experimental 2022 10:35
  23. Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range of conditions including sepsis. Fresh frozen plasma (FFP) restores the damaged EG to baseline thickness, however the mech...

    Authors: Elissa M. Milford, Lara Meital, Anna Kuballa, Michael C. Reade and Fraser D. Russell
    Citation: Intensive Care Medicine Experimental 2022 10:34
  24. Impaired cerebral autoregulation has been linked with worse outcomes, with literature suggesting that current therapy guidelines fail to significantly impact cerebrovascular reactivity. The cerebral oximetry i...

    Authors: Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Carleen Batson, Trevor Slack, Kevin Y. Stein, Francois Mathieu and Frederick A. Zeiler
    Citation: Intensive Care Medicine Experimental 2022 10:33
  25. Models of hypoxemic lung injury caused by lavage-induced pulmonary surfactant depletion are prone to prompt recovery of blood oxygenation following recruitment maneuvers and have limited translational validity...

    Authors: Emilia Boerger, Martin Russ, Philip von Platen, Mahdi Taher, Lea Hinken, Anake Pomprapa, Rainer Koebrich, Frank Konietschke, Jan Adriaan Graw, Burkhard Lachmann, Wolfgang Braun, Steffen Leonhardt, Philipp A. Pickerodt and Roland C. E. Francis
    Citation: Intensive Care Medicine Experimental 2022 10:32
  26. Volume expansion and vasopressors for the treatment of shock is an intensive process that requires frequent assessments and adjustments. Strict blood pressure goals in multiple physiologic states of shock (tra...

    Authors: Nathan T. P. Patel, Eduardo J. Goenaga-Diaz, Magan R. Lane, M. Austin Johnson, Lucas P. Neff and Timothy K. Williams
    Citation: Intensive Care Medicine Experimental 2022 10:30
  27. Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the physiology of organ viability and in the pathophysiology of organ dysfunction, respectively. In this narrative review, we...

    Authors: Davide Signori, Aurora Magliocca, Kei Hayashida, Jan A. Graw, Rajeev Malhotra, Giacomo Bellani, Lorenzo Berra and Emanuele Rezoagli
    Citation: Intensive Care Medicine Experimental 2022 10:28
  28. Sex differences in sepsis are underexplored and incompletely understood. Cardiac function in early sepsis is pivotal in determining survival; hyperdynamic left ventricular ejection fraction is associated with ...

    Authors: Sophie L. M. Walker, Chand Muthoo, Jenifer Sanchez, Ana Gutierrez Del Arroyo and Gareth L. Ackland
    Citation: Intensive Care Medicine Experimental 2022 10:27
  29. Metabolic predictors and potential mediators of survival in sepsis have been incompletely characterized. We examined whether machine learning (ML) tools applied to the human plasma metabolome could consistentl...

    Authors: Leah B. Kosyakovsky, Emily Somerset, Angela J. Rogers, Michael Sklar, Jared R. Mayers, Augustin Toma, Yishay Szekely, Sabri Soussi, Bo Wang, Chun-Po S. Fan, Rebecca M. Baron and Patrick R. Lawler
    Citation: Intensive Care Medicine Experimental 2022 10:24
  30. Immune cell dysfunction plays a central role in sepsis-associated immune paralysis. The transfusion of healthy donor immune cells, i.e., granulocyte concentrates (GC) potentially induces tissue damage via loca...

    Authors: Gerd Klinkmann, Thomas Wild, Benjamin Heskamp, Fanny Doss, Sandra Doss, Lubomir Arseniev, Krasimira Aleksandrova, Martin Sauer, Daniel A. Reuter, Steffen Mitzner and Jens Altrichter
    Citation: Intensive Care Medicine Experimental 2022 10:26
  31. Frailty is common in critically ill patients and is associated with increased morbidity and mortality. There remains uncertainty as to the optimal method/timing of frailty assessment and the impact of care pro...

    Authors: John Muscedere, Sean M. Bagshaw, Gordon Boyd, Stephanie Sibley, Patrick Norman, Andrew Day, Miranda Hunt and Darryl Rolfson
    Citation: Intensive Care Medicine Experimental 2022 10:23

    The Correction to this article has been published in Intensive Care Medicine Experimental 2023 11:1

  32. Repeated expenditure of energy and its generation of damaging strain are required to injure the lung by ventilation (VILI). Mathematical modeling of passively inflated, single-compartment lungs with uniform pa...

    Authors: Philip S. Crooke, Luciano Gattinoni, Michael Michalik and John J. Marini
    Citation: Intensive Care Medicine Experimental 2022 10:21
  33. Mechanical power is a promising new metric to assess energy transfer from a mechanical ventilator to a patient, which combines the contributions of multiple parameters into a single comprehensive value. Howeve...

    Authors: Christine A. Trinkle, Richard N. Broaddus, Jamie L. Sturgill, Christopher M. Waters and Peter E. Morris
    Citation: Intensive Care Medicine Experimental 2022 10:22
  34. Flow-controlled ventilation (FCV), a novel mode of mechanical ventilation characterised by constant flow during active expiration, may result in more efficient alveolar gas exchange, better lung recruitment an...

    Authors: Eleni D. Van Dessel, Gregory R. De Meyer, Stuart G. Morrison, Philippe G. Jorens and Tom Schepens
    Citation: Intensive Care Medicine Experimental 2022 10:19
  35. Interventions, such as mechanical ventilation with high positive end-expiratory pressure (PEEP), increase inflammation in abdominal organs. This effect could be due to reduced venous return and impaired splanc...

    Authors: Silvia Marchesi, Anders Larsson, Göran Hedenstierna, Mohammed Abujazar, Håkan Ahlström and Miklós Lipcsey
    Citation: Intensive Care Medicine Experimental 2022 10:17
  36. Veno-venous extracorporeal membrane oxygenation (ECMO) provides blood oxygenation and carbon dioxide removal in acute respiratory distress syndrome. However, during ECMO support, the native lungs still play an...

    Authors: Pedro Vitale Mendes, Marcelo Park, Luciano Cesar Pontes de Azevedo, Caio Cesar Araujo Morais, Marcelo Brito Passos Amato and Eduardo Leite Vieira Costa
    Citation: Intensive Care Medicine Experimental 2022 10:15
  37. Sepsis is associated with substantial mortality rates. Antibiotic treatment is crucial, but global antibiotic resistance is now classified as one of the top ten global public health risks facing humanity. Ozon...

    Authors: Paul Skorup, Anette Fransson, Jenny Gustavsson, Johan Sjöholm, Henrik Rundgren, Volkan Özenci, Alicia Y. W. Wong, Tomas Karlsson, Christer Svensén and Mattias Günther
    Citation: Intensive Care Medicine Experimental 2022 10:14
  38. Mean circulatory filling pressure (Pmcf) provides information on stressed volume and is crucial for maintaining venous return. This study investigated the Pmcf and other determinants of venous return in dysrhy...

    Authors: Athanasios Chalkias, Eleni Laou, Nikolaos Papagiannakis, Giolanda Varvarousi, Dimitrios Ragias, Anastasios Koutsovasilis, Demosthenes Makris, Dimitrios Varvarousis, Nicoletta Iacovidou, Ioannis Pantazopoulos and Theodoros Xanthos
    Citation: Intensive Care Medicine Experimental 2022 10:13