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  1. Timely identification of deteriorating COVID-19 patients is needed to guide changes in clinical management and admission to intensive care units (ICUs). There is significant concern that widely used Early warn...

    Authors: Jim M. Smit, Jesse H. Krijthe, Andrei N. Tintu, Henrik Endeman, Jeroen Ludikhuize, Michel E. van Genderen, Shermarke Hassan, Rachida El Moussaoui, Peter E. Westerweel, Robbert J. Goekoop, Geeke Waverijn, Tim Verheijen, Jan G. den Hollander, Mark G. J. de Boer, Diederik A. M. P. J. Gommers, Robin van der Vlies…
    Citation: Intensive Care Medicine Experimental 2022 10:38
  2. Acute respiratory distress syndrome (ARDS) is a common disease in intensive care medicine. Despite intensive research, mortality rates are high, not even in COVID-19 ARDS. Thereby, pigs offer some advantages t...

    Authors: René Rissel, Miriam Renz, Katja Mohnke, Julian Riedel, Katharina Ritter, Alexander Ziebart, Robert Ruemmler, Erik K. Hartmann and Jens Kamuf
    Citation: Intensive Care Medicine Experimental 2022 10:37
  3. Hyperchloremic metabolic acidosis that develops during the treatment of diabetic ketoacidosis is usually attributed to the chloride content of resuscitation fluids. We explored an alternative explanation, name...

    Authors: Robert Svensson, Robert G. Hahn, Joachim H. Zdolsek and Hans Bahlmann
    Citation: Intensive Care Medicine Experimental 2022 10:36
  4. ICU survivors suffer from impaired physical function and reduced exercise capacity, yet the underlying mechanisms are poorly understood. The goal of this exploratory pilot study was to investigate potential me...

    Authors: Matthew F. Mart, E. Wesley Ely, James J. Tolle, Mayur B. Patel and Nathan E. Brummel
    Citation: Intensive Care Medicine Experimental 2022 10:35
  5. Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range of conditions including sepsis. Fresh frozen plasma (FFP) restores the damaged EG to baseline thickness, however the mech...

    Authors: Elissa M. Milford, Lara Meital, Anna Kuballa, Michael C. Reade and Fraser D. Russell
    Citation: Intensive Care Medicine Experimental 2022 10:34
  6. Impaired cerebral autoregulation has been linked with worse outcomes, with literature suggesting that current therapy guidelines fail to significantly impact cerebrovascular reactivity. The cerebral oximetry i...

    Authors: Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Carleen Batson, Trevor Slack, Kevin Y. Stein, Francois Mathieu and Frederick A. Zeiler
    Citation: Intensive Care Medicine Experimental 2022 10:33
  7. Models of hypoxemic lung injury caused by lavage-induced pulmonary surfactant depletion are prone to prompt recovery of blood oxygenation following recruitment maneuvers and have limited translational validity...

    Authors: Emilia Boerger, Martin Russ, Philip von Platen, Mahdi Taher, Lea Hinken, Anake Pomprapa, Rainer Koebrich, Frank Konietschke, Jan Adriaan Graw, Burkhard Lachmann, Wolfgang Braun, Steffen Leonhardt, Philipp A. Pickerodt and Roland C. E. Francis
    Citation: Intensive Care Medicine Experimental 2022 10:32
  8. Volume expansion and vasopressors for the treatment of shock is an intensive process that requires frequent assessments and adjustments. Strict blood pressure goals in multiple physiologic states of shock (tra...

    Authors: Nathan T. P. Patel, Eduardo J. Goenaga-Diaz, Magan R. Lane, M. Austin Johnson, Lucas P. Neff and Timothy K. Williams
    Citation: Intensive Care Medicine Experimental 2022 10:30
  9. Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the physiology of organ viability and in the pathophysiology of organ dysfunction, respectively. In this narrative review, we...

    Authors: Davide Signori, Aurora Magliocca, Kei Hayashida, Jan A. Graw, Rajeev Malhotra, Giacomo Bellani, Lorenzo Berra and Emanuele Rezoagli
    Citation: Intensive Care Medicine Experimental 2022 10:28
  10. Sex differences in sepsis are underexplored and incompletely understood. Cardiac function in early sepsis is pivotal in determining survival; hyperdynamic left ventricular ejection fraction is associated with ...

    Authors: Sophie L. M. Walker, Chand Muthoo, Jenifer Sanchez, Ana Gutierrez Del Arroyo and Gareth L. Ackland
    Citation: Intensive Care Medicine Experimental 2022 10:27
  11. Metabolic predictors and potential mediators of survival in sepsis have been incompletely characterized. We examined whether machine learning (ML) tools applied to the human plasma metabolome could consistentl...

    Authors: Leah B. Kosyakovsky, Emily Somerset, Angela J. Rogers, Michael Sklar, Jared R. Mayers, Augustin Toma, Yishay Szekely, Sabri Soussi, Bo Wang, Chun-Po S. Fan, Rebecca M. Baron and Patrick R. Lawler
    Citation: Intensive Care Medicine Experimental 2022 10:24
  12. Immune cell dysfunction plays a central role in sepsis-associated immune paralysis. The transfusion of healthy donor immune cells, i.e., granulocyte concentrates (GC) potentially induces tissue damage via loca...

    Authors: Gerd Klinkmann, Thomas Wild, Benjamin Heskamp, Fanny Doss, Sandra Doss, Lubomir Arseniev, Krasimira Aleksandrova, Martin Sauer, Daniel A. Reuter, Steffen Mitzner and Jens Altrichter
    Citation: Intensive Care Medicine Experimental 2022 10:26
  13. Frailty is common in critically ill patients and is associated with increased morbidity and mortality. There remains uncertainty as to the optimal method/timing of frailty assessment and the impact of care pro...

    Authors: John Muscedere, Sean M. Bagshaw, Gordon Boyd, Stephanie Sibley, Norman Patrick, Andrew Day, Miranda Hunt and Darryl Rolfson
    Citation: Intensive Care Medicine Experimental 2022 10:23
  14. Repeated expenditure of energy and its generation of damaging strain are required to injure the lung by ventilation (VILI). Mathematical modeling of passively inflated, single-compartment lungs with uniform pa...

    Authors: Philip S. Crooke, Luciano Gattinoni, Michael Michalik and John J. Marini
    Citation: Intensive Care Medicine Experimental 2022 10:21
  15. Mechanical power is a promising new metric to assess energy transfer from a mechanical ventilator to a patient, which combines the contributions of multiple parameters into a single comprehensive value. Howeve...

    Authors: Christine A. Trinkle, Richard N. Broaddus, Jamie L. Sturgill, Christopher M. Waters and Peter E. Morris
    Citation: Intensive Care Medicine Experimental 2022 10:22
  16. Flow-controlled ventilation (FCV), a novel mode of mechanical ventilation characterised by constant flow during active expiration, may result in more efficient alveolar gas exchange, better lung recruitment an...

    Authors: Eleni D. Van Dessel, Gregory R. De Meyer, Stuart G. Morrison, Philippe G. Jorens and Tom Schepens
    Citation: Intensive Care Medicine Experimental 2022 10:19
  17. Interventions, such as mechanical ventilation with high positive end-expiratory pressure (PEEP), increase inflammation in abdominal organs. This effect could be due to reduced venous return and impaired splanc...

    Authors: Silvia Marchesi, Anders Larsson, Göran Hedenstierna, Mohammed Abujazar, Håkan Ahlström and Miklós Lipcsey
    Citation: Intensive Care Medicine Experimental 2022 10:17
  18. Veno-venous extracorporeal membrane oxygenation (ECMO) provides blood oxygenation and carbon dioxide removal in acute respiratory distress syndrome. However, during ECMO support, the native lungs still play an...

    Authors: Pedro Vitale Mendes, Marcelo Park, Luciano Cesar Pontes de Azevedo, Caio Cesar Araujo Morais, Marcelo Brito Passos Amato and Eduardo Leite Vieira Costa
    Citation: Intensive Care Medicine Experimental 2022 10:15
  19. Sepsis is associated with substantial mortality rates. Antibiotic treatment is crucial, but global antibiotic resistance is now classified as one of the top ten global public health risks facing humanity. Ozon...

    Authors: Paul Skorup, Anette Fransson, Jenny Gustavsson, Johan Sjöholm, Henrik Rundgren, Volkan Özenci, Alicia Y. W. Wong, Tomas Karlsson, Christer Svensén and Mattias Günther
    Citation: Intensive Care Medicine Experimental 2022 10:14
  20. Mean circulatory filling pressure (Pmcf) provides information on stressed volume and is crucial for maintaining venous return. This study investigated the Pmcf and other determinants of venous return in dysrhy...

    Authors: Athanasios Chalkias, Eleni Laou, Nikolaos Papagiannakis, Giolanda Varvarousi, Dimitrios Ragias, Anastasios Koutsovasilis, Demosthenes Makris, Dimitrios Varvarousis, Nicoletta Iacovidou, Ioannis Pantazopoulos and Theodoros Xanthos
    Citation: Intensive Care Medicine Experimental 2022 10:13
  21. Fluid resuscitation is the standard treatment to restore circulating blood volume and pressure after massive haemorrhage and shock. Packed red blood cells (PRBC) are transfused to restore haemoglobin levels. R...

    Authors: Wayne B. Dyer, Gabriela Simonova, Sara Chiaretti, Mahe Bouquet, Rebecca Wellburn, Silver Heinsar, Carmen Ainola, Karin Wildi, Kei Sato, Samantha Livingstone, Jacky Y. Suen, David O. Irving, John-Paul Tung, Gianluigi li Bassi and John F. Fraser
    Citation: Intensive Care Medicine Experimental 2022 10:12
  22. Acid–base status is important for understanding pathophysiology, making a diagnosis, planning effective treatment and monitoring progress of critically ill patients. Manual calculations are cumbersome, easily ...

    Authors: Innas Forsal, Mikael Bodelsson, Anders Wieslander, Anders Nilsson, Dominique Pouchoulin and Marcus Broman
    Citation: Intensive Care Medicine Experimental 2022 10:11
  23. The bicaval drainage under veno-venous extracorporeal membrane oxygenation (VV ECMO) was compared in present experimental study to the inferior caval drainage in terms of systemic oxygenation.

    Authors: Jonathan Charbit, Elie Courvalin, Geoffrey Dagod, Pauline Deras, Thomas Laumon, Mehdi Girard, Camille Maury, Hugues Weber and Xavier Capdevila
    Citation: Intensive Care Medicine Experimental 2022 10:10
  24. The pathophysiology of acute respiratory distress syndrome (ARDS) includes the accumulation of protein-rich pulmonary edema in the air spaces and interstitial areas of the lung, variable degrees of epithelial ...

    Authors: Lieuwe D. J. Bos, John G. Laffey, Lorraine B. Ware, Nanon F. L. Heijnen, Pratik Sinha, Brijesh Patel, Matthieu Jabaudon, Julie A. Bastarache, Daniel F. McAuley, Charlotte Summers, Carolyn S. Calfee and Manu Shankar-Hari
    Citation: Intensive Care Medicine Experimental 2022 10:8
  25. Interleukin-1 receptor antagonists can reduce mortality in septic shock patients with hepatobiliary dysfunction and disseminated intravascular coagulation (HBD + DIC), an organ failure pattern with inflammator...

    Authors: Renee R. Anderko, Hernando Gómez, Scott W. Canna, Bita Shakoory, Derek C. Angus, Donald M. Yealy, David T. Huang, John A. Kellum and Joseph A. Carcillo
    Citation: Intensive Care Medicine Experimental 2022 10:6
  26. Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunosuppressive functions sub-classified into monocytic and polymorphonuclear MDSCs (M-MDSCs and PMN-MDSCs). Clinical studies reported...

    Authors: Irene T. Schrijver, Eleni Karakike, Charlotte Théroude, Pétra Baumgartner, Alexandre Harari, Evangelos J. Giamarellos-Bourboulis, Thierry Calandra and Thierry Roger
    Citation: Intensive Care Medicine Experimental 2022 10:5
  27. The use of norepinephrine in the case of life-threatening haemorrhagic shock is well established but widely discussed. The present study was designed to compare the effects of early norepinephrine treatment vs...

    Authors: Rasmus Peter Jakobsen, Elisabeth Charlotte Hansen, Troels Halfeld Nielsen, Carl-Henrik Nordström and Palle Toft
    Citation: Intensive Care Medicine Experimental 2022 10:4
  28. Noise exposure leads to a reduction in cognitive abilities in diverse settings, however, only limited data exist examining the effects of environmental ICU noise on the cognitive performance of ICU professiona...

    Authors: Katja Erne, Samuel E. J. Knobel, Aileen C. Naef, Stephan M. Gerber, Tim Fischer, Fred W. Mast, Joerg C. Schefold, Bjoern Zante, Tobias Nef and Marie-Madlen Jeitziner
    Citation: Intensive Care Medicine Experimental 2022 10:3
  29. Animal models implicate candida colonization facilitating invasive bacterial infections. The clinical relevance of this microbial interaction remains undefined and difficult to study directly. Observations fro...

    Authors: James C. Hurley
    Citation: Intensive Care Medicine Experimental 2022 10:2
  30. Trauma-induced coagulopathy (TIC) is a life-threatening condition associated with high morbidity and mortality. TIC can present with different coagulation defects. In this study, the aim was to determine the e...

    Authors: Pieter H. Sloos, M. Adrie W. Maas, Markus W. Hollmann, Nicole P. Juffermans and Derek J. B. Kleinveld
    Citation: Intensive Care Medicine Experimental 2022 10:1
  31. Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. Wh...

    Authors: C. H. Masterson, A. Ceccato, A. Artigas, C. dos Santos, P. R. Rocco, S. Rolandsson Enes, D. J. Weiss, D. McAuley, M. A. Matthay, K. English, G. F. Curley and J. G. Laffey
    Citation: Intensive Care Medicine Experimental 2021 9:61
  32. In critically ill patients with sepsis, there is a grave lack of effective treatment options to address the illness-defining inappropriate host response. Currently, treatment is limited to source control and s...

    Authors: Michael Bauer, Manu Shankar-Hari, Daniel O. Thomas-Rüddel and Reinhard Wetzker
    Citation: Intensive Care Medicine Experimental 2021 9:63

    The Correspondence to this article has been published in Intensive Care Medicine Experimental 2022 10:29

  33. Heart transplantation (HTx) from brainstem dead (BSD) donors is the gold-standard therapy for severe/end-stage cardiac disease, but is limited by a global donor heart shortage. Consequently, innovative solutio...

    Authors: Louise E. See Hoe, Karin Wildi, Nchafatso G. Obonyo, Nicole Bartnikowski, Charles McDonald, Kei Sato, Silver Heinsar, Sanne Engkilde-Pedersen, Sara Diab, Margaret R. Passmore, Matthew A. Wells, Ai-Ching Boon, Arlanna Esguerra, David G. Platts, Lynnette James, Mahe Bouquet…
    Citation: Intensive Care Medicine Experimental 2021 9:60
  34. Acute heart failure and cardiogenic shock remain highly morbid conditions despite prompt medical therapy in critical care settings. Mechanical circulatory support (MCS) is a promising therapy for these patient...

    Authors: Brian Y. Chang, Zhengyang Zhang, Kimberly Feng, Noam Josephy, Steven P. Keller and Elazer R. Edelman
    Citation: Intensive Care Medicine Experimental 2021 9:62
  35. The effects of selective pulmonary vascular tone alterations on cardiac preload have not been previously examined. Therefore, we evaluated whether changing pulmonary vascular tone either by hypoxia or the inha...

    Authors: Jaap Jan Vos, J. K. Götz Wietasch, Andreas Hoeft and Thomas W. L. Scheeren
    Citation: Intensive Care Medicine Experimental 2021 9:59
  36. Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood co...

    Authors: Klaus Stahl, Uta Carola Hillebrand, Yulia Kiyan, Benjamin Seeliger, Julius J. Schmidt, Heiko Schenk, Thorben Pape, Bernhard M. W. Schmidt, Tobias Welte, Marius M. Hoeper, Agnes Sauer, Malgorzata Wygrecka, Christian Bode, Heiner Wedemeyer, Hermann Haller and Sascha David
    Citation: Intensive Care Medicine Experimental 2021 9:57
  37. Acute Kidney Injury (AKI) is a common clinical complication. Plasma/serum neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as a rapid marker of AKI. However, NGAL is not kidney-specific. It ...

    Authors: Arie Passov, Minna Ilmakunnas, Marjut Pihlajoki, Kethe Hermunen, Marko Lempinen, Ilkka Helanterä, Villemikko Kailari, Markku Heikinheimo, Sture Andersson and Eero Pesonen
    Citation: Intensive Care Medicine Experimental 2021 9:56
  38. High rates of inflation energy delivery coupled with transpulmonary tidal pressures of sufficient magnitude may augment the risk of damage to vulnerable, stress-focused units within a mechanically heterogeneou...

    Authors: John J. Marini, Philip S. Crooke, Pierre Tawfik, Robert L. Chatburn, David J. Dries and Luciano Gattinoni
    Citation: Intensive Care Medicine Experimental 2021 9:55
  39. The COVID-19 pandemic has caused a global mechanical ventilator shortage for treatment of severe acute respiratory failure. Development of novel breathing devices has been proposed as a low cost, rapid solutio...

    Authors: Aleksandra B. Gruslova, Nitesh Katta, Andrew G. Cabe, Scott F. Jenney, Jonathan W. Valvano, Tim B. Phillips, Austin B. McElroy, Robert K. LaSalle, Aydin Zahedivash, Van N. Truskett, Nishi Viswanathan, Marc D. Feldman, Richard B. Wettstein, Thomas E. Milner and Stephen Derdak
    Citation: Intensive Care Medicine Experimental 2021 9:54
  40. Plasma hyaluronan concentrations are increased during sepsis but underlying mechanisms leading to high plasma hyaluronan concentration are poorly understood. In this study we evaluate the roles of plasma hyalu...

    Authors: Jaap van der Heijden, Constantinos Kolliopoulos, Paul Skorup, Marko Sallisalmi, Paraskevi Heldin, Michael Hultström and Jyrki Tenhunen
    Citation: Intensive Care Medicine Experimental 2021 9:53