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Intensive Care Medicine Experimental
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  1. People with type 2 diabetes mellitus treated with sodium-glucose transporter-2 inhibitors (SGLT2i) have lower rates of acute kidney injury (AKI). Sepsis is responsible for the majority of AKI in critically ill...

    Authors: Abraham H. Hulst, Connie P. C. Ow, Clive N. May, Sally H. Hood, Mark P. Plummer, Jeroen Hermanides, Daniël H. van Raalte, Adam M. Deane, Rinaldo Bellomo and Yugeesh R. Lankadeva
    Citation: Intensive Care Medicine Experimental 2024 12:64
    Content type: Research Articles Published on:

  2. Tracheostomized patients often present with muscle weakness, altered consciousness, or swallowing difficulties. Hence, the literature is scarce regarding the challenging management of tracheostomy weaning. The...

    Authors: Yann Combret, Margaux Machefert, Guillaume Prieur, Emeline Fresnel, Elise Artaud-Macari, Bouchra Lamia, Marius Lebret and Clément Medrinal
    Citation: Intensive Care Medicine Experimental 2024 12:63
    Content type: Research Articles Published on:

  3. For decades, left ventricular ejection fraction (LVEF < 35%) has been a mainstay for identifying heart failure (HF) patients most likely to benefit from an implantable cardioverter defibrillator (ICD). However...

    Authors: Nathan Engstrom, Hayley L. Letson, Kevin Ng and Geoffrey P. Dobson
    Citation: Intensive Care Medicine Experimental 2024 12:62
    Content type: Hypothesis Published on:

  4. Currently, there is no marker of efficacy of red blood cell (RBC) transfusion. This study describes the impact of RBC transfusion on mitochondrial oxygen tension (mitoPO2) and mitochondrial oxygen consumption (mi...

    Authors: M. Baysan, B. Hilderink, L. van Manen, C. Caram-Deelder, E. G. Mik, N. P. Juffermans, J. G. van der Bom and M. S. Arbous
    Citation: Intensive Care Medicine Experimental 2024 12:61
    Content type: Research Articles Published on:

  5. The spatiotemporal progression and patterns of tissue deformation in ventilator-induced lung injury (VILI) remain understudied. Our aim was to identify lung clusters based on their regional mechanical behavior...

    Authors: Pablo Cruces, Jaime Retamal, Andrés Damián, Graciela Lago, Fernanda Blasina, Vanessa Oviedo, Tania Medina, Agustín Pérez, Lucía Vaamonde, Rosina Dapueto, Sebastian González-Dambrauskas, Alberto Serra, Nicolas Monteverde-Fernandez, Mauro Namías, Javier Martínez and Daniel E. Hurtado
    Citation: Intensive Care Medicine Experimental 2024 12:60
    Content type: Research Articles Published on:

  7. Treatment and prevention of intracranial hypertension (IH) to minimize secondary brain injury are central to the neurocritical care management of traumatic brain injury (TBI). Predicting the onset of IH in adv...

    Authors: Jun Zhu, Yingchi Shan, Yihua Li, Xuxu Xu, Xiang Wu, Yajun Xue and Guoyi Gao
    Citation: Intensive Care Medicine Experimental 2024 12:58
    Content type: Research Articles Published on:

  8. A sepsis-like syndrome is known to occur after cardiac arrest, leading to cerebral infiltration by white blood cells (WBC). We hypothesized that pharmacological sequestration of WBC, and more specifically lymp...

    Authors: Yara Abi Zeid Daou, Fanny Lidouren, Antoine Bois, Naoto Watanabe, Ali Jendoubi, Estelle Faucher, Mathieu Surenaud, Sophie Chateau-Joubert, Sophie Hue, Bijan Ghaleh, Matthias Kohlhauer and Renaud Tissier
    Citation: Intensive Care Medicine Experimental 2024 12:57
    Content type: Research Articles Published on:

  9. The aim of this experimental study was to elucidate whether different distances between central venous catheter tips can affect drug clearance during continuous renal replacement therapy (CRRT). Central venous...

    Authors: Anna Bandert, Miklós Lipcsey, Robert Frithiof, Anders Larsson and David Smekal
    Citation: Intensive Care Medicine Experimental 2024 12:56
    Content type: Research Articles Published on:

  10. Risk stratification and outcome prediction are crucial for intensive care resource planning. In addressing the large data sets of intensive care unit (ICU) patients, we employed the Explainable Boosting Machin...

    Authors: Andreas Körner, Benjamin Sailer, Sibel Sari-Yavuz, Helene A. Haeberle, Valbona Mirakaj, Alice Bernard, Peter Rosenberger and Michael Koeppen
    Citation: Intensive Care Medicine Experimental 2024 12:55
    Content type: Research Articles Published on:

  11. Continuous monitoring of mitral annular plane systolic excursion (MAPSE) using transesophageal echocardiography (TEE) may improve the evaluation of left ventricular (LV) function in postoperative intensive car...

    Authors: Jinyang Yu, Anders Austlid Taskén, Erik Andreas Rye Berg, Tomas Dybos Tannvik, Katrine Hordnes Slagsvold, Idar Kirkeby-Garstad, Bjørnar Grenne, Gabriel Kiss and Svend Aakhus
    Citation: Intensive Care Medicine Experimental 2024 12:54
    Content type: Research Articles Published on:

  12. Dipeptidyl peptidase 3 (DPP3) is a ubiquitous cytosolic enzyme released into the bloodstream after tissue injury, that can degrade angiotensin II. High concentrations of circulating DPP3 (cDPP3) have been asso...

    Authors: Bruno Garcia, Benoit ter Schiphorst, Karine Santos, Fuhong Su, Laurence Dewachter, Francisco Vasques-Nóvoa, Estela Rocha-Oliveira, Roberto Roncon-Albuquerque Jr., Theo Uba, Oliver Hartmann, Adrien Picod, Feriel Azibani, Jacques Callebert, Serge Goldman, Filippo Annoni, Raphaël Favory…
    Citation: Intensive Care Medicine Experimental 2024 12:53
    Content type: Research Articles Published on:

  14. Recirculation is a common problem in venovenous extracorporeal membrane oxygenation (VV ECMO) and may limit the effect of ECMO treatment due to less efficient blood oxygenation or unfavorable ECMO and ventilat...

    Authors: Lars Prag Antonsen, Andreas Espinoza, Per Steinar Halvorsen, Itai Schalit, Harald Bergan, Didrik Lilja and Svein Aslak Landsverk
    Citation: Intensive Care Medicine Experimental 2024 12:51
    Content type: Research Articles Published on:

  15. Pancreatic stone protein (PSP) exhibits potential as a plasma biomarker for infection diagnosis and risk stratification in critically ill patients, but its significance in nosocomial infection and intensive ca...

    Authors: Diede Verlaan, Lennie P. G. Derde, Tom van der Poll, Marc J. M. Bonten and Olaf L. Cremer
    Citation: Intensive Care Medicine Experimental 2024 12:50
    Content type: Research Articles Published on:

  16. We tested the ability of a physiologically driven minimally invasive closed-loop algorithm, called Resuscitation based on Functional Hemodynamic Monitoring (ReFit), to stabilize for up to 3 h a porcine model o...

    Authors: Michael R. Pinsky, Hernando Gomez, Francis X. Guyette, Leonard Weiss, Artur Dubrawski, Jim Leonard, Robert MacLachlan, Lisa Gordon, Theodore Lagattuta, David Salcido and Ronald Poropatich
    Citation: Intensive Care Medicine Experimental 2024 12:44
    Content type: Research Articles Published on:

  18. Catecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock. However, excessive or sustained adrenergic activation drives detrimental ca...

    Authors: Christine Bode, Sebastian Preissl, Lutz Hein and Achim Lother
    Citation: Intensive Care Medicine Experimental 2024 12:48
    Content type: Research Articles Published on:

  19. Therapeutic drug monitoring (TDM) of anti-infectives such as linezolid is routinely performed in blood of intensive care unit (ICU) patients to optimize target attainment. However, the concentration at the sit...

    Authors: Diana Rebholz, Uwe Liebchen, Michael Paal, Michael Vogeser, Johannes Starp, Caroline Gräfe, Clara I. Brozat, Felix L. Happich, Katharina Habler and Christina Scharf
    Citation: Intensive Care Medicine Experimental 2024 12:47
    Content type: Research Articles Published on:

  20. Assessment of dynamic parameters to guide fluid administration is one of the mainstays of current resuscitation strategies. Each test has its own limitations, but passive leg raising (PLR) has emerged as one o...

    Authors: Mario Bruna, Sebastian Alfaro, Felipe Muñoz, Liliana Cisternas, Cecilia Gonzalez, Rodrigo Conlledo, Rodrigo Ulloa-Morrison, Marcos Huilcaman, Jaime Retamal, Ricardo Castro, Philippe Rola, Adrian Wong, Eduardo R. Argaiz, Roberto Contreras, Glenn Hernandez and Eduardo Kattan
    Citation: Intensive Care Medicine Experimental 2024 12:46
    Content type: Research Articles Published on:

  23. Lung volume optimization maneuvers (LVOM) are necessary to make physiologic use of high-frequency oscillatory ventilation (HFOV), but lung behavior during such maneuvers has not been studied to determine lung ...

    Authors: Pauline de Jager, Alette A. Koopman, Dick G. Markhorst and Martin C. J. Kneyber
    Citation: Intensive Care Medicine Experimental 2024 12:42
    Content type: Research Articles Published on:

  24. The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired ...

    Authors: Rolf Erlebach, Alix Buhlmann, Rea Andermatt, Benjamin Seeliger, Klaus Stahl, Christian Bode, Reto Schuepbach, Pedro David Wendel-Garcia and Sascha David
    Citation: Intensive Care Medicine Experimental 2024 12:41
    Content type: Research Articles Published on:

  25. To assess the incidences of Herpes Simplex-1 and 2 (HSV-1, HSV-2), Cytomegalovirus (CMV), Epstein–Barr Virus (EBV) reactivations in critically ill COVID-19 patients. To determine the association between viral ...

    Authors: Alessia Mattei, Lorenzo Schiavoni, Elisabetta Riva, Massimo Ciccozzi, Roberta Veralli, Angela Urselli, Vincenzo Citriniti, Antonio Nenna, Giuseppe Pascarella, Fabio Costa, Rita Cataldo, Felice Eugenio Agrò and Massimiliano Carassiti
    Citation: Intensive Care Medicine Experimental 2024 12:40
    Content type: Research Articles Published on:

  26. In selected cases of cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is combined with trans valvular micro axial flow pumps (ECMELLA). Observational studies indicate that ECMELL...

    Authors: Emilie Gregers, Peter H. Frederiksen, Nanna L. J. Udesen, Louise Linde, Ann Banke, Amalie L. Povlsen, Jeppe P. Larsen, Christian Hassager, Lisette O. Jensen, Jens F. Lassen, Henrik Schmidt, Hanne B. Ravn, Peter M. H. Heegaard and Jacob E. Møller
    Citation: Intensive Care Medicine Experimental 2024 12:39
    Content type: Research Articles Published on:

  27. The use of hemoadsorption (HA) has become popular in the treatment of vasoplegic states associated with massive cytokine release, including septic shock. However, this approach does not seem to be based on rob...

    Authors: Vaclav Tegl, Jan Horak, Lukas Nalos, Michala Horakova, Milan Stengl, Martin Matejovic and Jan Benes
    Citation: Intensive Care Medicine Experimental 2024 12:38
    Content type: Research Articles Published on:

  28. Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in cl...

    Authors: Bashar N. Hilderink, Reinier F. Crane, Bas van den Bogaard, Janesh Pillay and Nicole P. Juffermans
    Citation: Intensive Care Medicine Experimental 2024 12:37
    Content type: Research Articles Published on:

  29. In refractory out-of-hospital cardiac arrest, the patient is commonly transported to hospital with mechanical continuous chest compressions (CCC). Limited data are available on the optimal ventilation strategy...

    Authors: Jukka Kopra, Erik Litonius, Pirkka T. Pekkarinen, Merja Laitinen, Juho A. Heinonen, Luca Fontanelli and Markus B. Skrifvars
    Citation: Intensive Care Medicine Experimental 2024 12:36
    Content type: Research Articles Published on:

  31. The same principle behind pulse wave analysis can be applied on the pulmonary artery (PA) pressure waveform to estimate right ventricle stroke volume (RVSV). However, the PA pressure waveform might be influenc...

    Authors: Arnoldo Santos, M. Ignacio Monge-García, João Batista Borges, Jaime Retamal, Gerardo Tusman, Anders Larsson and Fernando Suarez-Sipmann
    Citation: Intensive Care Medicine Experimental 2024 12:34
    Content type: Research Articles Published on:

  32. Liver function of intensive care patients is routinely monitored by static blood pathology. For specific indications, liver specific cytochrome activity may be measured by the commercially available maximum li...

    Authors: Thomas Köhler, Elke Schwier, Janina Praxenthaler, Carmen Kirchner, Günther Winde, Björn Koos and Dietrich Henzler
    Citation: Intensive Care Medicine Experimental 2024 12:33
    Content type: Research Articles Published on:

  33. Reinforcement learning (RL) holds great promise for intensive care medicine given the abundant availability of data and frequent sequential decision-making. But despite the emergence of promising algorithms, R...

    Authors: Luca F. Roggeveen, Ali el Hassouni, Harm-Jan de Grooth, Armand R. J. Girbes, Mark Hoogendoorn and Paul W. G. Elbers
    Citation: Intensive Care Medicine Experimental 2024 12:32
    Content type: Research Articles Published on:

  34. The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney f...

    Authors: Simone Gattarello, Fabio Lombardo, Federica Romitti, Rosanna D’Albo, Mara Velati, Isabella Fratti, Tommaso Pozzi, Rosmery Nicolardi, Antonio Fioccola, Mattia Busana, Francesca Collino, Peter Herrmann, Luigi Camporota, Michael Quintel, Onnen Moerer, Leif Saager…
    Citation: Intensive Care Medicine Experimental 2024 12:31
    Content type: Research Articles Published on:

  35. Mechanical power (MP) is the energy delivered by the ventilator to the respiratory system and combines factors related to the development of ventilator-induced lung injury (VILI). Flow-controlled ventilation (...

    Authors: Julien P. Van Oosten, Juliette E. Francovich, Peter Somhorst, Philip van der Zee, Henrik Endeman, Diederik A. M. P. J. Gommers and Annemijn H. Jonkman
    Citation: Intensive Care Medicine Experimental 2024 12:30
    Content type: Research Articles Published on:

  37. Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predi...

    Authors: Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J. Dwivedi, Ji Zhou, Manoj M. Lalu, Asher A. Mendelson, Braedon McDonald, Colin A. Kretz, Alison E. Fox-Robichaud and Patricia C. Liaw
    Citation: Intensive Care Medicine Experimental 2024 12:28
    Content type: Research Articles Published on:

  38. Aim of this study was to evaluate feasibility and effects of individualised flow-controlled ventilation (FCV), based on compliance guided pressure settings, compared to standard of pressure-controlled ventilat...

    Authors: Julia Abram, Patrick Spraider, Julian Wagner, Gabriel Putzer, Manuela Ranalter, Sarah Rinner, Andrea Katharina Lindner, Bernhard Glodny, Tobias Hell, Tom Barnes, Dietmar Enk and Judith Martini
    Citation: Intensive Care Medicine Experimental 2024 12:27
    Content type: Research Articles Published on:

  39. Coronary artery calcification (CAC) is associated with poor outcome in critically ill patients. A deterioration in cardiac conduction and loss of myocardial tissue could be an underlying cause. Vectorcardiogra...

    Authors: Eda Aydeniz, Frank van Rosmalen, Jip de Kok, Bibi Martens, Alma M. A. Mingels, Mustafa Emin Canakci, Casper Mihl, Kevin Vernooy, Frits W. Prinzen, Joachim E. Wildberger, Iwan C. C. van der Horst, Bas C. T. van Bussel and Rob G. H. Driessen
    Citation: Intensive Care Medicine Experimental 2024 12:26
    Content type: Research Articles Published on:

  40. Expiratory time constant (τ) objectively assesses the speed of exhalation and can guide adjustments of the respiratory rate and the I:E ratio with the goal of achieving complete exhalation. Multiple methods of ob...

    Authors: Filip Depta, Caitlyn M. Chiofolo, Nicolas W. Chbat, Neil R. Euliano, Michael A. Gentile, Dušan Rybár, Viliam Donič and Marko Zdravkovic
    Citation: Intensive Care Medicine Experimental 2024 12:25
    Content type: Research Articles Published on:

  41. Glucocorticoids are commonly used in patients with or at-risk for acute respiratory distress syndrome (ARDS), but optimal use remains unclear despite well-conducted clinical trials. We performed a secondary an...

    Authors: Nameer Al-Yousif, Seyed M. Nouraie, Matthew J. Broerman, Yingze Zhang, Tomeka L. Suber, John Evankovich, William G. Bain, Georgios D. Kitsios, Bryan J. McVerry and Faraaz A. Shah
    Citation: Intensive Care Medicine Experimental 2024 12:24
    Content type: Research Articles Published on:

  43. Disorders of the gut microbiome could be responsible for the progression of multiple organ dysfunction syndrome. In this study, we examined the effect of esmolol on the gut microbiome in a rat model of sepsis ...

    Authors: Bo Yao, Fu-hua Wang, Xiao-ning Han, Jun Yang, Ping Xue, Qi Qi, Guang-yao Wei and Jin-yan Xing
    Citation: Intensive Care Medicine Experimental 2024 12:22
    Content type: Research Articles Published on:

  44. Obtaining a properly fitting non-invasive ventilation (NIV) mask to treat acute respiratory failure is a major challenge, especially in young children and patients with craniofacial abnormalities. Personalizat...

    Authors: Rosemijne R. W. P. Pigmans, Rozalinde Klein-Blommert, Monica C. van Gestel, Dick G. Markhorst, Peter Hammond, Pim Boomsma, Tim Daams, Julia M. A. de Jong, Paul M. Heeman, Job B. M. van Woensel, Coen D. Dijkman and Reinout A. Bem
    Citation: Intensive Care Medicine Experimental 2024 12:21
    Content type: Research Articles Published on:

  45. Lung- and diaphragm-protective (LDP) ventilation may prevent diaphragm atrophy and patient self-inflicted lung injury in acute respiratory failure, but feasibility is uncertain. The objectives of this study we...

    Authors: Damian Ratano, Binghao Zhang, Jose Dianti, Dimitrios Georgopoulos, Laurent J. Brochard, Timothy C. Y. Chan and Ewan C. Goligher
    Citation: Intensive Care Medicine Experimental 2024 12:20
    Content type: Research Articles Published on:

  46. Acute respiratory distress syndrome (ARDS) is a form of respiratory failure stemming from various underlying conditions that ultimately lead to inflammation and lung fibrosis. Bromodomain and Extra-Terminal mo...

    Authors: Manuela Iten, Camille Gschwend, Alessandro Ostini, David Robert Cameron, Christine Goepfert, David Berger and Matthias Haenggi
    Citation: Intensive Care Medicine Experimental 2024 12:19
    Content type: Research Articles Published on:

  47. Several studies have demonstrated associations between greater rate/volume of intravenous (IV) fluid administration and poorer clinical outcomes. One postulated mechanism for harm from exogenous fluids is shed...

    Authors: Sara Sukudom, Lisa Smart and Stephen Macdonald
    Citation: Intensive Care Medicine Experimental 2024 12:16
    Content type: Reviews Published on:

  48. Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the “obesity paradox...

    Authors: Mikaela Eng, Keshikaa Suthaaharan, Logan Newton, Fatima Sheikh and Alison Fox-Robichaud
    Citation: Intensive Care Medicine Experimental 2024 12:15
    Content type: Reviews Published on:

    The Correction to this article has been published in Intensive Care Medicine Experimental 2024 12:52

  50. Authors: Raghavan Murugan, Kianoush Kashani and Paul M. Palevsky
    Citation: Intensive Care Medicine Experimental 2024 12:17
    Content type: Letter to the Editor Published on:

    The original article was published in Intensive Care Medicine Experimental 2024 12:18

    The Correspondence to this article has been published in Intensive Care Medicine Experimental 2024 12:18

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  • ISSN: 2197-425X (electronic)