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  1. Research

    Fully automated life support: an implementation and feasibility pilot study in healthy pigs

    Automated systems are available in various application areas all over the world for the purpose of reducing workload and increasing safety. However, such support systems that would aid caregivers are still lac...

    Wilfried Klingert, Jörg Peter, Christian Thiel, Karolin Thiel, Wolfgang Rosenstiel, Kathrin Klingert, Christian Grasshoff, Alfred Königsrainer and Martin Schenk

    Intensive Care Medicine Experimental 2018 6:2

    Published on: 16 January 2018

  2. Letter to the Editor

    HLA-DR expression in neonates after cardiac surgery under cardiopulmonary bypass: a pilot study

    Monocyte HLA-DR expression has been reported as a marker of immunosuppression and a predictor of sepsis development. However, to date, there is no report on monocyte HLA-DR monitoring exclusively in neonates (...

    Alexis Chenouard, Cécile Braudeau, Nicolas Cottron, Pierre Bourgoin, Nina Salabert, Antoine Roquilly, Régis Josien, Nicolas Joram and Karim Asehnoune

    Intensive Care Medicine Experimental 2018 6:1

    Published on: 11 January 2018

  3. Research

    Volume-replacement ratio for crystalloids and colloids during bleeding and resuscitation: an animal experiment

    Fluid resuscitation remains a cornerstone in the management of acute bleeding. According to Starling's “Three-compartment model”, four-times more crystalloids have the same volume effect as colloids. However, ...

    Ildikó László, Gábor Demeter, Nándor Öveges, Dániel Érces, József Kaszaki, Krisztián Tánczos and Zsolt Molnár

    Intensive Care Medicine Experimental 2017 5:52

    Published on: 20 December 2017

  4. Research

    Combinatorial therapy with two pro-coagulants and one osmotic agent reduces the extent of the lesion in the acute phase of spinal cord injury in the rat

    Spinal cord injury (SCI) is a complex disease that leads to a motor, sensitive, and vegetative impairment. So far, single therapies are ineffective for treating SCI in humans and a multifactorial therapeutic a...

    Mathieu Boutonnet, Elisabeth Laemmel, Eric Vicaut, Jacques Duranteau and Marc Soubeyrand

    Intensive Care Medicine Experimental 2017 5:51

    Published on: 11 December 2017

  5. Research

    Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support

    Although anthrax immune globulin (AIG) improved survival in antibiotic-treated Bacillus anthracis-challenged animal models, whether it adds to the benefit of conventional hemodynamic support for B. anthracis toxi...

    Dante A. Suffredini, Xizhong Cui, Dharmvir Jaswal, Kenneth E. Remy, Yan Li, Junfeng Sun, Steven B. Solomon, Yvonne Fitz, Mahtab Moayeri, Stephen Leppla and Peter Q. Eichacker

    Intensive Care Medicine Experimental 2017 5:48

    Published on: 23 October 2017

  6. Research

    An experimental model to measure the ability of headphones with active noise control to reduce patient’s exposure to noise in an intensive care unit

    Defining the association between excessive noise in intensive care units, sleep disturbance and morbidity, including delirium, is confounded by the difficulty of implementing successful strategies to reduce pa...

    Stuart Gallacher, Doyo Enki, Sian Stevens and Mark J. Bennett

    Intensive Care Medicine Experimental 2017 5:47

    Published on: 17 October 2017

  7. Research

    Effects of regional perfusion block in healthy and injured lungs

    Severe hypoperfusion can cause lung damage. We studied the effects of regional perfusion block in normal lungs and in the lungs that had been conditioned by lavage with 500 ml saline and high V ...

    Barbara Cambiaghi, Francesco Vasques, Onnen Mörer, Christian Ritter, Tommaso Mauri, Nils Kunze-Szikszay, Karin Holke, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Elias Schulze-Kalthoff, Tommaso Tonetti, Günter Hahn, Michael Quintel and Luciano Gattinoni

    Intensive Care Medicine Experimental 2017 5:46

    Published on: 13 October 2017

  8. Research

    Cardiopulmonary bypass in the newborn: effects of circulatory cell-free hemoglobin and hyperoxia evaluated in a novel rat pup model

    Infants with congenital heart defects (CHD) are at risk for white matter brain injury. This novel rat pup model characterizes the systemic effects of intravasal cell-free hemoglobin and hyperoxia, hypothesizin...

    Åsa Jungner, Suvi Vallius, Matteo Bruschettini, Olga Romantsik, Magnus Gram and David Ley

    Intensive Care Medicine Experimental 2017 5:45

    Published on: 4 October 2017

  9. Research

    Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS

    Systemic inflammatory response syndrome (SIRS) is a clinical syndrome following inflammation. Clinically, it is difficult to distinguish SIRS following an infection, i.e., sepsis, from non-infectious SIRS. Mye...

    Irene T. Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu and Dylan W. de Lange

    Intensive Care Medicine Experimental 2017 5:43

    Published on: 15 September 2017

  10. Research

    Fluid loading and norepinephrine infusion mask the left ventricular preload decrease induced by pleural effusion

    Pleural effusion (PLE) may lead to low blood pressure and reduced cardiac output. Low blood pressure and reduced cardiac output are often treated with fluid loading and vasopressors. This study aimed to determ...

    Kristian Borup Wemmelund, Viktor Kromann Ringgård, Simon Tilma Vistisen, Janus Adler Hyldebrandt, Erik Sloth and Peter Juhl-Olsen

    Intensive Care Medicine Experimental 2017 5:42

    Published on: 11 September 2017

  11. Research

    Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model

    Mechanical ventilation with positive end expiratory pressure and low tidal volume, i.e. protective ventilation, is recommended in patients with acute respiratory distress syndrome. However, the effect of prote...

    Jesper Sperber, Axel Nyberg, Miklos Lipcsey, Åsa Melhus, Anders Larsson, Jan Sjölin and Markus Castegren

    Intensive Care Medicine Experimental 2017 5:40

    Published on: 31 August 2017

  12. Research

    Whole blood microRNA markers are associated with acute respiratory distress syndrome

    MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagno...

    Zhaozhong Zhu, Liming Liang, Ruyang Zhang, Yongyue Wei, Li Su, Paula Tejera, Yichen Guo, Zhaoxi Wang, Quan Lu, Andrea A. Baccarelli, Xi Zhu, Ednan K. Bajwa, B. Taylor Thompson, Guo-Ping Shi and David C. Christiani

    Intensive Care Medicine Experimental 2017 5:38

    Published on: 30 August 2017

  13. Research

    Automated bedside flow cytometer for mHLA-DR expression measurement: a comparison study with reference protocol

    In various ICU conditions, measurement of diminished expression of human leukocyte antigen-DR on circulating monocytes (mHLA-DR) by flow cytometry appears to be a reliable marker of acquired immunosuppression....

    Mehdi Zouiouich, Morgane Gossez, Fabienne Venet, Thomas Rimmelé and Guillaume Monneret

    Intensive Care Medicine Experimental 2017 5:39

    Published on: 30 August 2017

  14. Research

    Optimal esophageal balloon volume for accurate estimation of pleural pressure at end-expiration and end-inspiration: an in vitro bench experiment

    Esophageal pressure, used as a surrogate for pleural pressure, is commonly measured by air-filled balloon, and the accuracy of measurement depends on the proper balloon volume. It has been found that larger fi...

    Yan-Lin Yang, Xuan He, Xiu-Mei Sun, Han Chen, Zhong-Hua Shi, Ming Xu, Guang-Qiang Chen and Jian-Xin Zhou

    Intensive Care Medicine Experimental 2017 5:35

    Published on: 2 August 2017

  15. Research

    Impact of membrane lung surface area and blood flow on extracorporeal CO2 removal during severe respiratory acidosis

    Veno-venous extracorporeal CO2 removal (vv-ECCO2R) is increasingly being used in the setting of acute respiratory failure. Blood flow rates through the device range from 200 ml/min to more than 1500 ml/min, and t...

    Christian Karagiannidis, Stephan Strassmann, Daniel Brodie, Philine Ritter, Anders Larsson, Ralf Borchardt and Wolfram Windisch

    Intensive Care Medicine Experimental 2017 5:34

    Published on: 1 August 2017

  16. Research

    Heart rate variability in critical care medicine: a systematic review

    Heart rate variability (HRV) has been used to assess cardiac autonomic activity in critically ill patients, driven by translational and biomarker research agendas. Several clinical and technical factors can in...

    Shamir N. Karmali, Alberto Sciusco, Shaun M. May and Gareth L. Ackland

    Intensive Care Medicine Experimental 2017 5:33

    Published on: 12 July 2017

  17. Research

    Sepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study

    Platelets have been involved in both immune surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to...

    Nathalie Layios, Céline Delierneux, Alexandre Hego, Justine Huart, Christian Gosset, Christelle Lecut, Nathalie Maes, Pierre Geurts, Arnaud Joly, Patrizio Lancellotti, Adelin Albert, Pierre Damas, André Gothot and Cécile Oury

    Intensive Care Medicine Experimental 2017 5:32

    Published on: 12 July 2017

  18. Research

    Evaluation of an ADVanced Organ Support (ADVOS) system in a two-hit porcine model of liver failure plus endotoxemia

    Novel extracorporeal procedures are constantly being developed and evaluated for use in patients with sepsis. Preclinical evaluation of such procedures usually requires testing in large animal models. In the p...

    Ahmed Al-Chalabi, Edouard Matevossian, Anne von Thaden, Catherine Schreiber, Peter Radermacher, Wolfgang Huber, Aritz Perez Ruiz de Garibay and Bernhard Kreymann

    Intensive Care Medicine Experimental 2017 5:31

    Published on: 4 July 2017

  19. Research

    Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock

    Cystathionine-γ-lyase (CSE) was shown to have a regulatory role in glucose metabolism. Circulatory shock can induce metabolic stress, thereby leading to hyperglycemia and mitochondrial dysfunction. In vitro da...

    Tamara Merz, Josef A. Vogt, Ulrich Wachter, Enrico Calzia, Csaba Szabo, Rui Wang, Peter Radermacher and Oscar McCook

    Intensive Care Medicine Experimental 2017 5:30

    Published on: 14 June 2017

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