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Volume 7 Supplement 1

Proceedings from the Third International Symposium on Acute Pulmonary Injury and Translational Research (INSPIRES III)

Research

Publication of this supplement has not been supported by sponsorship. Information about the source of funding for publication charges can be found in the individual articles. The articles have undergone the journal's standard peer review process for supplements. The Supplement Editors declare that they have no competing interests.

Amsterdam, the Netherlands4-5 December 2018

Edited by Nicole P. Juffermans and José A. Lorente

  1. Current treatment of acute respiratory distress syndrome (ARDS) in critically ill patients is limited to supportive measures including mechanical ventilation. It is our view that effective therapies for ARDS c...

    Authors: Nicole P. Juffermans, Marcus Schultz, Lieuwe D. Bos, Oscar Penuelas, John Laffey and Jose A. Lorente

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):40

    Content type: Meeting report

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  2. Mechanical ventilation is a life-supportive therapy, but can also promote damage to pulmonary structures, such as epithelial and endothelial cells and the extracellular matrix, in a process referred to as vent...

    Authors: Pedro Leme Silva, Lorenzo Ball, Patricia R. M. Rocco and Paolo Pelosi

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):38

    Content type: Review

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  3. Mechanical ventilation is common in critically ill patients. This life-saving treatment can cause complications and is also associated with long-term sequelae. Patient-ventilator asynchronies are frequent but ...

    Authors: Candelaria de Haro, Ana Ochagavia, Josefina López-Aguilar, Sol Fernandez-Gonzalo, Guillem Navarra-Ventura, Rudys Magrans, Jaume Montanyà and Lluís Blanch

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):43

    Content type: Review

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  4. Mechanical ventilation [MV] is a life-saving technique delivered to critically ill patients incapable of adequately ventilating and/or oxygenating due to respiratory or other disease processes. This necessaril...

    Authors: Oscar Peñuelas, Elena Keough, Lucía López-Rodríguez, Demetrio Carriedo, Gesly Gonçalves, Esther Barreiro and José Ángel Lorente

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):48

    Content type: Review

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  5. The biological effects and physiological consequences of hypercapnia are increasingly understood. The literature on hypercapnia is confusing, and at times contradictory. On the one hand, it may have protective...

    Authors: Luis Morales-Quinteros, Marta Camprubí-Rimblas, Josep Bringué, Lieuwe D. Bos, Marcus J. Schultz and Antonio Artigas

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):39

    Content type: Review

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  6. Semi-quantification of lung aeration by ultrasound helps to assess presence and extent of pulmonary pathologies, including the acute respiratory distress syndrome (ARDS). It is uncertain which lung regions add...

    Authors: Luigi Pisani, Veronica Vercesi, Patricia S. I. van Tongeren, Wim K. Lagrand, Stije J. Leopold, Mischa A. M. Huson, Patricia C. Henwood, Andrew Walden, Marry R. Smit, Elisabeth D. Riviello, Paolo Pelosi, Arjen M. Dondorp and Marcus J. Schultz

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):44

    Content type: Research

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  7. Extracorporeal life support (ECLS) encompasses a wide range of extracorporeal modalities that offer short- and intermediate-term mechanical support to the failing heart or lung. Apart from the daily use of car...

    Authors: Abdulrahman Al-Fares, Tommaso Pettenuzzo and Lorenzo Del Sorbo

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):46

    Content type: Review

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  8. In acute respiratory distress syndrome (ARDS), uncontrolled production of activators of coagulation and proinflammatory mediators results in a shift from an adequate local innate immune response to hypercoagul...

    Authors: Jenny Juschten, Sarah Anne Ingelse, Martinus Adrianus Wilhelmus Maas, Armand Roelof Johan Girbes, Nicole Petra Juffermans, Marcus Josephus Schultz and Pieter Roel Tuinman

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):36

    Content type: Research

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  9. Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standa...

    Authors: Derek J. B. Kleinveld, Mathijs R. Wirtz, Daan P. van den Brink, M. Adrie W. Maas, Joris J. T. H. Roelofs, J. Carel Goslings, Markus W. Hollmann and Nicole P. Juffermans

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):42

    Content type: Research

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  10. The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS). The current study explored the association between pulmonary depositions...

    Authors: Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz and Wim K. Lagrand

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):35

    Content type: Research

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  11. Mesenchymal stem/stromal cells (MSCs) are undergoing intensive translational research for several debilitating conditions, including critical illnesses such as ARDS and sepsis. MSCs exert diverse biologic effe...

    Authors: Claire H. Masterson, Gerard F. Curley and John G. Laffey

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):41

    Content type: Review

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  12. To describe the possible modes of action of probiotics and provide a systematic review of the current evidence on the efficacy of probiotics to prevent ventilator-associated pneumonia (VAP) in critically ill p...

    Authors: Marel C. E. van Ruissen, Lieuwe D. Bos, Robert P. Dickson, Arjen M. Dondorp, Constance Schultsz and Marcus J. Schultz

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):37

    Content type: Review

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  13. Anemia of inflammation (AI) is common in critically ill patients. Although this syndrome negatively impacts the outcome of critical illness, understanding of its pathophysiology is limited. Also, new therapies...

    Authors: Margit Boshuizen, Robin van Bruggen, Sebastian A. Zaat, Marcus J. Schultz, Eli Aguilera, Ana Motos, Tarek Senussi, Francesco Antonio Idone, Paolo Pelosi, Antonio Torres, Gianluigi Li Bassi and Nicole P. Juffermans

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):47

    Content type: Research

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  14. Sepsis is a highly lethal disorder. Organ dysfunction in sepsis is not defined as a clinicopathological entity but rather by changes in clinical, physiological, or biochemical parameters. Pathogenesis and spec...

    Authors: Antonio M. Garofalo, Marta Lorente-Ros, Gesly Goncalvez, Demetrio Carriedo, Aída Ballén-Barragán, Ana Villar-Fernández, Óscar Peñuelas, Raquel Herrero, Rosario Granados-Carreño and José A. Lorente

    Citation: Intensive Care Medicine Experimental 2019 7(Suppl 1):45

    Content type: Review

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