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Table 1 Overview on monoclonal anti-ADM antibodies and their characteristics

From: Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model

Antibody # Immunogen Amino acid position of immunogen in adrenomedullin IgG subtype Kd (M) Maximal inhibition in bioassay (%)
NT-M YRQSMNQGSRSNGCRFGTC 1-19 2a 5.8 × 10-9 24.0
MR-M CTFQKLAHQIYQ 19-31 1 5.9 × 10-9 61.7
CT-M CAPRNKISPQGY-NH2 Cys-40-50 2b 9.0 × 10-9 102.1
NT-H YRQSMNNFQGLRSFGCRFGTC 1-21 1 1.6 × 10-8 25.5
MR-H CTVQKLAHQIYQ 21-32 1 2.0 × 10-9 74.4
CT-H CAPRSKISPQGY-NH2 Cys-42-52 1 1.1 × 10-9 100.7
  1. The antibodies were named according to their epitope specificities as follows: NT, anti-N-terminal region; MR, anti-midregion; CT, anti-C-terminal region; and the suffixes M and H designate mouse and human ADM, respectively.