Skip to main content
Intensive Care Medicine Experimental
Figure 4 | Intensive Care Medicine Experimental

Figure 4

From: Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury

Figure 4

BALF protein. Bronchoalveolar lavage fluid (BALF) concentration of protein from wild-type (WT, white boxes), and Tpl2-deficient mice (Tpl2-/-, gray boxes) subjected only to sample collection (control, n = 7 to 8 per group), mechanical ventilation with normal tidal volume (VT) for 240 min (n = 6 to 8 per group), or high VT for 210 min (n = 7 to 9 per group), and WT mice subjected to 210 min of high VT ventilation treated with a Tpl2 inhibitor, either prior (Tpl2inh pre, n = 5) or after initiation of high VT ventilation (Tpl2inh post, n = 5). BALF proteins' concentration was higher in WT and Tpl2-/-mice subjected to high VT ventilation, than in control WT and Tpl2-/-mice, respectively, *p < 0.001. BALF proteins' concentration was higher in WT mice subjected to high VT ventilation than in similarly ventilated Tpl2-/-mice, and WT mice treated with the Tpl2 inhibitor, #p < 0.01.

Back to article page