Effects of the treatment with a SOD mimetic on lung injury induced by sepsis. The animals were submitted to sepsis or sham-operated, and immediately after surgery, a SOD mimetic was administered once by intra-tracheal instillation. Twenty-four hours after surgery, the content of nitrotyrosine (A), lung permeability (B), interleukin-6 (C), and tumor necrosis factor (D) was determined. The data are expressed as mean ± SD (n = ten animals/group). p value < 0.05 was considered significant when compared to the control.