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Table 1 Principal features of neutrophil respiratory burst studies

From: Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine

Author Study population Subjects ( n) Control population Control ( n) Experimental context Outcome measure correlated with immune readout
Santos [12] Sepsis 49 Healthy volunteer 19 Clinical outcome Yes
Paunel-Gorgulu [19] Trauma 7 Healthy volunteer 6 Experimental No
Bruns [13] Sepsis (cirrhotics) 45 Healthy volunteer and cohort 9 and 39 Pathophysiological No
Shih [20] Trauma 32 Healthy volunteer Not provided Biomarker comparison Yes
Kasten [21] Trauma 3 Healthy volunteer 3 Pathophysiological No
Valente [22] Trauma 24 Healthy volunteer 11 Pathophysiological No
Kawasaki [26] Elective surgery 20 (10,10) Cohort 20 Pathophysiological No
Frohlich [27] Elective surgery 20 Cohort 20 Experimental No
Martins [14] Sepsis 16 Healthy volunteer 16 Pathophysiological Yes
Barth [15] Sepsis 27 Healthy volunteer 11 Biomarker comparison No
Mariano [16] Sepsis (renal replacement therapy) 7 Haemodialysis patients 10 Pathophysiological No
Quaid [23] Trauma 7 Healthy volunteer Not provided Pathophysiological No
Wiezer [28] Elective surgery 22 (6,6,10) Cohort 22 Pathophysiological/experimental Yes
Ahmed [17] Sepsis 32 Healthy volunteer 17 Pathophysiological No
Shih [29] Trauma/surgery 18 Cohort and healthy volunteer 18 Pathophysiological No
Ertel [24] Trauma 10 (5,5) Elective surgery 10 Pathophysiological No
Ogura [25] Trauma 24 (7 infected) Cohort and healthy volunteer 24 and 15 Pathophysiological Yes
Pascual [18] Sepsis 23 Elective surgery 23 Pathophysiological/experimental No
  1. Subjects: values within brackets refer to subgroups within the study.