Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine

Intensive Care Medicine Experimental

Table 1 Principal features of neutrophil respiratory burst studies

Author	Study population	Subjects ( n)	Control population	Control ( n)	Experimental context	Outcome measure correlated with immune readout
Santos [12]	Sepsis	49	Healthy volunteer	19	Clinical outcome	Yes
Paunel-Gorgulu [19]	Trauma	7	Healthy volunteer	6	Experimental	No
Bruns [13]	Sepsis (cirrhotics)	45	Healthy volunteer and cohort	9 and 39	Pathophysiological	No
Shih [20]	Trauma	32	Healthy volunteer	Not provided	Biomarker comparison	Yes
Kasten [21]	Trauma	3	Healthy volunteer	3	Pathophysiological	No
Valente [22]	Trauma	24	Healthy volunteer	11	Pathophysiological	No
Kawasaki [26]	Elective surgery	20 (10,10)	Cohort	20	Pathophysiological	No
Frohlich [27]	Elective surgery	20	Cohort	20	Experimental	No
Martins [14]	Sepsis	16	Healthy volunteer	16	Pathophysiological	Yes
Barth [15]	Sepsis	27	Healthy volunteer	11	Biomarker comparison	No
Mariano [16]	Sepsis (renal replacement therapy)	7	Haemodialysis patients	10	Pathophysiological	No
Quaid [23]	Trauma	7	Healthy volunteer	Not provided	Pathophysiological	No
Wiezer [28]	Elective surgery	22 (6,6,10)	Cohort	22	Pathophysiological/experimental	Yes
Ahmed [17]	Sepsis	32	Healthy volunteer	17	Pathophysiological	No
Shih [29]	Trauma/surgery	18	Cohort and healthy volunteer	18	Pathophysiological	No
Ertel [24]	Trauma	10 (5,5)	Elective surgery	10	Pathophysiological	No
Ogura [25]	Trauma	24 (7 infected)	Cohort and healthy volunteer	24 and 15	Pathophysiological	Yes
Pascual [18]	Sepsis	23	Elective surgery	23	Pathophysiological/experimental	No