Table 2 Principal features of monocyte tolerance studies
Author | Study population | Subjects ( n) | Control population | Controls ( n) | Experimental context | Outcome measure correlated with immune readout |
|---|---|---|---|---|---|---|
Liu [30] | Sepsis | 2 | Healthy volunteer | 2 | Experimental | No |
Buttenschoen [41] | Elective surgery | 20 | Cohort | 20 | Pathophysiological | No |
Pachot [31] | Sepsis | 47 | Healthy volunteer | 21 | Pathophysiological | Yes |
West [32] | Sepsis | 7 | Healthy volunteer, elective surgery and SIRS | 16, 5 and 4 | Pathophysiological | No |
Harter [33] | Sepsis | 21 | Healthy volunteer | 12 | Pathophysiological | No |
Flohe [40] | Surgery in trauma patients | 16 | Healthy volunteer | 12 | Pathophysiological | No |
Escoll [34] | Sepsis | 3 (5) | Healthy volunteer | 3 | Pathophysiological | No |
Heagy [39] | ICU patients (sepsis) | 62 | Healthy volunteer | 15 | Clinical outcome | Yes |
Calvano [35] | Sepsis | 18 (10) | Healthy volunteer | 15 (6) | Pathophysiological | No |
Sfeir [36] | Sepsis | 10 | Healthy volunteer | 10 | Pathophysiological | No |
Kawasaki [42] | Elective surgery | 20 | Cohort | 20 | Pathophysiological | No |
Heagy [37] | Sepsis | 58 | Healthy volunteer | 14 | Clinical outcome | Yes |
Bergmann [38] | Sepsis | 30 (2) | Healthy volunteer | 12 | Pathophysiological | No |