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Table 4 Demographic information of neutrophil respiratory burst studies

From: Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine

Author Age Gender (%male) Subject ethnicity detailed Severity of subject disease Subject drug exposure documentation
Subjects Controls Statistical test result Subjects Controls Statistical test result Index Score No. Groups Sedatives Antibiotics Steroids
Santos [12] 60 ± 17 55.3 ± 18 N 57 53 N N APACHE II 17 (4 to 30) 3 N N N
Gorgulu [19] 46 ± 4 33 ± 2 N* (p < 0.001) 74 59 N N Mortality 9% 1 N N N
Bruns [13] 58 (40 to 80) 45 (37 to 82); 58 (?) 0.437 82 73/48 0.341 N -   1 N N N
Shih [20] 33 ± 14 ? N 66 ? N N ISS 23 2 N N N
Kasten [21] 36 ± 2 38 ± 2 p > 0.05 100 100 p > 0.05 N ISS 23 1 N N N
Valente [22] 75 >65 N 46 ? N N ISS 15.00 1 N N N
Kawasaki [26] 52 ± 4; 54 ± 4 N/A N 70 70 p > 0.05 N ASA I to II 2 Y N N
Frohlich [27] 66 ± 10; 69 ± 6 N/A N 40 20 N N ASA I 2 Y t Y t Y t
Martins [14] 50 ± 21 31 ± 6 N* (p = 0.0011) ? ? N N Mortality 38% 2 N N N
Barth [15] N/S (36 to 82) 24 (22 to 50) N 60 36 N N Mortality 37% 1 N N N
Mariano [16] 67 ± 4 ? N ? ? N N -   1 N N N
Quaid [23] 37 (20 to 71) ? N ? ? N N ISS 24 (17 to 34)   N N N
Wiezer [28] 57 ± 3; 62 ± 2; 58 ± 5 ? N 83, 66, 70   N N APACHE III Graphs (no difference) 3 N N N
Ahmed [17] 55 ± 6 36 ± 16 N* (p < 0.0001) 46 ? N N APACHE II 20 ± 1 1 N N N
Shih [29] 42 ± 19 N/S N 55 ? N N ISS 26 ± 7.2 3 N N N
Ertel [24] N/S ? N ? ? N N AIS Head 4.5 ± 0.2, Chest 4.1 ± 0.1 1 N N N
Ogura [25] 40 ± 19 35 ± 6 N 75 ? N N ISS 31 ± 10 2 N N N
Pascual [18] 59 (27 to 81) 45 (27 to 81) p > 0.05 51 43 N N Mortality 21% 1 N N Y t
  1. Age: N/S, not summarised (tabulated data for every patient provided); question mark (?), not provided within the manuscript; N/A, not applicable. Statistical test result: N, not reported; N*, not reported but we identified the significant p value from the original manuscript data. Severity of subject disease: The average clinical severity score of subjects with an index of spread listed in brackets. The number of severity groups which subjects were divided into is listed. ISS/AIS, Injury Severity Score/Abbreviated Injury Severity Score [87]; ASA, American Society of Anesthesiologists Physical Status Classification System [85]; APACHE II: Acute Physiology and Chronic Health Evaluation II [83], APACHE III, Acute Physiology and Chronic Health Evaluation III [84]. Subject drug use detailed: whether patient exposure to known immunomodulating drugs was documented. A‘t’ signifies that the timing of the drug administration in relation to blood sampling was clear from the study methodology.