Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine

Intensive Care Medicine Experimental

Table 4 Demographic information of neutrophil respiratory burst studies

Author	Age			Gender (%male)			Subject ethnicity detailed	Severity of subject disease			Subject drug exposure documentation
Author	Subjects	Controls	Statistical test result	Subjects	Controls	Statistical test result	Subject ethnicity detailed	Index	Score	No. Groups	Sedatives	Antibiotics	Steroids
Santos [12]	60 ± 17	55.3 ± 18	N	57	53	N	N	APACHE II	17 (4 to 30)	3	N	N	N
Gorgulu [19]	46 ± 4	33 ± 2	N* (p < 0.001)	74	59	N	N	Mortality	9%	1	N	N	N
Bruns [13]	58 (40 to 80)	45 (37 to 82); 58 (?)	0.437	82	73/48	0.341	N	-		1	N	N	N
Shih [20]	33 ± 14	?	N	66	?	N	N	ISS	23	2	N	N	N
Kasten [21]	36 ± 2	38 ± 2	p > 0.05	100	100	p > 0.05	N	ISS	23	1	N	N	N
Valente [22]	75	>65	N	46	?	N	N	ISS	15.00	1	N	N	N
Kawasaki [26]	52 ± 4; 54 ± 4	N/A	N	70	70	p > 0.05	N	ASA	I to II	2	Y	N	N
Frohlich [27]	66 ± 10; 69 ± 6	N/A	N	40	20	N	N	ASA	I	2	Y t	Y t	Y t
Martins [14]	50 ± 21	31 ± 6	N* (p = 0.0011)	?	?	N	N	Mortality	38%	2	N	N	N
Barth [15]	N/S (36 to 82)	24 (22 to 50)	N	60	36	N	N	Mortality	37%	1	N	N	N
Mariano [16]	67 ± 4	?	N	?	?	N	N	-		1	N	N	N
Quaid [23]	37 (20 to 71)	?	N	?	?	N	N	ISS	24 (17 to 34)		N	N	N
Wiezer [28]	57 ± 3; 62 ± 2; 58 ± 5	?	N	83, 66, 70		N	N	APACHE III	Graphs (no difference)	3	N	N	N
Ahmed [17]	55 ± 6	36 ± 16	N* (p < 0.0001)	46	?	N	N	APACHE II	20 ± 1	1	N	N	N
Shih [29]	42 ± 19	N/S	N	55	?	N	N	ISS	26 ± 7.2	3	N	N	N
Ertel [24]	N/S	?	N	?	?	N	N	AIS	Head 4.5 ± 0.2, Chest 4.1 ± 0.1	1	N	N	N
Ogura [25]	40 ± 19	35 ± 6	N	75	?	N	N	ISS	31 ± 10	2	N	N	N
Pascual [18]	59 (27 to 81)	45 (27 to 81)	p > 0.05	51	43	N	N	Mortality	21%	1	N	N	Y t

Age: N/S, not summarised (tabulated data for every patient provided); question mark (?), not provided within the manuscript; N/A, not applicable. Statistical test result: N, not reported; N*, not reported but we identified the significant p value from the original manuscript data. Severity of subject disease: The average clinical severity score of subjects with an index of spread listed in brackets. The number of severity groups which subjects were divided into is listed. ISS/AIS, Injury Severity Score/Abbreviated Injury Severity Score [87]; ASA, American Society of Anesthesiologists Physical Status Classification System [85]; APACHE II: Acute Physiology and Chronic Health Evaluation II [83], APACHE III, Acute Physiology and Chronic Health Evaluation III [84]. Subject drug use detailed: whether patient exposure to known immunomodulating drugs was documented. A‘t’ signifies that the timing of the drug administration in relation to blood sampling was clear from the study methodology.