Figure 4
From: Acute organ injury is associated with alterations in the cell-free plasma transcriptome
Heat maps of differentially expressed genes comparing ischemia-reperfusion to sham operation (group mean data). They visually demonstrate significantly regulated genes upon reperfusion (T = 0). Mouse (A) MI and (B) KI. Significant regulation at T = 0 was defined as p < 0.05 and an absolute fold change ≥ 2. Gene expression is plotted with each gene as a unique horizontal bar and is expressed as log2; therefore, compared to sham, a fold change of 0.5 represents a downregulated expression at an absolute fold change of -2. The gene expression intensity legend is located in the upper right of each panel. Gene expression is followed at 1 and 4 h following reperfusion. In A (MI), there are 589 genes depicted in the heat map, while in B (KI), there are 83 genes which contain easily visualized blocks of regulated genes (both up and down) and identify the respective injuries.