0588. Effects of norepinephrine on tissue perfusion in a sheep model of intraabdominal hypertension
https://doi.org/10.1186/2197-425X-2-S1-P33
© Ferrara et al; licensee Springer. 2014
Published: 26 September 2014
Keywords
Introduction
Intraabdominal hypertension (IAH) produces detrimental effects on tissue perfusion. A putative underlying mechanism is the decrease in abdominal perfusion pressure (APP = mean arterial pressure-intraabdominal pressure). Nevertheless, the benefits of increasing blood pressure on tissue perfusion are controversial.
Objectives
To describe the effects of IAH on regional and microcirculatory intestinal blood flow, renal blood flow, and urine output, as well as their responses to increases in blood pressure induced by norepinephrine.
Methods
Table 1
Period | Group | APP (mm Hg) | Cardiac output (mL.min-1.kg-1) | Mesenteric flow (mL.min-1.kg-1) | ΔPCO2 (mm Hg) | Villi perfused density (mm/mm2) | Renal flow (mL.min-1.kg-1) | Urine output (mL.min.kg-1) |
---|---|---|---|---|---|---|---|---|
Basal | Control | 83±12 | 122±26 | 392±154 | 7±6 | 22±3 | 1906±517 | 1.2±0.3 |
Norepinephrine | 82±7 | 96±17 | 445±318 | 11±7 | 26±3 | 1905±729 | 1.1±0.5 | |
Sham | 76±13 | 113±18 | 405±115 | 4±4 | 23±4 | 1890±639 | 1.4±0.6 | |
1-h IAH | Control | 55±10 | 121±41 | 524±302 | 6±6 | 25±3 | 943±416 | 0.4±0.1 |
Norepinephrine | 53±9 | 118±42 | 633±383 | 12±5 | 27±3 | 552±359 | 0.4±0.7 | |
Sham | 87±14* | 120±28 | 449±88 | 4±6 | 24±3 | 1730±510* | 0.9±0.5* | |
2-h IAH | Control | 49±18* | 134±39 | 522±322 | 8±6 | 24±2 | 869±612 | 0.3±0.4 |
Norepinephrine | 73±10 | 113±39 | 634±310 | 12±6 | 28±3 | 620±439 | 0.2±0.1 | |
Sham | 87±15 | 127±24 | 448±108 | 3±5 | 25±4 | 1678±569* | 1.0±0.6* |
Conclusions
In this experimental model of IAH, the gut and the kidney displayed contrasting responses. While intestinal blood flow and villi microcirculation remained unchanged, renal perfusion and urine output were severely compromised. The increase in blood pressure with norepinephrine failed to improve these variables.
Declarations
Grant acknowledgment
This work was supported by the grant PICT-2010-0495 from Agencia Nacional de Promoción Científica y Tecnológica, Argentina.
Authors’ Affiliations
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.