Volume 2 Supplement 1
0096. Evaluation by videomicroscopy (SDF) of the renal cortex microcirculation and convoluted tubules in acute renal failure during severe sepsis. Experimental study
© Liberatore et al; licensee Springer. 2014
Published: 26 September 2014
The microcirculatory dysfunction as the triggering event of organ dysfunction in sepsis is a universal concept1-3,but the microcirculatory dysfunction and its relationship with the deterioration of adjacent tissue is still unsolved, thus, the macrocirculation parameters guide therapeutic decisions although the impairment of microcirculation precedes the macrocirculation dysfunction.
Investigate the dynamic relationship between microcirculatory injury and adjacent tissue in tubular kidney failure during severe sepsis by SDF.
Wistar rats underwent severe sepsis (iv. E. coli 2x109 CFU, DL70-80 in 26 hours3) and under general anesthesia the dynamics of microcirculatory dysfunction of the renal cortical area was monitored by SDF4 at T0,T30min and T1-T6 hours and the tissue injury by histology (T0,T2h,T6h).
The genesis of acute renal failure in severe sepsis appears to depend on the repetitive cycle of peritubular microcirculatory dysfunction and subsequent tubular injury that exacerbates the progression of the renal injury, thus suggesting the conjoined participation of microvessels and their adjacent cells in the genesis of the solid organ dysfunction.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.