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Volume 3 Supplement 1


  • Poster presentation
  • Open Access

Changing trends of clostridium difficile associated diarrhoea (cdad) in a tertiary care hospital in kolkata, india

  • 1,
  • 2 and
  • 3
Intensive Care Medicine Experimental20153 (Suppl 1) :A118

  • Published:


  • Tertiary Care
  • Stool Sample
  • Secondary Objective
  • Clostridium Difficile
  • Broad Spectrum Antibiotic


In this era of increased and indiscriminate antibiotic usage, it is not only the advent of multi-drug resistant pathogens, but also the rising prevalence of Clostridium difficile Associated Diarrhoea (CDAD) which is drawing concern world-wide. It is important not only to implement a comprehensive antibiotic policy, but also to take up stringent infection control measures to curb the rise of this serious infection.


Primary objective of this study was to know the prevalence and epidemiology of Clostridium difficile infection among the clinically suspected cases of Antibiotic associated diarrhoea in our hospital with a secondary objective of analysis of trend of CDAD over a period of 4 years.


In this retrospective observational study we analyzed the prevalence and epidemiology of CDAD cases among all cases of clinically suspected antibiotic associated diarrhoea occurring in patients admitted in various departments of this hospital over a period of 4 years, since 2011 to 2014. The presence of Clostridium difficile in the stool samples was detected by ELISA for both toxin A and B. All infection control measures taken were recorded.


Out of 287 clinically suspected antibiotic associated diarrhoea cases reported from January 2011 to December 2014, Clostridium difficile toxin was detected in 57 (19.86%) occasions. The prevalence was on a rise after 2011 (10.52%), with a peak of 27% in 2013 and improved gradually over the next year (16.9% in 2014). Prior usage of broad spectrum antibiotics was among the prevalent risk factors identified.


It was important to evaluate the prevalence of CDAD in this part of the country as there is increasing need of awareness among treating physicians on the risk factors and control of such infections. This study demonstrated the significant prevalence of Clostridium difficile Associated Diarrhoea (CDAD) in this hospital. Our study also depicted the importance of judiciously following antibiotic policies and strict infection control measures in a hospital. Furthermore it also raised the interest in future studies for the evaluation of community data on antibiotic usage and Clostridium difficile infection.

Authors’ Affiliations

Infectious Disease, Medica Superspecialty Hospital, Kolkata, India
Critical Care, Medica Superspecialty Hospital, Kolkata, India
Microbiology, Medica Superspecialty Hospital, Kolkata, India


  1. Shashidhar Vishwanath, Arpita Singhal, Annet D'Souza, Chiranjay Mukhopadhyay, Muralidhar Varma, Indira Bairy: Clostridium difficile Infection at a Tertiary Care Hospital in South India, Journal of the association of physicians of india · november 2013 ·. 61 (30):Google Scholar


© Chakraborty et al.; 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.