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Volume 3 Supplement 1


  • Poster presentation
  • Open Access

A comparison of global end-diastolic volume (GEDI) and central venous pressure (CVP) as parameter for volumen assessment in patients during major liver resections

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  • 1,
  • 1,
  • 1,
  • 2,
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  • 3 and
  • 2
Intensive Care Medicine Experimental20153 (Suppl 1) :A216

  • Published:


  • Public Health
  • Intensive Care Unit
  • Medical System
  • Cardiac Index
  • Central Venous Pressure

Goal of Study

The aim of our study was to evaluate the predictive value of CVP with regard GEDI, and correlate these parameters to cardiac Index (CI) and extravascular lung water index (EVLWI).


Prospective study. Surgical intensive care unit, university hospital.

Patients and interventions: 89 hemodynamic measurements using the PiCCO (Pulsion Medical System, Germany) were performed in 18 patients during major liver resection


Mean CVP (8,23 +/- 3,12 mmHg) was normal, whereas mean GEDI (615,2 +/- 135,44 mL/m2) was decreased. Thirty-one CVP measurements were elevated despite simultaneous GEDI levels indicating a normal or decreased preload. Sensitivity, specificity, positive predictive value, and negative predictive value of CVP with regard to volume depletion (GEDI < 650) were 6,28 (0-12,77. CI 95%), 100 (97,86-100, CI 95%, 43, 2 (28,99-50,82, CI 95%) respectively. CVP did not correlate to GEDI (r = -0,065, p = 0,32), CI (r = 0,23, p = 0,176) and EVLWI (extravascular lung water index) (r = -0,05, p= 0,49). GEDI significantly correlated to CI (r = -0,24, p < 0,01) and VVS (r = -0,39, p < 0,01).


Volume depletion according to GEDI was found in more than half the patients. The predictive values of CVP with regard to volume depletion were low GEDI and its changes significantly correlated to CI and its changes, which was not observed for CVP. Therefore, GEDI appears to be more appropriate for volume management during major liver resections with the aim to avoid intraoperative bleeding and transfusion.

Grant Acknowledgment

We express our gratitude to Mutua Madrileña Foundation (Madrid, Spain) for its grant collaboration by without which this work could not have been completed.

Authors’ Affiliations

Facultad Medicina Ciudad Real. Hospital General Universitario Ciudad Real, Ciudad Real, Spain
Hospital de Santa Barbara, Puertollano, Ciudad Real, Spain
Hospital Universitario Ciudad Real, Ciudad Real, Spain


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© Redondo Calvo et al.; 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.