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Volume 3 Supplement 1


  • Poster presentation
  • Open Access

Haematological patients admitted to icu: differences between survivors and non-survivors

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Intensive Care Medicine Experimental20153 (Suppl 1) :A250

  • Published:


  • Independent Risk Factor
  • Respiratory Failure
  • Haematological Malignancy
  • Acute Respiratory Failure
  • Observational Retrospective Study


Patients with haematological malignancies admitted to ICU have high mortality. Reticence of intensive care providers to admit and treat these patients is well described in literature.


To evaluate differences between survivors and non-survivors and provide possible independent risk factors for ICU mortality.


Single centre observational retrospective study in a 14-bed Intensive Care Unit of a University Hospital. All haematological patients admitted between January-2009 and December-2014 were enrolled. Data acquired included: demographics characteristics, haematological diagnosis, reason of ICU admission, severity-of-illness scores (APACHE and SOFA) and intensive care therapy (mechanical ventilation (VM), extrarenal therapy depuration (ETD) and vasopressor support (VS)).


We included 38 patients in the study,15(39,47%) were survivors and 23(60,52%) were non-survivors. Median age of 50,47 ± 13,98 vs 59,78 ± 14,73 (p > 0,05) and predominance of males in both groups (60% vs 73,9%, p > 0,05), respectively. In both groups non-Hodgkin lymphoma was the most frequent haematological malignancy, 53% and 30,4 %, survivors and non-survivors respectively and acute respiratory failure was the most frequent reason for ICU admission(66% and 39,1%, respectively). Intergroup comparisons revealed statistically significant differences in APACHE (19,73 ± 8,05 vs 26,48 ± 8,74, p < 0,05) and SOFA (9 ± 3,4 vs 11,83 ± 3,23, p < 0.05). During the first 24h of ICU admission, 60% of the survivors patients had 2 or more organ failures, and 73,9% in non-survivors group. During evolution in ICU, survivors patients required VM and VS in 80% and 66,7%, respectively. None of them needed EDT. Non-survivors required VM and VS in 91% and 95,7% respectively, and 17,4% needed EDT. There were no statistically significant differences in ICU support therapies between survivors and non-survivors. No independent risk factors for mortality were found by logistic regression analysis.


Mortality in patients with haematological malignancies remains high. There were significant differences in severity-of-illness scores during the first twenty-four hours of ICU admission between survivors and non-survivors. No significant differences in intensive care therapy were found between groups during ICU hospitalization.

Authors’ Affiliations

H Principe de Asturias, Madrid, Spain


  1. Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA: Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of ICNARC Case MIx Programme Database. Crit Care. 2009, 13 (4):Google Scholar
  2. Owczuk R, Wujtewicz MA, Sawicka W, Wadrzyk A, Wujtewicz M: Patients with haematological malignancies requiring invasive mechanical ventilation: differences between survivors and non-survivors in intensive care unit. Support Care Cancer. 2005, 13: 332-338. 10.1007/s00520-004-0750-y.PubMedView ArticleGoogle Scholar


© Lujan Varas et al.; 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.