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Volume 3 Supplement 1

ESICM LIVES 2015

Clinical usefulness of serial neutrophil geletinaseassociated lipocalin (NGAL) change as a predictor for acute kidney injury

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Intr

Plasma neutrophil geletinase-associated lipocalin (NGAL) has been regarded as one of the valuable markers of development of acute kidney injury (AKI) in ICU admitted patients. However, clinical significance of short-term change of plasma NGAL was not clearly investigated.

Methods

50 patients who admitted intensive care unit (ICU) was included by prospective manner. We analyzed plasma NGAL level by Triage immunoassay on ICU admitted time and 12 hours after. Change of estimated glomerular filtration rate (by MDRD equation) and need of renal replacement therapy was investigated. Patients with chronic kidney disease were excluded.

Results

Persistent elevation of plasma NGAL above 1000 ng/mL on 0 and 12 hours was significantly associated with need for early renal replacement therapy. Patient with increased level of NGAL at 12 hours showed unfavorable outcome which is related to renal replacement therapy or progressive renal impairment (13/25; 48% of patients). Conversely, 2/17 (11.8%) of patients had poor renal outcome when NGAL decrease more than 20% from baseline at 12 hours after ICU admission. On multivariate analysis, baseline NGAL and ΔNGAL0-12 hr was independent predictors of unfavorable renal outcome. However, ΔNGAL0-12hr did not significantly correlated with the change of glomerular filtration rate between day 1 and day3.

Conclusions

Our data suggest that measurement of early serum NGAL change may be useful marker in predicting the renal impairment and need for renal replacement therapy in intensive care unit.

Author information

Correspondence to S Park.

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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Yu, H., Park, S., Choe, Y. et al. Clinical usefulness of serial neutrophil geletinaseassociated lipocalin (NGAL) change as a predictor for acute kidney injury. ICMx 3, A260 (2015) doi:10.1186/2197-425X-3-S1-A260

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Keywords

  • Intensive Care Unit
  • Chronic Kidney Disease
  • Glomerular Filtration Rate
  • Renal Impairment
  • Renal Replacement Therapy