- Poster presentation
- Open access
- Published:
The effects of low tidal ventilation on lung strain correlate with pulmonary compliance
Intensive Care Medicine Experimental volume 3, Article number: A310 (2015)
Background
The effect of changing tidal volume on mortality of acute respiratory distress syndrome (ARDS) is determined by pulmonary compliance. We aimed to investigate the effects of different tidal volumes on lung strain in patients with ARDS.
Methods
Nineteen patients were divided into high (Chigh group) and low pulmonary compliance (Clow group) groups based on their pulmonary compliance values (0.6 ml/[cmH2O·kg]). End-expiratory lung volumes (EELV) with different tidal volumes (VT at baseline and at 6, 8, 10 and 12 ml/kg predicted body weight [PBW]) were measured by nitrogen wash-in/washout. Lung strain was calculated as the ratio between tidal volume and EELV.
Results
The mean baseline EELV and pulmonary compliance values were 1873 ml, 0.31 and 0.65 ml/(cmH2O·kg), respectively; all differences were statistically significant between the two groups. For all participants, a positive correlation was found between pulmonary compliance and EELV (r2 = 0.238, p = 0.034). When the tidal volume increased gradually from 6 ml/kg to 12 ml/kg also increased gradually, from 0.31 ± 0.27 to 0.52 ± 0.46, which represented a positive correlation (r2 = 0.956, p < 0.01). In the Chigh group, there were no significant differences in strain between the tidal volume ventilation of 6 ml/kg.PBW and the volumes of 8 and 10 ml/kg.PBW. However, strain increased significantly with the tidal volume of 12 ml/kg.PBW. The mean lung strain was < 0.27 with ventilation at tidal volumes of 6 and 8 ml/kg.PBW, whereas it was > 0.27 with volumes of 10 and 12 ml/kg.PBW. In contrast, in the Clow group, there were no significant differences in strain between the different tidal volumes. However, mean lung strain was ≥ 0.27 for each tidal volume. In addition, 60% of patients' lung strain measured ≥ 0.27 even with tidal volume ventilation of 6 ml/kg.PBW.
Conclusions
Pulmonary compliance affected the effect of tidal volume on strain in ARDS patients, which suggests that setting individual tidal volumes based on pulmonary compliance and strain may be more rational.
Trial Registration
Clinicaltrials.gov identifier NCT01864668
Author information
Authors and Affiliations
Rights and permissions
Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Xie, J., Jin, F., Pan, C. et al. The effects of low tidal ventilation on lung strain correlate with pulmonary compliance. ICMx 3 (Suppl 1), A310 (2015). https://doi.org/10.1186/2197-425X-3-S1-A310
Published:
DOI: https://doi.org/10.1186/2197-425X-3-S1-A310