Patients who did not require (no.:108) vs. those who required VS (no.:31) and patients with invasive (no.:15) vs. those with noninvasive VS (no.:16) were of similar age, gender and GOLD stage (p > 0.2 for all). NT-proBNP was higher in patients who required VS then in those without VS (2407 ± 3431 vs. 1709 ± 4648 ng/L; p < 0.05). Patients with noninvasive VS had higher NT-proBNP then those without VS (3213 ± 4389 vs.1709 ± 4648 ng/L; p < 0.05). The difference between patients treated with noninvasive vs. invasive VS was not significant (3213 ± 4389 vs. 1534 ± 1753 ng/L; p=NS). Patients receiving invasive VS had similar admission NT-proBNP as those without VS (1534 ± 1753 vs. 1709 ± 4648 ng/L; p=NS).