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Volume 3 Supplement 1

ESICM LIVES 2015

  • Poster presentation
  • Open Access

The effect of ulinastatin on sepsis in the rats of adhesion molecules and endothelial function

  • 1,
  • 2 and
  • 2
Intensive Care Medicine Experimental20153 (Suppl 1) :A617

https://doi.org/10.1186/2197-425X-3-S1-A617

  • Published:

Keywords

  • Public Health
  • Endothelial Cell
  • Inflammatory Response
  • Adhesion Molecule
  • Inflammatory Cell

Objectives

To understand the effect of ulinastatin on protecting vascular endothelial cell in sepsis rats and its mechanism.

Methods

Fifty-two rats were: randomly divided into A(ulinastatin group, n = 26), B (NS, normal saline group, n=26 ). 18 h, 3 h before LPS injection, both groups were pretreated with ulinastatin (100,000 U/kg, dissolved in normal saline of 5 ml)and NS (normal saline, 5 ml), respectively. At the time of 1/2 h, 2 h, 4 h, 12 h, 24 h, 72 h, to measure the level of TNF-α, IL-6, IL-10, VCAM and ICAM-1.

Results

Compared with group A, the level of TNF-α and IL-6 were increased significantly in group B (P < 0.05); the level of IL-10 were decreased significantly in group B(P < 0.05). The level of VCAM, ICAM-1 in group A were significantly lower than those in group B (P < 0.05).

Conclusions

Ulinastatin can reduce the mortality of sepsis, its mechanism may be to inhibit the inflammatory response, reduce the release of pro-inflammatory cytokines, promote the expression of anti-inflammatory cytokines and to inhibit the expression of selection, adhesion molecules and angiopoietin receptor, thus it can inhibit the adhesion of inflammatory cells and endothelial cells to improve microvascular permeability and protect the function of endothelial cells.

Authors’ Affiliations

(1)
Zhejiang Chinese Medical University, Hangzhou, China
(2)
Zhejiang Hospital, Hangzhou, China

Copyright

© Hao et al.; 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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