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Volume 3 Supplement 1


  • Poster presentation
  • Open Access

Early failure of noninvasive ventilation in chronic obstructive pulmonary disease with acute hypercapnic respiratory failure

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Intensive Care Medicine Experimental20153 (Suppl 1) :A671

  • Published:


  • Public Health
  • Heart Rate
  • Chronic Obstructive Pulmonary Disease
  • Medical Record
  • Mechanical Ventilation


Noninvasive ventilation (NIV) in the management of chronic obstructive pulmonary disease (COPD) patient with acute hypercapnic respiratory failure is considered a first-line therapy. However, higher mortality was shown in patients receiving transition from NIV to invasive mechanical ventilation than in patients receiving invasive mechanical ventilation from the first management. We tried to find parameters associated with early NIV failure in patients presenting to ED with acute exacerbation of COPD.


Medical records of 218 patients with acute exacerbation of COPD visiting Asan Medical Center and managed with NIV during their stay in the ED from January 2007 to December 2013 were analyzed.


NIV was successful in 191 (87.6%) and 27 (12.4%) failed NIV treatment. Of the variables obtained before NIV treatment, heart rate (≥120/min: OR 2.8, 95% CI 1.1 - 6.8) and pH (7.25 - 7.29: OR 2.6, 95% CI 1.8 - 8.1; < 7.25: OR 15.2, 95% CI 5.0 - 46.1) were significant factors associated with early NIV failure. Of the variables obtained after 1 hr of NIV treatment, heart rate (≥120/min: OR 4.0, 95% CI 1.4 - 11.5) and pH (7.25 - 7.29: OR 4.7, 95% CI 1.5 - 15.1; < 7.25: OR 29.8, 95% CI 15.7 - 62.7) were still significant.


Presence of tachycardia and severe acidosis before NIV treatment, and persistence of tachycardia and severe acidosis after 1hour of NIV treatment predicted early NIV failure.

Authors’ Affiliations

Asan Medical Center, Department of Emergency Medicine, Seoul, Korea, Republic of


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© Cho et al.; 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.