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Intensive Care Medicine Experimental
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Volume 3 Supplement 1

ESICM LIVES 2015

Correlation of hyponatremia, leukocytosis, hypomagnesemia and fever after sah with delayed cerebral ischemia and poor outcome

Intensive Care Medicine Experimental volume 3, Article number: A783 (2015) Cite this article

Introduction

Early identification of patients at an increased risk for delayed cerebral ischemia (DCI) and poor outcome could allow more aggressive therapy and influence better outcome.

Objectives

The aim of this study was to determine a predictive association of hyponatremia, hypomagnesemia, fever and leukocytosis with DCI and poor outcome.

Methods

We prospective enrolled 68 patients with SAH treated from March 2011 to May 2013. Serum levels of sodium, magnesium and leukocyte count were determined at least once a day during the first 10 days after SAH. All patients underwent noncontrast CT scan 9 ± 2 days after SAH. DCI was defined as one or more of the next parameters: a new focal neurological deficit, decline for 2 or more points on the mGCS scale or a new hypodensity on CT scan. The outcome was assessed after 6 months using the eGOS scale.

Results

48% of the patients recruited had delayed cerebral ischemia. Logistic regression model showed significant impact of hyponatremia (p=0,036 OR=4.08 95% CI = 1.09 - 15.26) on DCI and poor outcome (p=0,034 OR=5.11 95% CI = 1.13 - 23.14). We obtained strong corelation of leukocytosis (p = 0.013) with DCI and poor outcome (p=0,016). Association of non infectious fever and hypomagnesemia with DCI existed but wasn´t significant enough.

Conclusions

Our results results confirmed association of hyponatremia and leukocytosis with greater risk of developing DCI and poor clinical outcome.

References

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Author information

Authors and Affiliations

  1. Clinical Centre of Vojvodina, Emergency Centre, Novi Sad, Serbia

    V Vrsajkov, N Mančić & D Glišić

  2. Clinical Centre of Vojvodina, Clinic of Anesthesia and Intensive Therapy, Novi Sad, Serbia

    M Galešev

Authors
  1. V Vrsajkov
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  2. N Mančić
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  3. M Galešev
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  4. D Glišić
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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Cite this article

Vrsajkov, V., Mančić, N., Galešev, M. et al. Correlation of hyponatremia, leukocytosis, hypomagnesemia and fever after sah with delayed cerebral ischemia and poor outcome. ICMx 3 (Suppl 1), A783 (2015). https://doi.org/10.1186/2197-425X-3-S1-A783

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  • DOI: https://doi.org/10.1186/2197-425X-3-S1-A783

Keywords

  • Magnesium
  • Ischemia
  • Logistic Regression
  • Regression Model
  • Serum Level