Skip to main content

Volume 3 Supplement 1


Interleukin-17a as a predictor of occurrence of sepsis in polytrauma patients: a prospective observational study


One of the most serious complications of major trauma is the sequential dysfunction of vital organs, mostly associated with posttraumatic sepsis. IL-17 has been linked to the severity of inflammation in tissues. It initiates the production of other pro-inflammatory mediators resulting in an influx of neutrophils.


To investigate whether the level of IL17A at the day of admission could predict the occurrence of sepsis in polytrauma patients or not.


A prospective cohort study in polytrauma patients. 100 consecutive adult polytrauma patients were included. Serum level of IL-17A was measured at the day of admission to the intensive care unit (ICU). Patients were screened for the development of sepsis. Other data collection included; demographic data Abbreviated Injury Scale (AIS), APACHE II score, acute kidney injury assessed by RIFLE criteria, acute respiratory distress syndrome (ARDS), duration of mechanical ventilation, ICU length of stay & 28-day mortality.


Out of 100 patients 47 (47%) developed sepsis. Serum level of IL-17A was significantly higher in the group of patients who developed sepsis compared to the non-septic group (p-value 0.004). The optimum cut-off value of serum IL-17A for sepsis prediction in polytrauma patients was ≥ 53.8 pg/ml. This cut-off value had a sensitivity of 60.7 % & a specificity of 76.4%, area under the curve (AUC) was 0.687 (95% CI 0.573-0.802), (p value 0.004), as shown in Figure 1. High serum level of IL17-A was associated with increased 28 days ICU mortality as shown in Figure 2 (p value of 0.06).

Neither ARDS nor Multiple Organ Dysfunction Score (MODS) was associated with increased IL-17A serum level.


IL-17A is a potential predictor of sepsis occurrence in patients with polytrauma.


  1. Nakada TA, Russell JA, Boyd JH, et al: IL 17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis. Crit Care. 2011, 15: R254-10.1186/cc10515.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Abdelkader, A., El-Sayed, M., Eladawy, A. et al. Interleukin-17a as a predictor of occurrence of sepsis in polytrauma patients: a prospective observational study. ICMx 3 (Suppl 1), A790 (2015).

Download citation

  • Published:

  • DOI: