Table 1 Patient Characteristics median [range]

Patient No.

72

14

14

16

28

Patient Age

72 [19-88]

75 [22-88]

72.5 [50-82]

72.5 [59-83]

72 [19-88]

Baseline Serum Creatinine (mmol/L)

86 [34-259]

84 [69-112]

94 [58-162]

90 [61-259]

75 [34-221]

Illness Severity Score SOFA/APACHE II

8 [0-16]/ 20 [5-34]

7 [0-11]/ 18 [5-31]

8 [3-16]/ 18 [9-24]

7.5 [4-14]/ 17.5 [13-25]

10 [3-15]/ 20 [13-34]

Reason for admission Medical/Elective surgery/Emergency surgery

46/11/14

7/2/2

10/2/2

8/6/2

21/1/6

BMI

26.42 [17.3-40.4]

25.1 [19.3-39.8]

25.3 [17.3-37.1]

26.4 [20.1-39.3]

28.5 [17.8-40.4]

CYP2D6 Phenotype PM/IM/IMEM/EM/UEM/Unknown

7/24/2/36/1/2

1/6/0/7/0/0

2/3/0/9/0/0

1/5/1/8/1/0

3/10/1/12/0/2

Serum Creatinine at t = 0 (mmol/L)

178 [62-642]

97 [62-126]

156[66-223]

187 [81-280]

281 [74-642]

Time with AKI (h) [KDIGO 0 excluded]

35.5 [6-192]

NA

24 [6-72]

37.5 [6-144]

36 [16-192]