Investigate the relation of procalcitonin and prognosis in severe septic patients in SICU
© Huang et al.; 2015
Published: 1 October 2015
In recent years, procalcitonin(PCT) ,as a new biological marker of systemic bacterial infection, is closely related to the prognosis of sepsis and its role in sepsis is becoming more and more attention.
To investigate the procalcitonin in relations with APCHE II score and prognosis in severe septic patients in SICU.
To Collect 64 cases with severe sepsis hospitalized in SICU of the First Affiliated hospital of Sun Yat-sen University from December 2012 to December 2013, retrospectively. Monitored the dynamic changes of serum PCT,C-reactive protein(CRP), vital signs, blood routine test on the 1st, 3rd and 7th day after admission to SICU, the Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were recorded. Compared the serum PCT, APACHE II, white blood cell(WBC), CRP and other inflammation markers between the two groups. The correlation of PCT and APACHE II was evaluated by spearman correlation analysis. The prediction of mortality of the PCT and APACHE II were evaluated by ROC curves.
There were 33 patients dead and 31 patients survived. The serum PCT level of the patients in the dead group were ((78.49 ± 193.77), (61.55 ± 176.70), (61.68 ± 197.89) ng/ ml) were significantly higher than that in the survived group ((10.70 ± 15.44),(10.60 ± 21.80), (5.67 ± 8.94)ng/ ml) on the 1st, 3th and 7th day(P < 0. 05).The APACHE II score of dead group (21.15 ± 6.93) on 1st day was higher than that of survived group (18.06 ± 5.40) (p < 0.05). There is correlation between PCT and APACHEII .The area under the curve (AUC) was 0.625 (95%CI 0.49-0.76) for PCT, and 0.623 (95%CI 0.49-0.78) for APACHE II.
Severe septic patient's PCT on 1st day is valuable equal to APACHE II score in prognosis assessment.
- Venkataraman R, Kellum JA: Sepsis:update in the management[J]. Adv Chronic Kidney Dis. 2013, 20 (1): 6-13. 10.1053/j.ackd.2012.10.013.PubMedView ArticleGoogle Scholar
- Pieri G, Agarwal B, Burroughs AK: C-reactive protein and bacterial infection in cirrhosis [J]. Ann Gastroenterol. 2014, 27 (2): 113-120.PubMedPubMed CentralGoogle Scholar
- Ciriello V, Gudipati S, Stavrou PZ, et al: Biomarkers predicting sepsis in polytrauma patients : current evidence [J]. Injury. 2013, 44 (12): 1680-1692. 10.1016/j.injury.2013.09.024.PubMedView ArticleGoogle Scholar
- Guclu E, Durmaz Y, Karabay O: Effect of severe sepsis on platelet count and their indices [J]. Afr Health Sci. 2013, 13: 333-338.PubMedPubMed CentralGoogle Scholar
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