- Poster presentation
- Open Access
mean platelet volume as a marker of sepsis in patients admitted to intensive therapy
© Sanchez-Calzada et al.; 2015
- Published: 1 October 2015
- Public Health
- Intensive Care Unit
- Inflammatory Response
- Imaging Study
- Blood Culture
The majority of patients admitted to a intensive care unit has signs of systemic inflammatory response (SIRS) with or without sepsis. Since the dieference betwen morbility and mortality of these two populations is very different is a priority to have markers in order to early differentiate between SIRS with sepsis (S+) and SIRS without sepsis (S-).
To investigate the usefulness of the Mean platelet volume (MPV) for differentiating between S- and S+.
Admitted patients with SIRS signs admitted to two intensive therapies from January 2012 to December 2014 were prospectively evaluated and classifyied in S- and S + according to the results of blood cultures, imaging studies, procalcitonin> 2 ng / mL and the opinion of two certified intensivists outside the study.
A total of 202 cases were included. Gender distribution with 51% (103) females. With a mortality of 12.4% (n = 25). With 50% (n = 101) of the population in the S- group and 50% (n = 101) in the S- group. The only statistically significant differences between the two groups was the SOFA score: S- 8 +/- 2; S + 11 +/- 3 (p < 0.05) and mortality, where all the cases were reported in S +. ROC analysis of MVP was conducted with a cutoff value of < 7.7 fl within day 0 AUC 0.974 (CI 0.955-0.994, p < 0.05), at day 1 AUC 0.970 (0961-0997, p < 0.05), at Day 2 AUC 0.987 (0.971-1.00, p < 0.05),and at Day 3 AUC 0.941 (0903-0978, p < 0.05).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.