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Long-term mortality of patients with sepsis is worse than that of non-septic


Long-term outcomes of septic patients are poorly studied.


Our goal is to determine the rate of mortality and quality of life (QOL) after 2 years of patients with severe sepsis and compare to non-septic patients.


Prospective cohort of 1219 patients of 2 mixed ICU. Patients were followed for 24 months after ICU discharge. We evaluated mortality and quality of life by Karnofsky scale and ADL (Activities Daily Living).


Septic patients (n = 442) had higher mortality rate than non-septic (n = 777) in the ICU (41.6 vs. 13.6%, p < 0.0001), and after two years (74.8 vs. 42.3%, p < 0.0001) - Figure. The QOL of septic patients was lower than the non-septic at ICU admission and after two years. (1) Karnofsky pre-ICU 84 ± 11 vs. 88 ± 16 (p = 0.02), after 2 years: 76 ± 19 vs. 82 ± 17 (p = 0,007); ADL pré-ICU 26 ± 10 vs. 28 ± 7 (p = 0.014), after 2 years 22 ± 11 vs. 25 ± 10 (p = 0.011).


Patients suffering an episode of severe sepsis have increased mortality as compared with non-septic.

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Figure 1


  1. Factors influencing physical functional status in intensive care unit survivors two years after discharge. BMC Anesthesiology. Edited by: Haas et al. 2013, 13: 11-10.1186/1471-2253-13-11.

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Friedman, G., Biason, L. & Teixeira, C. Long-term mortality of patients with sepsis is worse than that of non-septic. ICMx 3 (Suppl 1), A879 (2015).

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