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Correlation between FFP transfusion and actual mortality rate in ICU patients


While plasma donation is still necessary as a unique source of human proteins and to treat coagulation disorders, FFP administration seems to have high rate of inappropriate indication. After all, FFP transfusion is not risk free, and is associated with lung injury, infectious disease and circulatory overload in recipients. On the other hand, patients who die into the ICU have impaired physical status and may have increased demand for FFP transfusion.


The aim of our retrospective observation study was to test the hypothesis that a correlation exists between FFP transfusion and actual mortality rate, in our both medical and surgical ICU served in community hospital.


From January 2006 to June 2014 admitted to our ICU 620 patients, mean age 64.8 years, mean length of ICU stay (LOS) 14.2 days, mean mechanical ventilation duration per ventilated patient (V. Days) 12.23 days, mean APACHE II score on admission 21.2, predicted mortality 38.9 %, actual mortality 31.45 %, Standardized Mortality Ratio (SMR) 0.80. From our database we looked for actual morality rate and the following values and indexes according FFP transfusion per year from 2006 to 2014 (mean values). Total, per patient, per hospitalization days (HD), per patient under mechanical ventilation (pts V) and per ventilation days (VD) Using linear correlation method, we looked for linear slope, correlation coefficient (r), and coefficient of determination (r2), and by linear regression method using ANOVA test we looked for p value, according actual mortality rate and FFP transfusion.


Table 1


According to our data, there was no statistically significant correlation detected between actual mortality rate and FFP transfusion indexes. Our data suggest that even though some patients who die due to multiple organ failure may need more FFP than others, FFP transfused do not correlate statistically significant with actual mortality rate in ICU patients.

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Vakalos, A., Popko, V. Correlation between FFP transfusion and actual mortality rate in ICU patients. ICMx 3 (Suppl 1), A962 (2015).

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