Early and dynamic changes in gene expression in septic shock patients: a genome-wide approach

Intensive Care Medicine Experimental

Table 2 Top biological functions enriched by genomic variations in septic shock patients

Name	pvalue	Number of genes	Percentage in tGDE	Percentage in function
Diseases and disorders
Infectious disease	2.70E−15 to 3.60E−03	1,097	12.3	32.5
Respiratory disease	9.97E−12 to 4.57E−03	194	2.2	5.7
Organismal injury and abnormalities	2.56E−10 to 5.01E−03	316	3.6	8.6
Dermatological diseases and conditions	5.33E−10 to 3.80E−03	295	3.3	9.9
Renal and urological disease	7.73E−10 to 7.73E−10	206	2.3	8.7
Molecular and cellular functions
Cellular development	3.15E−14 to 5.88E−03	933	10.5	15.6
RNA post-transcriptional modification	4.22E−14 to 8.93E−04	196	2.2	45.1
Cell death	3.53E−13 to 6.16E−03	1,880	21.2	30.7
Cellular function and maintenance	8.28E−12 to 5.94E−03	739	8.3	13.4
Cell morphology	1.16E−09 to 4.80E−03	400	4.5	8.9
Physiological system development and function
Hematological system development and function	3.88E−15 to 6.17E−03	1,158	13.0	29.7
Hematopoiesis	3.88E−15 to 4.66E−03	681	7.7	38.4
Lymphoid tissue structure and development	5.06E−11 to 5.10E−03	528	5.9	35.4
Cell-mediated immune response	2.16E−10 to 1.80E−03	305	3.4	33.0
Tissue morphology	2.52E−10 to 4.84E−03	628	7.1	14.0

Results are obtained from the 8,885 common genes differentially expressed between septic shock patients and healthy volunteers over time using false discovery rate <0.05. The ‘p value’ column represents the range of significance for the specific functions included in the high level categories described. The p value is a measure of the likelihood that the association between a set of genes in the dataset and a related function is due to random association. p values <0.05 indicate a statistically significant, non-random association. The p value is calculated by the Fisher’s exact test. The ‘percentage in tGDE’ column represents the percentage of genes found in a function compared to the total number of gene differentially expressed (n = 8,885). The ‘percentage in function’ column represents the percentage of genes found in a function compared to the total number of genes described by IPA to be associated with the function.