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Table 2 Top biological functions enriched by genomic variations in septic shock patients

From: Early and dynamic changes in gene expression in septic shock patients: a genome-wide approach

Name pvalue Number of genes Percentage in tGDE Percentage in function
Diseases and disorders
Infectious disease 2.70E−15 to 3.60E−03 1,097 12.3 32.5
Respiratory disease 9.97E−12 to 4.57E−03 194 2.2 5.7
Organismal injury and abnormalities 2.56E−10 to 5.01E−03 316 3.6 8.6
Dermatological diseases and conditions 5.33E−10 to 3.80E−03 295 3.3 9.9
Renal and urological disease 7.73E−10 to 7.73E−10 206 2.3 8.7
Molecular and cellular functions
Cellular development 3.15E−14 to 5.88E−03 933 10.5 15.6
RNA post-transcriptional modification 4.22E−14 to 8.93E−04 196 2.2 45.1
Cell death 3.53E−13 to 6.16E−03 1,880 21.2 30.7
Cellular function and maintenance 8.28E−12 to 5.94E−03 739 8.3 13.4
Cell morphology 1.16E−09 to 4.80E−03 400 4.5 8.9
Physiological system development and function
Hematological system development and function 3.88E−15 to 6.17E−03 1,158 13.0 29.7
Hematopoiesis 3.88E−15 to 4.66E−03 681 7.7 38.4
Lymphoid tissue structure and development 5.06E−11 to 5.10E−03 528 5.9 35.4
Cell-mediated immune response 2.16E−10 to 1.80E−03 305 3.4 33.0
Tissue morphology 2.52E−10 to 4.84E−03 628 7.1 14.0
  1. Results are obtained from the 8,885 common genes differentially expressed between septic shock patients and healthy volunteers over time using false discovery rate <0.05. The ‘p value’ column represents the range of significance for the specific functions included in the high level categories described. The p value is a measure of the likelihood that the association between a set of genes in the dataset and a related function is due to random association. p values <0.05 indicate a statistically significant, non-random association. The p value is calculated by the Fisher’s exact test. The ‘percentage in tGDE’ column represents the percentage of genes found in a function compared to the total number of gene differentially expressed (n = 8,885). The ‘percentage in function’ column represents the percentage of genes found in a function compared to the total number of genes described by IPA to be associated with the function.