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Intensive Care Medicine Experimental
Figure 1 | Intensive Care Medicine Experimental

Figure 1

From: Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis)

Figure 1

NET-related markers are abundantly present in plasma from patients with melioidosis with or without diabetes. Increased levels of NET-related markers such as nucleosomes and neutrophil elastase are measured in plasma of patients on day of initial presentation with sepsis caused by B. pseudomallei (melioidosis) compared to healthy control subjects. No difference was found between melioidosis patients with or without diabetes (A, D). No difference was seen between melioidosis survivors versus non-survivors (B, E). Straight lines represent the mean, and dashed lines mark the lower limit of detection. Nucleosome levels and neutrophil elastase were measured in all surviving patients on day of enrollment, day 7, and day 28 (follow-up). There is no difference when looking at the normalization of the NET-related makers over time between melioidosis patients with or without diabetes (C, F). Mean and SEM are shown. ***P < 0.001 (unpaired t test).

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