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Intensive Care Medicine Experimental

Table 2 VILI parameters after sRAGE treatment in RAGE KO

From: The receptor for advanced glycation end products in ventilator-induced lung injury

 

Vehicle i.t.

sRAGE i.t.

Cell count [×104]

112 (1.6)

91 (0.9)

Neutrophil influx [×104]

103 (15)

86 (10)

Total protein [μg/ml]

623 (32)

614 (44)

IL-6 [pg/ml]

3162 (291)

1875 (243)**

KC [pg/ml]

8831 (876)

6016 (867)*

MIP-2 [pg/ml]

6115 (688)

2827 (379)***

IL-1β [pg/ml]

676 (69)

850 (122)

TNF-α [pg/ml]

1274 (118)

1425 (141)

  1. Cell count, neutrophil count, total protein, and cytokine and chemokine levels in bronchoalveolar lavage fluid of RAGE knockout (KO) mice with LPS-injured lungs treated with soluble RAGE or vehicle at the start of 5 h of high tidal volume (HVT ~ 15 ml/kg) mechanical ventilation. Data represent mean (SEM) of n = 7 to 8 mice/group. *p < 0.05; **p < 0.01; ***p < 0.001. i.t., intra tracheal.
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