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Table 2 VILI parameters after sRAGE treatment in RAGE KO

From: The receptor for advanced glycation end products in ventilator-induced lung injury

  Vehicle i.t. sRAGE i.t.
Cell count [×104] 112 (1.6) 91 (0.9)
Neutrophil influx [×104] 103 (15) 86 (10)
Total protein [μg/ml] 623 (32) 614 (44)
IL-6 [pg/ml] 3162 (291) 1875 (243)**
KC [pg/ml] 8831 (876) 6016 (867)*
MIP-2 [pg/ml] 6115 (688) 2827 (379)***
IL-1β [pg/ml] 676 (69) 850 (122)
TNF-α [pg/ml] 1274 (118) 1425 (141)
  1. Cell count, neutrophil count, total protein, and cytokine and chemokine levels in bronchoalveolar lavage fluid of RAGE knockout (KO) mice with LPS-injured lungs treated with soluble RAGE or vehicle at the start of 5 h of high tidal volume (HVT ~ 15 ml/kg) mechanical ventilation. Data represent mean (SEM) of n = 7 to 8 mice/group. *p < 0.05; **p < 0.01; ***p < 0.001. i.t., intra tracheal.