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Intensive Care Medicine Experimental
Figure 4 | Intensive Care Medicine Experimental

Figure 4

From: Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism

Figure 4

Endotoxin exposure protects isolated cardiomyocytes from hypoxia-induced cell death. Bar chart depicting cell viability as measured by MTT assay of cardiomyocytes expressed as % of normoxia controls. Groups were normoxia and hypoxia controls and cells pretreated with LPS and inhibitors prior to incubation under conditions of hypoxia (n = 6 per group). The figure demonstrates the protective effect of endotoxin exposure against hypoxia-induced cell death, an effect reversed by exposure to inhibitors of p38 and JNK MAPK and NF-κB inhibition. *Significantly different (p < 0.02, Students t test).

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