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Intensive Care Medicine Experimental
Figure 5 | Intensive Care Medicine Experimental

Figure 5

From: Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase

Figure 5

Neither septic shock nor ROK inhibition reduced arachidonic acid-induced LC 20 phosphorylation. Following stimulation with arachidonic acid, Ser19 phosphorylation of LC20 was significantly increased in platelets from both septic shock (red bar) and non-septic shock control (blue bar) patients. Pre-incubation with Y27632 did not significantly attenuate the arachidonic acid-induced increase in Ser19 phosphorylation of LC20. Arachidonic acid-induced Ser19 phosphorylation of LC20 was not different in platelets derived from patients with septic shock compared to those derived from non-septic shock controls. (n = 14 to 15 per patient group, *p < 0.05).

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