Systolic left ventricular function is preserved during therapeutic hypothermia, also during increases in heart rate with impaired diastolic filling

Intensive Care Medicine Experimental

Table 2 Diastolic variables

	Spontaneous heart rate			Paced heart rate (100)			Paced heart rate (120)			Paced heart rate (140)
Variable	38°C	33°C	p	38°C	33°C	p	38°C	33°C	p	38°C
EDP (mmHg)	10 ± 3	12 ± 2	0.004	10 ± 3	12 ± 3	0.09	10 ± 2	13 ± 4	0.002	12 ± 3
EDV (ml)	79 ± 10	75 ± 11	0.26	77 ± 11	64 ± 9**	0.002	69 ± 8**	57 ± 6**	<0.001	64 ± 8**
EDWth (mm)	10.6 ±1.5	11.1 ± 1.5	0.003	11.0 ± 1.4**	11.9 ± 2.0*	0.02	11.1 ± 1.5**	12.4 ± 2.2**	0.02	11.0 ± 2.0**
Tau (s)	31 ± 6	54 ± 12	<0.001	35 ± 8	61 ± 18	0.001	29 ± 4	53 ± 13	<0.001	29 ± 4
dp/dt_min (mmHg/s)	−1385 ± 529	−742 ± 328	<0.001	−1190 ± 437	−773 ± 257	0.005	−1324 ± 426	−670 ± 332**	<0.001	−1476 ± 555
e' (cm/s)	−2.5 ± 0.9	−1.6 ± 0.7	0.002	−2.3 ± 0.5			−1.9 ± 0.6
DD (ms)	319 ± 79	299 ± 88	0.26	281 ± 11*	199 ± 35**	<0.001	199 ± 14**	142 ± 25**	<0.001	148 ± 23**
DD/CycleD	0.48 ± 0.05	0.38 ± 0.07	<0.001	0.47 ± 0.02	0.33 ± 0.04**	<0.001	0.40 ± 0.03**	0.28 ± 0.05**	<0.001	0.34 ± 0.05**
3.5tau/DD	0.36 ± 0.11	0.72 ± 0.35	0.001	0.44 ± 0.10**	1.10 ± 0.32**	<0.001	0.52 ± 0.09**	1.38 ± 0.49**	<0.001	0.69 ± 0.15**

Values are expressed as mean ± SD. *p ≤ 0.05 for comparison with spontaneous heart rate within temperature level. **p ≤ 0.01 for comparison with spontaneous heart rate within temperature level. EDP, end-diastolic pressure; EDV, end-diastolic volume; EDWth, end-diastolic wall thickness; e′, early wall thinning velocity; DD, diastolic duration; DD/CycleD, diastolic fraction of cardiac cycle duration.