Effects of early hemodynamic resuscitation on left ventricular performance and microcirculatory function during endotoxic shock

Intensive Care Medicine Experimental

Table 1 Systemic hemodynamics and metabolic data

Variables	Time	LPS group ( n = 9)	ERP group ( n = 8)	SHAM group ( n = 8)
MAP (mm Hg)	T0	92.3 ± 20.1	85.7 ± 22.1	86.4 ± 18.1
MAP (mm Hg)	T180	38.1 ± 16.2 *	57.8 ± 10.8 * §	84.2 ± 12 §
CVP (mm Hg)	T0	7.1 ± 3.5	4.8 ± 2.8	5.1 ± 2.1
CVP (mm Hg)	T180	6.5 ± 2.9	7.1 ± 2.3	7 ± 2.1
PAOP (mm Hg)	T0	5.6 ± 2.7	5.3 ± 2.4	5.5 ± 4.5
PAOP (mm Hg)	T180	6.4 ± 2.7	6.9 ± 3.4	6.5 ± 4
HR (bpm)	T0	97 ± 18	100 ± 24	98 ± 19
HR (bpm)	T180	106 ± 40	157 ± 21 * §	95 ± 25
CI (mL/min/kg)	T0	87.6 ± 29.6	69.4 ± 20.5	65.3 ± 16.7
CI (mL/min/kg)	T180	45 ± 22.6 *	95.8 ± 36.6 * ‡	65.1 ± 25.2
SVRI (dyn.s/cm⁵)/kg	T0	163.9 ± 96.2	166 ± 57	209.3 ± 91
SVRI (dyn.s/cm⁵)/kg	T180	108.1 ± 63.4 *	76.2 ± 22.6 *	201.8 ± 71.4 §
IDO₂ (mL/min/kg)	T0	13.4 ± 5.4	11 ± 2.8	9.1 ± 4.7
IDO₂ (mL/min/kg)	T180	6.4 ± 3.6 *	13.3 ± 4.2 * ‡	10 ± 4
IVO₂ (mL/min/kg)	T0	6.2 ± 1.8	6.4 ± 1.3	5.7 ± 2.8
IVO₂ (mL/min/kg)	T180	3.8 ± 1.5 *	5.9 ± 2.2	5.3 ± 2.1
ERO₂ (%)	T0	54.5 ± 10.2	58.6 ± 5.7	52.4 ± 13.4
ERO₂ (%)	T180	65.2 ± 13.5 *	44.5 ± 8.8 * ‡	54 ± 6
Lactate (mmoL/L)	T0	1.3 ± 0.4	1.4 ± 0.6	1.4 ± 0.6
Lactate (mmoL/L)	T180	5.1 ± 2.4 *	4.1 ± 2.7 *	1.1 ± 0.3 §
SvO₂ (%)	T0	48.8 ± 8.4	41.7 ± 7.1	49 ± 13.2
SvO₂ (%)	T180	34 ± 14.4 *	55.4 ± 9.3 * ‡	46.6 ± 8.7

Values are mean ± SD. LPS, E. coli lipopolysaccharide; ERP, early resuscitation protocol; MAP, mean arterial pressure; CVP, central venous pressure; PAOP, pulmonary artery occlusion pressure; HR, heart rate; CI, cardiac index; SVRI, systemic vascular resistance index; IDO₂, systemic oxygen delivery index; IVO₂, systemic oxygen consumption index; ERO₂, systemic oxygen extraction ratio; Lactate, arterial lactate; SvO₂, mixed venous oxygen saturation. * p < .05 compared to baseline values; ‡p < .05 compared to LPS; §p < .05 compared to other groups.