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Fig. 7 | Intensive Care Medicine Experimental

Fig. 7

From: Noradrenalin effectively rescues mice from blast lung injury caused by laser-induced shock waves

Fig. 7

Effect of the drugs administered to the mice immediately after two exposures to 1.4 J/cm2 LISWs on cardiac output (CO), left ventricular ejection fraction (EF), and systemic vascular resistance (SVR). a CO was determined before (baseline) and at 1 min after LISW. NA, DOB, and NS groups were exposed twice to LISW and then received 20 μg of noradrenaline, 60 μg of dobutamine, and 0.1 mL of normal saline, respectively. ##p < 0.01 vs. corresponding baseline values in NA (Wilcoxon signed-rank test). †p < 0.05 vs. corresponding baseline values in NS groups (paired t test). The data are shown as the mean ± standard error. b EF was determined before (baseline) and at 1 min after LISW. NA, DOB, and NS groups were exposed twice to LISW and then received 20 μg of noradrenaline, 60 μg of dobutamine, and 0.1 mL of normal saline, respectively. #p < 0.05 vs. corresponding baseline values in NA or NS groups (Wilcoxon signed-rank test). The data are shown as the mean ± standard error. c SVR was determined before (baseline) and at 1 min after LISW. NA, DOB, and NS groups were exposed twice to LISW and then received 20 μg of noradrenaline, 60 μg of dobutamine, and 0.1 mL of normal saline, respectively. #p < 0.05 vs. baseline value in NA group (Wilcoxon signed-rank test). The data are shown as the mean ± standard error

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