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Table 2 Pulmonary data in low tidal volume (LVt) versus airway pressure release ventilation (APRV)

From: The effects of airway pressure release ventilation on respiratory mechanics in extrapulmonary lung injury

   Baseline 12 h 24 h 36 h 48 h p value
Plateau pressure (cmH2O) LVt 16.7 ± 2.7 14.5 ± 0.5 18.2 ± 1.1 22.0 ± 1.9 22.2 ± 2.0 0.0188§
APRV 18.2 ± 2.2 22.8 ± 2.5* 27.0 ± 0.6* 31.0 ± 0.6* 34.3 ± 0.9*
Transpulmonary pressure (cmH2O) LVt 12.7 ± 3.8 9.6 ± 1.7 11.2 ± 0.1 13.8 ± 1.7 14.9 ± 1.9 0.1116
APRV 12.7 ± 3.2 12.6 ± 1.3 16.4 ± 1.5 14.6 ± 2.1 17.3 ± 2.9
Pleural pressure (cmH2O) LVt 3.9 ± 1.3 4.9 ± 1.4 6.9 ± 1.1 8.2 ± 0.3 7.6 ± 0.5 <0.0001§
APRV 5.5 ± 1.0 10.2 ± 1.2* 10.6 ± 1.2 16.1 ± 1.4* 17.4 ± 3.5*
End-expiratory pressure (set) (cmH2O) LVt 5.0 ± 0.0 5.0 ± 0.0 5.0 ± 0.0 6.0 ± 1.0 6.6 ± 1.7 <0.0001§
APRV 0.0 ± 0.0* 0.0 ± 0.0* 0.0 ± 0.0* 0.0 ± 0.0* 0.0 ± 0.0*
End-expiratory pressure (measured) (cmH2O) LVt 5.1 ± 0.1 5.0 ± 0.1 5.2 ± 0.1 6.2 ± 1.2 6.6 ± 1.7 <0.0001§
APRV 5.1 ± 0.1 10.7 ± 0.9* 11.8 ± 0.6* 14.2 ± 1.1* 17.8 ± 2.0*
Tidal volume (cc kg−1) LVt 10.2 ± 0.1 6.0 ± 0.0 6.0 ± 0.0 5.9 ± 0.0 5.6 ± 0.3 <0.0001§
APRV 10.0 ± 0.1 9.7 ± 0.3* 11.0 ± 0.8* 12.3 ± 0.6* 13.3 0.6*
Respiratory system elastance (cmH2O L−1) LVt 31.2 ± 7.9 43.5 ± 4.2 59.8 ± 6.3 72.8 ± 8.3 76.4 ± 9.4 <0.0001§
APRV 35.8 ± 6.0 34.2 ± 4.8 38.5 ± 5.5 38.0 ± 5.6* 33.4 ± 4.6*
Lung elastance (cmH2O L−1) LVt 24.4 ± 9.4 29.3 ± 6.7 36.7 ± 1.6 45.7 ± 6.3 50.3 ± 8.3 <0.0001§
APRV 29.7 ± 6.6 18.8 ± 2.6 23.8 ± 5.1 18.8 ± 4.8* 17.6 ± 5.1*
Chest wall elastance (cmH2O L−1) LVt 6.8 ± 1.9 14.2 ± 3.9 23.1 ± 4.8 27.0 ± 2.6 26.2 ± 2.9 0.0377§
APRV 10.6 ± 1.8 15.4 ± 2.3 14.7 ± 1.0 19.2 ± 1.1* 15.8 ± 0.5*
FiO2 (%) LVt 1.00 ± 0.00 0.24 ± 0.03 0.27 ± 0.05 0.33 ± 0.03 0.37 ± 0.07 <0.0001§
APRV 1.00 ± 0.00 0.21 ± 0.00 0.21 ± 0.00 0.21 ± 0.00* 0.21 ± 0.00
PaO2/FiO2 (mmHg) LVt 550.4 ± 20.1 429.4 ± 36.6 411.3 ± 39.2 269.6 ± 6.4 226.2 ± 17.1 <0.0001§
APRV 556.8 ± 27.4 443.5 ± 29.4 416.8 ± 26.5 374.6 ± 13.8* 465.7 ± 66.5*
  1. The end-expiratory pressure set on the ventilator with LVt (PEEP) and APRV (P Low) are distinguished from the actual end-expiratory pressure measured at the level of the trachea. p value (right column) following RM ANOVA with § p < 0.05 considered significant. *p < 0.05 LVt versus APRV following post hoc analysis with Tukey’s test