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Intensive Care Medicine Experimental
Fig. 3 | Intensive Care Medicine Experimental

Fig. 3

From: Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality

Fig. 3

Comparisons between survivors and non-survivors in the sepsis and SIRS subcohorts, regarding a severity of illness, b hormonal, c glucocorticoid receptor, d extracellular and e intracellular innate immune, and f inflammatory acute stress response. The p value was calculated using the Mann-Whitney U test and a p value <0.05 (two sided) was considered statistically significant. Sepsis and/or mortality was associated with or had a trend for increased severity of illness, expression of extracellular HSP90α and HSP72, cytokines, cortisol, and GR and a trend for lower intracellular HSP72. Asterisk indicates p < 0.05 between non-survivors and survivors in each diagnostic group; number sign indicates p < 0.05 between sepsis and SIRS in each outcome group. SIRS systemic inflammatory response syndrome, APACHE II Acute Physiology and Chronic Evaluation, SOFA Sequential Organ Failure Assessment, SAPS III Simplified Acute Physiology Score III, GR glucocorticoid receptor, HSP heat shock protein, IL interleukin, IFN-γ interferon gamma, MFI mean fluorescence intensity

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