Table 1 Laboratory parameters on day 0 (baseline—before operation) and on day 3 before endotoxin administration

Weight (kg)

60.0 (57.8–60.9)

58.0 (57.0–60.6)

60.0 (53.8–60.3)

57.0 (56.3–59.7)

Weight loss (kg)

n.a.

n.a.

2.5 (0.6–3.0)

1.0 (0.9–1.0)

Creatinine (mg/dl)

1.1 (1.1–1.4)

1.5 (1.4–1.6)

1.6 (1.4–1.6)*

1.6 (1.6–1.8)

Urea (mg/dl)

13.0 (10.0–17.0)

12.0 (10.0–12.0)

14.0 (13.0–15.0)

11.0 (7.0–11.0)

Alkaline phosphatase (U/l)

130 (122–151)

154 (152–160)

239 (208–262)*

261 (222–264)*

Total bilirubin (mg/dl)

0.1 (0.1–0.2)

0.2 (0.2–0.2)

5.3 (4.5–5.7)*

4.7 (4.2–5.9)*

GPT (U/l)

34 (28–39)

32 (30–38)

53 (38–59)*

47 (39–48)*

GOT (U/l)

27 (20–31)

31 (28–33)

106 (79–111)*

62 (54–64)*

LDH (U/l)

491 (405–514)

507 (459–535)

779 (757–855)*

629 (608–679)*

Total protein (g/dl)

5.3 (5.2–5.5)

5.8 (5.6–5.8)

5.9 (5.5–6.0)

5.7 (5.6–5.7)

Total calcium (mg/dl)

2.45 (2.38–2.51)

2.49 (2.47–2.51)

2.51 (2.50–2.56)

2.64 (2.57–2.69)

Phosphate (mg/dl)

9.5 (9.0–10–0)

9.0 (8.9–9.2)

8.4 (8.0–8.9)

7.7 (7.5–8.4)

Magnesium (mmol/l)

0.91 (0.85–0.92)

0.88 (0.85–0.89)

0.89 (0.86–0.95)

0.84 (0.81–0.89)

Lactate (mmol/l)

1.3 (1.2–2.3)

2.9 (1.3–2.9)

1.6 (1.5–2.2)

1.4 (1.2–1.6)

Ammonia (μg/dl)

42.0 (39–52)

53.0 (47.0–54.0)

389 (278–403)*

182 (165–210)*

Osmolality (mosmol/kg)

291 (290–291)

288 (288–290)

294 (291–296)*

292 (291–294)*

Albumin (electrophoresis) (g/dl)

2.9 (2.8–2.9)

3.1 (2.9–3.1)

2.8 (2.7–2.9)

2.7 (2.6–3.0)

Quick value (%)

114 (111–119)

106 (105–111)

95 (89–110)*

86.0 (82–96)*

INR

0.9 (0.9–0.9)

0.9 (0.9–1.0)

1.0 (0.9–1.1)*

1.1 (1.0–1.1)*

Fibrinogen (mg/dl)

400 (377–412)

418 (404–434)

665 (629–813)*

716 (710–794)*

Leukocytes (10³/μl)

15.2 (14.2–15.9)

15.4 (12.8–16.5)

17.8 (17.7–19.0)*

21.9 (21.4–23.2)*

Hemoglobin (g/dl)

10.0 (9.4–10.1)

10.5 (10.4–11.0)

10.5 (10.5–11.4)

10.2 (10.0–11.3)

Hematocrit (%)

32.8 (32.7–33.0)

34.4 (34.3–37.2)

36.7 (34.6–38.0)

33.7 (33.3–38.1)

Platelets (10³/μl)

399 (335–407)

332 (318–402)

393 (359–437)

383 (378–398)