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Table 1 Septic shock patients’ characteristics (n = 7)

From: Intra-cellular lactate concentration in T lymphocytes from septic shock patients — a pilot study

Age 73 [65–77] Documentation of infection
Male sex 4 (57%)  Clinics only 0 (0%)
Day 28 mortality 3 (43%)  Clinics + imaging 1 (14%)
    Clinics + surgery 1 (14%)
SAPS II score 62 [56–65]   
SOFA score 9 [8–12] Microbiologically proved 5 (71%)
Charlson score 1 [0–3.5]  Gram-negative 4 (80%)
    Gram-positive 1 (20%)
Norepinephrine dosage
At day 1 (μg/kg/min) 0.83 [0.54–1.78] Lactatemia
    Day 1 2.8 [2.3–3.8]
Mechanical ventilation 7 (100%)  Day 3 1.6 [1.4–1.6]
Type of admission Lymphocyte purity 76.5 [69.2–85.9]
 Medical 2 (29%) CD3 purity 97.3 [96.6–97.9]
 Surgical 5 (71%)   
   CD4 (%) 72.0 [59.9–80.9]
Type of infection CD8 (%) 14.8 [11.0–26.5]
 Community-acquired 2 29%) CD4−/8− (%) 3.1 [1.8–8.2]
 Nosocomial 5 (71%)   
   CD4 (/μL) 295 [220–413]
Site of infection Treg (%) 7.7 [7.3–9.5]
 Pulmonary 2 (29%)   
 Intra-abdominal 3 (43%) mHLA-DR (ab/c) 3079 [2590–4010]
 Urinary 1 (14%)   
 Others 1 (14%)   
  1. SAPS II Simplified Acute Physiological Score II, SOFA sepsis-related organ failure assessment, Treg CD4 + CD25highCD127low regulatory T lymphocytes score, mHLA-DR monocyte surface expression of HLA-DR, ab/c number of antibodies bound per cell. Normal value for mHLA-DR is > 15,000 ab/c, indicative of immunocompetence (Docke, 2005). In-lab normal values for CD4+ T cells absolute count are 336–1126 cells/μL and 4–10% of total CD4+ lymphocytes for Treg. Values are expressed as number (percentage) for categorical variables and median [Q1–Q3] for continuous variables