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Intensive Care Medicine Experimental

Table 4 Comparative epithelial lining fluid concentrations for nebulised and tobramycin sheep at two time points, 1 and 6 h post-antibiotic administration

From: A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models

ELF time points

Nebulised tobramycin

Intravenous tobramycin

1 h (mg/l)

1.94

0.19

6 h (mg/l)

0.07

0.38

AUCELF (mg-h/l)

5.99

1.52

AUCplasma (mg-h/l)

56.88

53.60

AUClung/AUCplasma (mg-h/l)

0.11

0.03

  1. ELF epithelial lining fluid; AUC area under the concentration-time curve
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