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Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome

Fig. 1

Schematic representation of study procedures for gene prioritization for case-control association studies with ARDS susceptibility. Total RNA from left lung tissue from surviving animals of a rodent model of ARDS was used to perform gene expression comparisons among three experimental groups on different mechanical ventilation (MV) strategies. These analyses revealed neuron projection morphogenesis and signaling by vascular endothelial growth factor (VEGF) as differentially deregulated pathways, as well as in independent human genomic data. Among the genes contained in both pathways (9 and 44 genes, respectively), only those with at least one significant SNP (p value ≤ 0.01) in the GWAS of ARDS were prioritized: dynein cytoplasmatic 2, heavy chain 1 (DYNC2H1), fms-related tyrosine kinase-1 (FLT1), integrin, alpha-1 (ITGA1), and peroxiredoxin-6 (PRDX6), the latter was excluded for association analyses because the top SNP was monomorphic in the discovery study

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