Table 3 Modified MGS scoring system for monitoring of surrogate endpoints and assessment of disease severity in mouse CLP sepsis, adapted from Langford et al. [6]
Mouse Grimace Scale (MGS) | ||||
|---|---|---|---|---|
Score | 0 | 1 | 2 | 3 |
Orbital tightening | Eyes open | Eyes slightly closed | Eyes half closed | Eyes closed |
Nose and cheek bulge | Normal, flat | Slightly rounded extension of skin around nose bridge | Wrinkled nose or cheeks, slight bulge in cheeks | Obvious, rigid appearing nose and cheek bulge |
Ear positioning | Ears flat, back against body | Ears alert, slightly angled from back | Ears partially positioned forward or apart | Ears completely erect, far apart |
Whisker change | Normal | Some whiskers erect | Whiskers mostly erect or clumping | All whiskers standing on end |