A new way of monitoring mechanical ventilation by measurement of particle flow from the airways using Pexa method in vivo and during ex vivo lung perfusion in DCD lung transplantation

Intensive Care Medicine Experimental

Table 2 Shows total particle count for the different particle sizes from 1 to 8 during ex vivo ventilation.

	Ex vivo lung perfusion
	VCV versus PVC			Small tidal volumes versus large tidal volumes		Low PEEP versus high PEEP
	VCV¹	PCV¹	p value	VCV²	p value	PCV²	PCV³	p value
Particle 1	141,087 ± 36,170	51,135 ± 31,907	0.020*	224,313 ± 94,259	0.018*	177,117 ± 41,998	23,258 ± 5060	0.020*
Particle 2	150,750 ± 208	57,818 ± 33,823	0.022*	239,288 ± 95,435	0.026*	222,225 ± 56,596	23,913 ± 5575	0.025*
Particle 3	192,577 ± 46,145	76,725 ± 41,409	0.014*	316,550 ± 120,963	0.028*	308,437 ± 80,941	34,092 ± 8124	0.027*
Particle 4	106,700 ± 35,066	43,818 ± 21,247	0.021*	168,932 ± 63,215	0.028*	186,240 ± 49,551	19,900 ± 4730	0.029*
Particle 5	35,373 ± 12,136	14,056 ± 6778	0.020*	54,517 ± 21,202	0.034*	60,478 ± 19,729	8052 ± 2514	0.032*
Particle 6	23,542 ± 8709	7657 ± 3532	0.034*	33,600 ± 12,443	0.048*	35,550 ± 12,188	5486 ± 1543	0.038*
Particle 7	7070 ± 2883	2388 ± 1097	n.s.	10,107 ± 3723	n.s.	8497 ± 2997	2018 ± 538	0.536
Particle 8	3340 ± 1282	722 ± 222	n.s.	3757 ± 1354	n.s.	3000 ± 977	790 ± 262	0.045*

VCV1 volume-controlled ventilation with small tidal volumes and PEEP at 2, VCV2 volume-controlled ventilation with large tidal volumes and PEEP at 2, PCV1 pressure-controlled ventilation with small tidal volumes and PEEP at 2, PCV2 pressure controlled ventilation with large tidal volumes and PEEP at 2, PCV3 pressure-controlled ventilation with big tidal volumes and PEEP at 10
Significance was defined as: p < 0.05 (*), and p > 0.05 (not significant, n.s.)