Table 2 (abstract P21). Fluid and vasopressor use. Values are median (interquartile range) unless otherwise stated. T0 -randomisation; T6 – 6 hours post-randomisation; T24 – 24h post-randomisation

 Pre-randomisation

1250 (1000, 2000)

1450 (1000, 1500)

0.69

 T0-T6 (ml)

1655 (1017, 2500)

938 (592, 1458)

<0.001

 T0-T6/kg (ml)

23 (15, 33)

12 (7, 20)

<0.001

 Total prerandomisation-T6

3000 (2550, 3900)

2387 (1860, 2750)

<0.001

 Total to T6/kg (ml)

43 (35, 49)

30 (23, 39)

<0.001

 T6-T24 (ml)

1000 (428, 1743)

1134 (500, 2000)

0.73

 Total prerand-T24 (ml)

4250 (3500, 5207)

3543 (2812, 4410)

0.005

 Total to T24/kg (ml)

61 (46, 79)

40 (33, 64)

0.005

Vasopressor use N (%)

26 (53)

39 (78)

 Vasopressor in ED N (%)

23 (47)

36 (72)

0.011

 Vasopressor at 24h N (%)

19 (39)

24 (48)

0.35

 Time to vasopressor commencement from T0 (h)

2 (1, 3)

1 (1, 1)

0.001

   Noradrenaline N (%)

23 (47)

30 (60)

0.33

   Metaraminol only N (%)

3 (2)

9 (18)

   Central venous access N (%)

20 (41)

26 (52)

0.42

   Volume prior to vasopressor commencement (ml)

2000 (2000, 2777)

1400 (1000, 1700)

<0.001

   Duration of vasopressor (h)

33 (15, 50)

21 (9, 42)

0.13

   Peak vasopressor dose (noradrenaline equivalent) (mcg/kg/min)

0.18 (0.1, 0.43)

0.11 (0.08, 0.22)

0.14

   Mean arterial pressure T0-T6 (mmHg)

72±6

73±6

0.31